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Main Profile

Full Name and Degrees: 
Jay W. Schneider, M.D., Ph.D.
Member Role: 
Principal Investigator
Institutional affiliation: 
UT Southwestern Medical Center
Hub Site: 
12-Jay Schneider
research focus: 

Research Interests
  • cardiomyocytes
  • cell fate mechanisms
  • chemical genetics/small molecules
  • neuronal and cancer stem cells
  • stem cells

Recent publications: 
Targeting Native Adult Heart Progenitors with Cardiogenic Small Molecules. Russell JL, Goetsch SC, Aguilar HR, Frantz DE, Schneider JW. ACS Chem Biol. 2012 Apr 13. [Epub ahead of print] PMID: 22413910 http://www.ncbi.nlm.nih.gov/pubmed/22413910 A small molecule differentiation inducer increases insulin production by pancreatic β cells. Dioum EM, Osborne JK, Goetsch S, Russell J, Schneider JW, Cobb MH. Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20713-8. Epub 2011 Dec 5. PMID: 22143803 http://www.ncbi.nlm.nih.gov/pubmed/22143803 Small-molecule blocks malignant astrocyte proliferation and induces neuronal gene expression. Zhang L, Li P, Hsu T, Aguilar HR, Frantz DE, Schneider JW, Bachoo RM, Hsieh J. Differentiation. 2011 Apr;81(4):233-42. Epub 2011 Mar 17. PMID: 21419563 http://www.ncbi.nlm.nih.gov/pubmed/21419563 A dynamic notch injury response activates epicardium and contributes to fibrosis repair. Russell JL, Goetsch SC, Gaiano NR, Hill JA, Olson EN, Schneider JW. Circ Res. 2011 Jan 7;108(1):51-9. Epub 2010 Nov 24. PMID: 21106942 http://www.ncbi.nlm.nih.gov/pubmed/21106942 The distinct metabolic profile of hematopoietic stem cells reflects their location in a hypoxic niche. Simsek T, Kocabas F, Zheng J, Deberardinis RJ, Mahmoud AI, Olson EN, Schneider JW, Zhang CC, Sadek HA. Cell Stem Cell. 2010 Sep 3;7(3):380-90. PMID: 20804973 http://www.ncbi.nlm.nih.gov/pubmed/20804973
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Jay W. Schneider, M.D., Ph.D.

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