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James Wells

James Wells's picture

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Full Name and Degrees: 
James M. Wells, Ph.D
Member Role: 
Co-PI/Co-Investigator
Institutional affiliation: 
CCHMC
Hub Site: 
None
Objective: 

James M. Wells, Ph.D
Cincinnati Children's Hospital Medical Center
Associate Professor, Division of Developmental Biology
3333 Burnet Ave.
ML 7007
Cincinnati, Ohio 45229

Office # (513)636-8767
Fax # (513)636-4317
James.Wells@cchmc.org

research focus: 

Understanding the molecular basis of endoderm organ development and using this a s a molecular framework to direct the differentiation of human embryonic and induced pluripotent stem cells (iPSCs) into pancreatic, liver and intestinal tissue. Establish a human pluripotent stem cell facility (PSCF) Facility basic and future translational research in human pluriopotent stem cells. Generate iPSCs from normal and patient samples for basic research, for banking and for ultimate clinical trials. Identify methods for improved differentiation of PSCs into organ-specific stem and progenitor cells. Develop GMP methods for generating iPSCs and their differentiated progeny. Develop methods for safe nuclear reprogramming.

Recent publications: 
1.) Spence, J. R. and Wells J. M. (2007) Translational embryology: Using embryonic principles to generate pancreatic endocrine cells from embryonic stem cells. Dev Dyn. 236:3218. PMID: 17973329 2.) Mayhew, C. N. and Wells J. M. (2009). Converting human pluripotent stem cells into beta cells: Recent advances and future challenges. Curr Opin Organ Transplant. 15:54-60. PMID: 19855279 3.) Lin SC, Wani MA, Whitsett JA, Wells JM. Klf5 regulates lineage formation in the pre-implantation mouse embryo. Development. 2010 Dec;137(23):3953-63 4.) Spence JR, Mayhew CN, Rankin SA, Kuhar MF, Vallance JE, Tolle K, Hoskins EE, Kalinichenko VV, Wells SI, Zorn AM, Shroyer NF, Wells JM. Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro. Nature. 2010 Dec 12. [Epub ahead of print]
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James M. Wells, Ph.D

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