Mervin Yoder

Mervin Yoder's picture

Main Profile

Full Name and Degrees: 
Mervin C. Yoder, M.D.
Member Role: 
Co-PI/Co-Investigator
Institutional affiliation: 
IU
Hub Site: 
09-Irwin Bernstein
Objective: 

Mervin C. Yoder, M.D.
IU School of Medicine
Richard and Pauline Klingler Professor, IU School of Medicine
Professor, Department of Biochemistry and Molecular Biology
Associate Chair for Basic Research, Department of Pediatrics
R4 W125
1044 W. Walnut Street
Indianapolis, Indiana 46202

Office # (317)274-4738
Fax # (317)274-8679
Myoder@iupui.edu

research focus: 

HSC and endothelial biology development of innovative means to myeloablate newborn pups in utero to permit HSC engraftment. Define the site of emergence of the earliest long-term engrafting HSC in the murine system. Developed innovative imaging studies that have changed the paradign for understanding how the yolk sac blood islands develop with distinct origins of primitive hematopoietic and angioblastic endothelial elements. Helped re-define the field of endothelial progenitor cell biology. Only vascular endothelial-derived or rare circulating endothelial cells with colony forming activity serve to form the new vessels in tissues and organs.

Recent publications: 
1.) Yoder MC, Mead LE, Prater D, Krier TR, Mroueh K, Li F, Krasich R, Temm CJ, Prchal J, Ingram DA. Re-defining endothelial progenitor cells via clonal analysis and hematopoietic stem/progenitor cell principles. Blood 109(5):1801-1809, 2007. PMCID: PMC180167 2.) Yoshimoto M, Porayette P, Yoder MC. Overcoming obstacles in the search for the site of stem cell emergence. Cell Stem Cell 3(6):583-6, 2008. PMCID: 2756073 3.) Rhodes KE, Wang Y, Gekas C, Lux CT, Montecino-Rodriquez E, Francis CS, Orkin SH, Yoder MC, and Mikkola HKA. Hematopoietic stem cells emerge in the placental vasculature in the absence of circulation. Cell Stem Cells 2:252-263, 2008. NIHMSID # 43492 4.) Adamo L, Naveiras O, Wenzel PL, McKinney-Freeman S, Mack PJ, Gracia-Sancho J, Suchy-Dicey A, Yoshimoto M, Lensch MW, Yoder MC, García-Cardeña G, Daley GQ. Biomechanical forces promote embryonic haematopoiesis. Nature. 2009 Jun 25;459(7250):1131-5
Profile Page Photo: 
Mervin C. Yoder, M.D.

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