Punam Malik

Main Profile

Full Name and Degrees: 

Punam Malik, M.D.

Member Role: 

Principal Investigator

Institutional affiliation: 

CCHMC

Research hub: 

Cell Characterization Core

Hub Site: 

None

Objective: 

Punam Malik, M.D. Cincinnati Children's Hospital Medical Center Professor of Pediatrics, Exp. Hem. & Cancer Bio. -Molecular Genetics Program Leader, Hematology and Gene Therapy Program Director, Translational Core Laboratories 3333 Burnet Ave. ML 7013 Cincinnati, Ohio 45229 Office # (513)636-8588 Fax # (513)636-1330 Punam.Malik@cchmc.org

research focus: 

Lineage specific differentiation of human progenitors and developed human and murine models of human erythropoiesis. Hemoglobinopathies, including genetic therapies, and translating novel therapies from the bench to bedside. Director of the Translational Core at CCHMC, the Director Cell and Gene Therapy Matrix of the CTSA at Cincinnati.

Recent publications: 

1) Patel N, Sundaram N, Yang M, Madiagn C, Kalra VK and Malik, P. Placenta growth factor (PIGF), a novel inducer of plasminogen activator inhibitor-1 (PAI-1) in sickle cell disease (SCD). J Biol Chem, May 28;285(22):16713-22. 2010. PMID: 20351105 2) Trobridge GD, Beard BC, Gooch C, Wohlfahrt M, Olsen M, Fletcher J, Malik P and Kiem H-P. Efficient Transduction of Pigtailed Macaque Hematopoietic Repopulation Cells and HIV-based Lentiviral Vectors. Blood 111:5537-5543; 2008. PMID: 18388180 3) Perumbeti A, Higashimoto T, Urbinati F, Franco R, Meiselman HJ, Witte D, Malik P. A novel human gamma-globin gene vecxtor for genetic correction of sickle cell anemia in a humanized sickle mouse model: critical determinants for successful correction. Blood. Aug 6: 114(6):1174-85. 2009. PMID: 19474450 4) Sundaram N, Tailor A, Mendelsohn L, Wansapura J, Wang X, Higashimoto T, Pauciulo MW, Gottliebson W, Kalra VK, Nichols WC, Kato GJ, Malik P. High levels of placenta growth factor in sickle cell disease promote pulmonary hypertension. Blood. Jul 8;116(1):109-12. 2010. PMID: 20335221

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