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Main Profile

Full Name and Degrees: 
Joseph Wu, M.D., Ph.D.
Member Role: 
Principal Investigator
Institutional affiliation: 
 Clinical Focus
  • Cardiovascular Disease
  •  Congenital Heart Disease (Adult)
  •  Echocardiography
Administrative Appointments
  • Editorial Board, Journal Clinical Investigation (2012 - present)
  • Editorial Board, Circulation Research (2011 - present)
  • Editorial Board, Stem Cell Research (2011 - present)  
  • Editorial Board, Molecular Therapy (2011 - present)
  • Editorial Board, Human Gene Therapy (2009 - present)
Honors and Awards
  • Elected to American Society Clinical Investigators, ASCI (2012)
  • Bernard and Joan Marshall Research Excellence Prize, British Society for Cardiovascular Research (2011)
  • Presidential Early Career Award for Scientists and Engineers (PECASE), White House Office of Technology (2010)
  • NIH Transformative R01 Award, National Institutes of Health (2009-2014)
  • NIH Director's New Innovator Award, National Institutes of Health (2008-2013)
Professional Education
  • Board Certification: Cardiovascular Disease, American Board of Internal Medicine (2004) 
  • Fellowship: UCLA Medical Center CA (2004) 
  • Residency: UCLA Medical Center CA (1999) 
  • Medical Education: Yale University School of Medicine-Graduate CT (1997) 
  • MD: Yale University, Medicine (1997) 
Additional links: 
Hub Site: 
04-Joseph Wu
research focus: 

 Current Research Interests

My lab works on biological mechanisms of adult stem cells, embryonic stem cells, and induced pluripotent stem cells. We use a combination of gene profiling, tissue engineering, physiological testing, and molecular imaging technologies to better understand stem cell biology in vitro and in vivo. For adult stem cells, we are interested in monitoring stem cell survival, proliferation, and differentiation. For ESC, we are currently studying their tumorigenicity, immunogenicity, and differentiation. For iPSC, we are working on novel derivation techniques. We also work on development of novel vectors and therapeutic genes for cardiovascular gene therapy applications.

Recent publications: 
 Patient-specific induced pluripotent stem cells as a model for familial dilated cardiomyopathy.Sun N, Yazawa M, Liu J, Han L, Sanchez-Freire V, Abilez OJ, Navarrete EG, Hu S, Wang L, Lee A, Pavlovic A, Lin S, Chen R, Hajjar RJ, Snyder MP, Dolmetsch RE, Butte MJ, Ashley EA, Longaker MT, Robbins RC, Wu JC. Sci Transl Med. 2012; 4 (130): 130ra47 AbstractProduction of de novo cardiomyocytes: human pluripotent stem cell differentiation and direct reprogramming. Burridge PW, Keller G, Gold JD, Wu JC. Cell Stem Cell. 2012; 10 (1): 16-28 AbstractAn antibody against SSEA-5 glycan on human pluripotent stem cells enables removal of teratoma-forming cells. Tang C, Lee AS, Volkmer JP, Sahoo D, Nag D, Mosley AR, Inlay MA, Ardehali R, Chavez SL, Pera RR, Behr B, Wu JC, Weissman IL, Drukker M. Nat Biotechnol. 2011; 29 (9): 829-34 AbstractShort-term immunosuppression promotes engraftment of embryonic and induced pluripotent stem cells. Pearl JI, Lee AS, Leveson-Gower DB, Sun N, Ghosh Z, Lan F, Ransohoff J, Negrin RS, Davis MM, Wu JC. Cell Stem Cell. 2011; 8 (3): 309-17 Abstract Single cell transcriptional profiling reveals heterogeneity of human induced pluripotent stem cells. Narsinh KH, Sun N, Sanchez-Freire V, Lee AS, Almeida P, Hu S, Jan T, Wilson KD, Leong D, Rosenberg J, Yao M, Robbins RC, Wu JC. J Clin Invest. 2011; 121 (3): 1217-21 Abstract 
Lorry Lokey Stem Cell Building 265 Campus Drive, G1120B A260 Stanford, CA 94305
(650) 723-2246
(650) 723-0234
Profile Page Photo: 
Joseph Wu, MD, PhD

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