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Main Profile

Full Name and Degrees: 
Sean Wu, M.D., Ph.D.
Member Role: 
Institutional affiliation: 
Stanford University School of Medicine

Dr. Sean Wu joins the Consortium from Massachusetts General Hospital where he is an investigator at the Cardiovascular Research Center and a staff cardiologist.

He received his bachelor’s degree in biological sciences and mechanical engineering from Stanford University. He then went on to earn both his M.D. and his Ph.D. as part of the NIH-funded Medical Scientist Training Program at Duke University School of Medicine (1999).

Dr. Wu has received many awards and honors including:

  • Fellow, American College of Cardiology (2010)
  • NIH Director's New Innovator Award (2008)
  • GlaxoSmithKline Young Investigator Competitive Award in Cardiovascular Medicine (2007)
  • Mentored Clinical Scientist Development Award, National Heart Lung and Blood Institute (2005)
  • Career Development Award in Cardiovascular Medicine, American College of Cardiology Foundation (2004)

Along with his work at Massachusetts General Hospital, Dr. Wu is also:

  • Investigator with the Harvard Stem Cell Institute
Hub Site: 
04-Joseph Wu
research focus: 

Dr. Wu’s research focuses on identifying mechanisms responsible for heart formation and for human congenital heart disease, the most common cause of still-births in the U.S. and one of the major contributors to morbidity and mortality in infants and toddlers.

He believes that by understanding the mechanisms regulating growth and differentiation of heart precursor cells during early embryonic development, they can then apply these principles to understand the pathogenesis of adult onset heart diseases such as heart failure and arrhythmia where re-activation of early embryonic developmental program plays a central role.

Recent publications: 
Selected publications related to PCBC project:Chen, J.X., Krane, M., Deutsch, M.A., Li, Wang, Rav-Acha, M., Karra, S., Gregoire, S., Engels, M., Kuppusamy, R., Abel, E.D., Wu, J.C., Milan, D.A., Wu, S.M. Inefficient reprogramming of fibroblasts into cardiomyocytes using Gata4/Mef2c/Tbx5. Circ. Res. In press. Kuppusamy, R., Engels, M., Wu, S.M. Generation of iPS cells from mouse, rat, pig, and human fibroblasts. Curr Protoc Mol Biol. 2012; 97:23.15.1-23.Wu, S.M. and Hochedlinger, K. Harnessing the potential of induced pluripotent stem cells in regenerative medicine. Nature Cell Biol. 2011; 13(5):497-505.Sturzu, A. and Wu, S.M. Developmental and regenerative biology of multipotent cardiovascular progenitor cells. Circ Res. 2011; 108(3):353-64. Pijnappels, D.A., Gregoire, S., Wu, SM. Integrated aspects of cardiac cell therapy. Ann. N.Y. Acad. Sci. 2010; 1188:7-14. [[|Abstract PubMed]]Domian, IJ., Chiravuri, M., van der Meer, P., Feinberg, AW., Shi, X., Ying, C., Wu, SM., Parker, KK., Chien, KR. Committed ventricular progenitors in the Islet-1 lineage expand and assemble into functional ventricular heart muscle. Science. 2009; 326(5951):426-9. [[|Abstract]]Zhou B, Ma Q, Rajagopal S, Wu SM, Domian I, Rivera-Feliciano J, Jiang D, von Gise A, Ikeda S, Chien KR, Pu WT. Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart. Nature. 2008 Jul 3; 454(7200):109-13. [[|Abstract]]Wu SM. Mesp1 at the heart of mesoderm lineage specification. Cell Stem Cell. 2008 Jul 3; 3(1):1-2. [[|Abstract]]Karra R, Wu SM. Multipotent stem cells in cardiac regenerative therapy. Regen Med. 2008 Mar; 3(2):189-98. [[|Abstract]]Wu SM, Chien KR, Mummery C. Origins and fates of cardiovascular progenitor cells. Cell. 2008 Feb 22; 132(4):537-43. [[|Abstract]]Wu SM, Fujiwara Y, Cibulsky SM, Clapham DE, Lien CL, Schultheiss TM, Orkin SH. Developmental origin of a bipotential myocardial and smooth muscle cell precursor in the mammalian heart. Cell. 2006 Dec 15; 127(6):1137-50. [[|Abstract]]
Lokey Stem Cell Building, Room G1120A, 265 Campus Drive, Stanford, CA 94305
Group Name: 
Heart Group
Profile Page Photo: 
Sean Wu, M.D., Ph.D.

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