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Mehdi Keddache

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Mehdi A. Keddache
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Mehdi A. Keddache
Cincinnati Children's Hospital Medical Center
Coordinator, CCHMC DNA Sequencing and Genotyping Facility
3333 Burnet Ave.
ML 7016
Cincinnati, Ohio 45229

Office # (513)636-0122
Fax # (513)636-0124

research focus: 

Bioinformatics, DNA sequencing and genotyping laboratory techniques. DNA Core facility genetic data generation CLIA certified facility, sequencing service running on a fast turnaround schedule. SNP genotypes and CNV detection. Resequence specific areas of the genome without PCR optimization. Transcriptome analysis at the mRNA level (mRNA-seq) and microRNA level (shortRNA-seq). Suggest the most appropriate data generation path (long read nextgen, short reads nextgen or conventional sequencing, array or sequence based transcriptome analysis.

Recent publications: 
1.) Tomer G, Wetzler G, Keddache M, Denson LA. Polymorphisms in the IBD5 locus are associated with Crohn disease in pediatric Ashkenazi Jewish patients. J Pediatr Gastroenterol Nutr. 2009 May; 48(5):531-7 2.) Schorry EK, Keddache M, Lanphear N, Rubinstein JH, Srodulski S, Fletcher D, Blough-Pfau Rl, Grabowski GA. Genotype-phenotype correlations in Rubinstein-Taybi syndrome. Am J Med Genet A. 2008 Oct 1;146A(19):2512-9 3.) Holland KD, Kearney JA, Glauser TA, Buck G, Keddache M, Blankston JR, Glaaser IW, Kass RS, Meisler MH. Mutation of sodium channel SCN3A in a patient with cryptogenic pediatric partial epilepsy. Neurosci Lett. 2008 Mar 5’433(1):65-70. Epub 2008 Jan 11 4.) Martin LJ, Ramachandran V, Cripe LH, Hinton RB, Andelfinger G, Tabangin M, Shooner K, Keddache M, Benson DW. Evidence in favor of linkage to human chromosomal regions 18q, 5q and 13q for bicuspid aortic valve and associated cardiovascular malformations. Human Genet. 2007 Apr;121(2):275-84. Epub 2007 Jan 4
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Mehdi A. Keddache

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