Jose Cancelas

Main Profile

Full Name and Degrees: 

Jose A. Cancelas, M.D., Ph.D.

Member Role: 

Principal Investigator

Institutional affiliation: 

CCHMC

Research hub: 

Cell Characterization Core

Hub Site: 

None

Objective: 

Jose A. Cancelas, M.D., Ph.D. Cincinnati Children's Hospital Medical Center Stem Cell Program Leader, Division Experimental Hematology, Cancer & Blood Diseases Institute 3333 Burnet Ave. ML 7013 Cincinnati, Ohio 45229 Office # (513)803-0939 Fax # (513)558-1522 Jose.Cancelas@cchmc.org

research focus: 

Immunophentoypic analysis of hematopoietic stem cells and their lineages, and lung epithelial progenitors. Hematopoiesis, including hematopoietic and leukemic stem cell biology, myelopoiesis, erythropoiesis and red cell storage. Dissected out Rho GTPase-dependent pathways in normal and leukemic hematopoietic stem cells and progenitors in relation to cell proliferation, survival, engraftment and cell polarity. Development of novel blood and cell therapy products and analysis in vivo in animal models and in clinical trials.

Recent publications: 

1) Cancelas JA, Lee AW, Prabhakar R, et al. RacGPases differentially integrate signals regulating hematopoietic stem cell localization. Nat Med Aug 2005;11(8):886-91. Epub 2005 July 17. PMID: 16025125 2) Thomas EK*, Cancelas JA*, Chae H-D, et al. Rac guanosine triphosphatases represent integrating molecular therapeutic targes for BCR-ABL-induced myeloproliferative disease. *TEK and JAC contributed equally to this manuscript. Cancer Cell, 2007 Nov;12(5):467-78. PMID: 17996650 3) Yamada Y, Sanchez-Aguilera A, Brant EB, et al. FIP1L1/PDGFR, synergizes with SCF to induce systemic mastocytosis in a murine model of chronic eosinophilic leukemia/hypereosinophilic syndrome. Blood 2008;112(6):2500-7. PMID: 18539901 PMC NA 4) Sengupta A, Arnett J, Dunn S, Williams DA, Cancelas JA. Rac2 GTPase deficiency depletes BCR-ABL leukemic stem cells and progenitors in vivo. Blood 2010 Epub Apr 20. PMID 20407032

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