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Main Profile

Full Name and Degrees: 
Tea Soon Park, Ph.D.
Member Role: 
Post-Doctoral Fellow/Trainee
Institutional affiliation: 
The Johns Hopkins School of Medicine

Tea Soon obtained her Ph.D. in Bioengineering at University of Pittsburgh in 2008. Her thesis title was “Development of hematopoietic, endothelial, and perivascular cells from human embryonic and fetal stem cells” under supervision of Dr. Bruno Peault. After her graduation, she joined as a post-doctoral fellow in Dr. Elias Zambidis laboratory at the Institution for Cell Engineering and Dept. of Pediatric Oncology, Johns Hopkins School of Medicine. Tea Soon is working on 1) Generation of blood progenitor cell-derived induced pluripotent stem cells using episomal plasmid system, 2) Development of hematopoietic and vascular lineage progenitors from human pluripotent stem cells, and 3) Regenerative potential of vascular progenitor cells in the ischemic ocular vascular disease (retinopathy) mouse model. 

Additional links: 
Hub Site: 
03-Alan Friedman
research focus: 

iPSC Hematologic and Vascular Therapies

Recent publications: 
1. Zimmerlin L, Park TS, Donnenberg VS, Zambidis ET, and Donnenberg AD, Book chapter: Pericytes: a ubiquitous source of multipotent adult tissue stem cells, Melvin Shiffman (Editor), Stem Cells in Aesthetic Procedures, Springer, in press 2. Jalil, R.A., Huang, N.F., Kim J., Herold, J., Volz, K., Park, T.S., Lee, J.C., Zambidis, E., Reijo-Pera, R., Cooke, J.P., Human Induced Pluripotent Stem Cell-Derived Endothelial Cells Exhibit Functional Heterogeneity, American Journal of Translational Research, in press 3. Panicker LM, Miller M, Park TS, Patel B. Azevedo JL, Awad O, Masood AM, Veenstra TM, Goldin E, Polumuri SK, Vogel SN, Sidransky E, Zambidis ET, and Feldman RA, Modeling Gaucher disease using human induced pluripotent stem (iPS) cells, PNAS, 2012 Oct 30;109(44):18054-9. doi: 10.1073/pnas.1207889109 4. Park TS, Huo JS, Peters A, Talbot CC Jr, Verma K, Zimmerlin L, Kaplan IM, Zambidis ET., Growth Factor-Activated Stem Cell Circuits and Stromal Signals Cooperatively Accelerate Non-Integrated iPSC Reprogramming of Human Myeloid Progenitors. PLoS One. 2012;7(8):e42838. doi: 10.1371/journal.pone.0042838. 5. Park TS, Zimmerlin L, Zambidis ET, Efficient and Simultaneous Generation of Hematopoietic and Vascular Progenitors from Human Induced Pluripotent Stem Cells, Cytometry Part A, 2012 Jun 26. doi: 10.1002/cyto.a.22090. 6. Park TS, Burridge PW, and Zambidis ET, Book chapter: Generation of Multipotent CD34+CD45+ Hematopoietic Progenitors from Human Induced Pluripotent Stem Cells, Kaiming Ye and Sha Jin (editors), Human Embryonic and Induced Pluripotent Stem Cells: Lineage-Specific Differentiation Protocols, Springer Protocols Handbooks, DOI 10.1007/978-1-61779-267-0_24, 2011 7. Park TS, Gavina M, Chen CW, Sun B, Teng PN, Huard J, Deasy BM, Zimmerlin L, and Péault B. Placental Perivascular Cells for Human Muscle Regeneration. Stem Cells Dev. 2011 Mar;20(3):451-63. 8. Peters, A., Burridge, P., Levine, M., Pryzhkova, M., Park, T.S., Yuan, X., and Zambidis, E. Challenges in generating therapeutic patient-specific hemangioblasts and hematopoietic stem cells from human pluripotent stem cells, Int. J. Development Biology, 2010;54(6-7):965-90. 9. Park, TS, Zambidis, ET, A role of the renin-angiotensin system in hematopoiesis, Hematologica, 2009 Jun;94(6):745-7. 10. Park TS, Zambidis ET, Lucitti JL, Logar A, Keller BB, and Peault B, Human embryonic stem cell-derived hemato-endothelial progenitors engraft chicken embryos, Experimental Hematology, 2009 Jan;37(1):31-41. 11. Crisan M, Yap S, Casteilla L, Chen CW, Corselli M, Park TS, Sun B, Zheng B, Zhang L, Norotte C, Teng PN, Traas J, Schugar R, Deasy BM, Andriolo G, Badylak S, Buhring HJ, Lazzari L, Giacobino JP, Huard J, and Peault B, A perivascular origin for mesenchymal stem cells in multiple human organs, Cell Stem Cells, 2008 Sep 11;3(3):301-13. 12. Zambidis ET, Park TS, Yu Wayne, Tam A, Levine M, Yuan X, Pryzhkova M, and Peault B, Expression of ACE (CD143) identifies and regulates primitive hemangioblasts derived from human pluripotent stem cells, Blood, 2008 Nov 1;112(9):3601-14. 13. Zambidis ET, Sinka L, Tavian M, Jokubaitis V, Park TS, Simmons PJ, Péault B, Emergence of human angio-hematopoietic cells in normal development and from cultured embryonic stem cells, Annals of New York Academy Sciences, 2007 Jun;1106:223-32 14. Zambidis ET, Péault B, Park TS, Bunz F, Civin CL, Hematopoietic differentiation of human embryonic stem cells progresses through sequential hematoendothelial, primitive, and definitive stages resembling human yolk sac development. Blood, 2005 Aug 1;106(3):860-70
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