ibernstein

Main Profile

Full Name and Degrees:

Irwin D. Bernstein, M.D.

Member Role:

Principal Investigator

More Info:

Irwin Bernstein: Fred Hutchinson Cancer Research Center

Institutional affiliation:

Fred Hutchinson Cancer Research Center

Additional links:

[[http://www.lls.org/all_page?item_id=223685|The Leukemia and Lymphoma Society]]

Research hub:

Wnt and Notch Progenitor Expansion

Hub Site:

09-Irwin Bernstein

Objective:

Dr. Irwin Bernstein (Fred Hutchinson Cancer Research Center) and Dr. Edward Morrisey (University of Pennsylvania) endeavor to determine how certain signaling pathways affect cardiac and blood-forming cell development and cardiac regeneration and repair. The team will also study whether these pathways may be harnessed for therapeutic applications.

research focus:

Dr. Bernstein’s work focuses on normal and malignant hematopoietic development and targeted therapy of hematopoietic malignancies. His team is trying to develop less toxic and more effective immune-based therapies for treating advanced leukemia and lymphoma. More specifically:

Methods to direct primitive hematopoietic precursors to commit to a particular maturational pathway or to self-renew. (Focusing on the role of the Drosophila developmental gene and Notch.)

Conditions that lead to amplification of hematopoietic stem cell populations.

Clonal origin of AML. (Focusing on CD33+ progenitors and CD33- precursor cells.)

Developed FDA-approved conjugate. (Ablation of CD33+precursors would restore normal hematopoiesis in patients with AML.)

Exploring use of hematopoietic differentiation antigens as targets for the selective delivery of therapy to tumors. (Using radiolabeled antibodies.)

Recent publications:

Butler JM, Nolan DJ, Vertes EL, Varnum-Finney B, Kobayashi H, Hooper AT, Seandel M, Shido K, White IA, Kobayashi M, Witte L, May C, Shawber C, Kimura Y, Kitajewski J, Rosenwaks Z, Bernstein ID, Rafii S (2010) Endothelial Cells Are Essential for the Self-Renewal and Repopulation of Notch-Dependent Hematopoietic Stem Cells., Cell Stem Cell, 6 (3), 251-264 http://www.cell.com/cell-stem-cell/retrieve/pii/S1934590910000457 Delaney C, Heimfeld S, Brashem-Stein C, Voorhies H, Manger RL, Bernstein ID (2010) Notch-mediated Expansion of Human Cord Blood Progenitor Cells Capable of Rapid Myeloid Reconstitution., Nat Med, 16 (2) 232-6 http://www.nature.com/nm/journal/v16/n2/abs/nm.2080.html Dallas MH, Varnum-Finney BJ, Martin PJ, Bernstein ID (2007) Enhanced T Cell Reconstitution by Hematopoietic Progenitors Expanded Ex-Vivo Using the Notch Ligand Delta1., Blood, 109 (8), 3579-87 http://bloodjournal.hematologylibrary.org/cgi/content/abstract/109/8/3579 Delaney C, Varnum-Finney B, Aoyama K, Brashem-Stein C, Bernstein ID (2005) Dose-dependent effects of the Notch ligand Delta1 on ex vivo differentiation and in vivo marrow repopulating ability of cord blood cells., Blood, 106 (8), 2693-9 http://bloodjournal.hematologylibrary.org/cgi/content/abstract/106/8/2693 Dallas MH, Varnum-Finney B, Delaney C, Kato K, Bernstein ID (2005) Density of the Notch ligand Delta1 determines generation of B and T cell precursors from hematopoietic stem cells., J Exp Med, 201 (9), 1361-6 http://jem.rupress.org/content/201/9/1361.long

Address:

1100 Fairview Avenue N, D2-373, P.O. Box 19024, Seattle, WA, 98109

Phone:

(206) 667-4886

Fax:

(206) 667-6084

People:

blood-forming

cardiac regeneration and repair

cell development

delta

hematopoietic development