mponcz

Main Profile

Full Name and Degrees:

Mortimer Poncz, M.D.

Member Role:

Principal Investigator

Institutional affiliation:

Children's Hospital of Philadelphia

Research hub:

ESC Platelet Therapeutics

Hub Site:

01-Mortimer Poncz

research focus:

Megakaryocyte and platelet biology

Recent publications:

120) Gregory GD, Miccio A, Bersenev A, Wang Y, Hong W, Zhang Z, Poncz M, Tong W, Blobel GA. FOG1 requires NuRD to promote hematopoiesis and maintain lineage fidelity within the megakaryocytic-erythroid compartment. Blood 2010;115:2156-66.[PMID 20065294] 121) Zaitzev S, Spitzer D, Murciano JC, Ding BS, Tliba S, Kowalska MA, Bdeir K, Kuo A, Stepanova V, Atkinson JP, Poncz M, Cines DB, Muzykantov VR. Targeting of a mutant plasminogen activator to circulating red blood cells for prophylactic fibrinolysis. J Pharmacol Exp Ther 2010;332:1022-31. [PMID19952305] 122) Miccio A, Wang Y, Hong W, Gregory GD, Wang H, Yu X, Choi JK, Shelat S, Tong W, Poncz M, Blobel GA. NuRD mediates activating and repressive functions of GATA-1 and FOG-1 during blood development. EMBO J 2010;29:442-56. [PMID19927129] 123) Rauova L, Hirsch JD, Greene TK, Zhai L, Hayes VM, Kowalska MA, Cines DB, Poncz M. Monocyte-bound PF4 in the pathogenesis of heparin-induced thrombocytopenia. Blood 2010;116:5021-31. [PMID20724543] 124) Mei J, Liu Y, Dai N, Favara M, Greene T, Jeyaseelan S, Poncz M, Lee JS, Worthen GS. CXCL5 regulates chemokine scavenging and pulmonary host defense to bacterial infection. Immunity 2010;33:106-17. [PMID20643340] 125) Fuentes R, Wang Y, Hirsch J, Wang C, Rauova L, Worthen GS, Kowalska MA, Poncz M. Infusion of mature megakaryocytes into mice yields functional platelets. J Clin Invest 2010;120:3917-22. [PMC2964983] 126) Greene TK, Wang C, Hirsch JD, Zhai L, Gewirtz J, Thornton MA, Miao HZ, Pipe SW, Kaufman RJ, Camire RM, Arruda VR, Kowalska MA, Poncz. In vivo efficacy of platelet-delivered, high specific activity factor VIII. Blood 2010;116:6114-22 [20852129]. 127) Zaitsev S, Spitzer D, Murciano JC, Ding BS, Tliba S, Kowalska MA, Marcos-Contreras OA, Kuo A, Stepanova V, Atkinson JP, Poncz M, Cines DB, Muzykantov VR. Sustained thromboprophylaxis mediated by an RBC-targeted pro-urokinase zymogen activated at the site of clot formation. J Pharmacol Exp Ther 2010;332:1022-31. [PMC2835436] 128) Mei J, Liu Y, Dai N, Favara M, Greene T, Jeyaseelan S, Poncz M, Lee JS, Worthen GS. CXCL5 regulates chemokine scavenging and pulmonary host defense to bacterial infection. Immunity 2010;33:106-17. [PMID20643340] 129) Rauova L, Hirsch JD, Greene TK, Zhai L, Hayes VM, Kowalska MA, Cines DB, Poncz M. Monocyte-bound PF4 in the pathogenesis of heparin-induced thrombocytopenia. Blood 2010;11623:5021-31. [PMID20724543] 130) Stolla M, Stefanini L, Roden RC, Chavez M, Hirsch J, Greene T, Ouellette TD, Maloney SF, Diamond SL, Poncz M, Woulfe DS, Bergmeier W. The kinetics of {alpha}IIb{beta}3 activation determines the size and stability of thrombi in mice: implications for antiplatelet therapy. Blood 2011;117:1005-13. [PMID20971951]

Address:

Mortimer Poncz, M.D. Division Chief Pediatric Hematology The Children's Hospital of Philadelphia 3615 Civic Center Blvd ARC; Rm 317 Philadelphia, PA 19104 Tel 2155903574 Cell 6108887442 Fax 2674265476

Phone:

Tel 2155903574 Cell 6108887442

Fax:

Fax 2674265476

Topic:

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