gdaley

Main Profile

Full Name and Degrees:

George Q. Daley, M.D., Ph.D.

Member Role:

Principal Investigator

More Info:

George Daley Lab

Institutional affiliation:

Children's Hospital Boston

Additional links:

[[http://www.childrenshospital.org/cfapps/research/data_admin/Site92/mainp...|Children's Hospital Boston]]
[[http://bcmp.med.harvard.edu/index.php?option=com_akostaff&Itemid=51&func...|Harvard Medical School]]
[[http://www.hhmi.org/news/daley_bg.html|Howard Hughes Medical Institute]]
[[http://hsci.harvard.edu/people/george-q-daley-md-phd|Harvard Stem Cell Institute]]

Research hub:

iPS and Progenitor Cell Models

Hub Site:

08-George Daley

Objective:

Dr. George Daley (Children's Hospital, Boston) and Dr. Kenneth Chien (Massachusetts General Hospital) hope to advance regenerative therapy of cardiac and blood disorders by developing iPSC models of human disease technology.

research focus:

Dr. Daley's work focuses on pluripotent stem cells, which have the potential to differentiate into all other cell types. More specifically:

Differentiation of hematopoietic (blood producing) stem cells from embryonic cells and induced pluripotent stem (iPS) cells
Self-renewal and differentiation of human ES and iPS cells.
Germ cell development.
Target-directed chemotherapy for chronic myelogenous leukemia (CML).

Recent publications:

Agarwal S, Loh Y-H, McLoughlin EM, Huang J, Park I-H, Miller JD, Huo H, Rosana Okuka M, Maria dos Reis RM, Loewer S, Ng, H-H, Keefe DL, Goldman FD, Klingelhutz AJ, Liu L, Daley GQ. Telomere elongation in dyskeratosis congenita induced pluripotent stem cells. Nature 2010 464(7286):292-6. http://www.nature.com/nature/journal/v464/n7286/full/nature08792.html West J, Viswanathan SR, Yabuuchi A, Takeuchi A, Cunniff K, Park IH, Sero JE, Perez-Atayde A, Frazier AL, Surani MA, Daley GQ. A role for Lin28 in primordial germ-cell development and germ-cell malignancy. Nature 2009 460(7257):909-13. http://www.nature.com/nature/journal/v460/n7257/full/nature08210.html Naveiras O, Nardi V, Wenzel PL, Fahey F, Daley GQ. Bone marrow adipocytes as negative regulators of the hematopoietic microenvironment. Nature 2009 Jul 9; 460(7252):259-63. http://www.nature.com/nature/journal/v460/n7252/full/nature08099.html Adamo L, Naveiras O, McKinney-Freeman S, Mack PJ, Suchy-Dicey A, Yoshimoto M, Lensch MW, Yoder MC, #García-Cardeña G, #Daley GQ. Biomechanical forces promote embryonic hematopoiesis. Nature 2009 Jun 25; 459(7250):1131-5. Epub 2009 May 13. *equal contribution/ #co-corresponding authors. http://www.nature.com/nature/journal/v459/n7250/full/nature08073.html Park I-H, Arora N, Huo H, Maherali N, Ahfeldt T, Shimamura A, Lensch MW, Cowan C, Hochedlinger K, Daley GQ. Disease-specific induced pluripotent stem cells. Cell 2008 134(5):877-86. http://www.cell.com/abstract/S0092-8674%2808%2901001-5 Viswanathan S, *Daley GQ, *Gregory RI. Selective blockade of microRNA processing by Lin-28. Science 2008 4; 320(5872):97-100 *co-corresponding authors. http://www.sciencemag.org/cgi/content/abstract/1154040 Lerou PH, Yabuuchi A, Shea J, Takeuchi A, Cimini T, Ince T, Ginsburg E, Racowsky C, Daley GQ. Human embryonic stem cell derivation using poor quality embryos. Nature Biotechnology 2008 26:212-4. http://www.nature.com/nbt/journal/v26/n2/abs/nbt1378.html Park I-H, Zhao R, West JA, Yabuuchi A, Huo H, Ince TA, Lerou PH, Lensch MW, and Daley GQ. Reprogramming of human somatic cells to pluripotency with defined factors. Nature 2008 451(7175):141-6. http://www.nature.com/nature/journal/v451/n7175/abs/nature06534.html Kim K, Lerou P, Yabuuchi A, Lengerke C, Ng K, West J, Kirby A, Daly M, Daley GQ. Histocompatible parthenogenetic murine embryonic stem cells. Science 2007 Jan 26; 315(5811):482-6. http://www.sciencemag.org/cgi/content/abstract/sci;315/5811/482 Geijsen N, Horoschak M, Kim K, Gribnau J, Eggan K, Daley GQ. Derivation of embryonic germ cells and male gametes from embryonic stem cells. Nature 2004; 427: 148-154. http://www.nature.com/nature/journal/v427/n6970/abs/nature02247.html Azam, M., Latek, RR, Daley, GQ. Mechanisms of autoinhibition and STI571/imatinib resistance revealed by mutagenesis of BCR/ABL. Cell 2003; 112: 831-43. http://www.cell.com/abstract/S0092-8674%2803%2900190-9 Rideout WB, Hochedlinger K, Kyba M, Daley GQ, Jaenisch R. Correction of a genetic defect by nuclear transplantation and combined cell and gene therapy. Cell 2002 109:17-27. http://www.cell.com/abstract/S0092-8674%2802%2900681-5 Kyba M, Perlingeiro RCR, Daley GQ. HoxB4 confers definitive lymphoid-myeloid engraftment potential on embryonic stem cells and yolk sac hematopoietic progenitors. Cell 2002 109:29-37. http://www.cell.com/abstract/S0092-8674%2802%2900680-3

Address:

300 Longwood Avenue, 1 Blackfan Circle, Karp 7 Boston, MA 02115

Phone:

(617) 919-2013

Fax:

(617) 730-0222

People:

cardiac and blood disorders

chronic myelogenous leukemia

CML

differentiation

embryonic stem (ES) cells