emorrisey

Main Profile

Full Name and Degrees: 

Edward E. Morrisey, Ph.D.

Member Role: 

Lead Principal Investigator

More Info: 

Morrisey Lab

Institutional affiliation: 

University of Pennsylvania

Additional links: 

• [[http://www.med.upenn.edu/apps/faculty/index.php/g20000320/p1299|Edward Morrisey: University of Pennsylvania]]

Research hub: 

Wnt and Notch Progenitor Expansion

Hub Site: 

14-Edward Morrisey

Objective: 

Dr. Edward Morrisey (University of Pennsylvania) and Dr. Irwin Bernstein (Fred Hutchinson Cancer Research Center) will work to determine how certain signaling pathways affect cardiac and blood-forming cell development and cardiac regeneration and repair.

research focus: 

Dr. Morrisey’s work focuses on how signaling and transcription factor pathways integrate to promote the expansion and differentiation of tissue specific progenitors within the lung and heart.

His lab has identified several transcription factors and signaling molecules that are important for lung and cardiovascular development including:

• the Wnt signal transduction pathway
• zinc finger transcription factor GATA-6
• transcription factor Foxp1/2/4

The goal is to better understand how the lung and heart respond to injury and to identify ways to promote proper regeneration and repair in these tissues.

Recent publications: 

Foxp1/2/4-NuRD interactions regulate gene expression and epithelial injury response in the lung via regulation of IL-6. Chokas AL, Trivedi CM, Lu MM, Tucker PW, Li S, Epstein JA, Morrisey EE. J Biol Chem. 2010 Feb 25. http://www.jbc.org/content/early/2010/02/24/jbc.M109.088468 Characterization and in vivo pharmacological rescue of a Wnt2-Gata6 pathway required for cardiac inflow tract development. Tian Y, Yuan L, Goss AM, Wang T, Yang J, Lepore JJ, Zhou D, Schwartz RJ, Patel V, Cohen ED, Morrisey EE. Dev Cell. 2010 Feb 16; 18(2):275-87. Abstract Preparing for the first breath: genetic and cellular mechanisms in lung development. Morrisey EE, Hogan BL. Dev Cell. 2010 Jan 19; 18(1):8-23. http://www.cell.com/developmental-cell/abstract/S1534-5807(09)00527-9 Goss, AM, Tian, Y, Tsukiyama, T, Cohen, ED, Zhou, D, Lu, MM, Yamaguchi, TP, and Morrisey, EE. Wnt2/2b and -catenin signaling are necessary and sufficient to specify lung progenitors in the foregut. Dev Cell 2009 17: 290-298. http://www.cell.com/developmental-cell/abstract/S1534-5807%2809%2900222-6 Evidence for coregulation of myocardial gene expression by MEF2 and NFAT in human heart failure. Putt ME, Hannenhalli S, Lu Y, Haines P, Chandrupatla HR, Morrisey EE, Margulies KB, Cappola TP. Circ Cardiovasc Genet. 2009 Jun; 2(3):212-9. Epub 2009 Mar 31. http://circgenetics.ahajournals.org/cgi/content/abstract/2/3/212 Cohen, ED, Ihida-Stansbury, K. Lu, MM, Jones, PL, Morrisey, EE. Wnt signaling regulates smooth muscle precursor development in the lung via a tenascin-C/platelet derived growth factor receptor pathway J. Clinical Investigation (2009) 119: 2538-2549. http://www.jci.org/articles/view/38079

Address: 

956 Biomedical Research Bldg II/III, 421 Curie Boulevard, Philadelphia, PA 19104

Phone: 

(215) 573-3010

Fax: 

(215) 573-2094

People: 

cardiovascular development

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