dsrivastava

Main Profile

Full Name and Degrees: 

Deepak Srivastava, M.D.

Member Role: 

Lead Principal Investigator

More Info: 

Srivastava Lab

Institutional affiliation: 

Gladstone Institute

Additional links: 

• Gladstone Institute of Cardiovascular Disease
• UCSF Tetrad Program
• UCSF Biomedical Sciences

Research hub: 

iPS Cells in Heart Disease

Hub Site: 

15-Deepak Srivastava

Objective: 

Dr. Deepak Srivastava (Gladstone Institutes) and Dr. Robert Robbins (Stanford University) plan to produce usable and reliable induced pluripotent stem cells that can be used for cell therapy in the heart.

research focus: 

Dr. Srivastava's work focuses on understanding the causes of heart disease and on using knowledge of cardiac developmental pathways to devise novel therapeutics for human cardiac disorders. Specifically, his lab's work includes:

• studying molecular events regulating early and late developmental decisions that instruct progenitor cells to adopt a cardiac cell fate and subsequently fashion a functioning heart
• seeking ways to use pathways to prevent congenital defects and treat heart disease
• identifying causes of human cardiovascular disease by applying modern technologies

Recent publications: 

Cordes KR, Sheehy NT, White M, Berry E, Morton SU, Muth AN, Lee T-H, Miano JM, Ivey KN, Srivastava D. (2009) miR-145 and miR-143 regulate smooth muscle cell fate and plasticity. Nature 460:705–710. Abstract Ieda M, Tsuchihashi T, Ivey KN, Ross RS, Hong T-T, Shaw RM, Srivastava D. (2009) Cardiac fibroblasts regulate myocardial proliferation through beta-1 integrin signaling. Dev. Cell 16:233-244. Abstract Fish JE, Santoro MM, Morton SU, Yu S, Yeh RF, Wythe JD, Ivey KN, Bruneau BG, Stainier DYR, Srivastva D. (2008) miR-126 regulates angiogenic signaling and vascular integrity. Dev. Cell 15:272-284. Abstract Ivey KN, Muth A, Arnold J, King FW, Yeh R-F, Fish JE, HSaio EC, Schwartz RJ, Conklin BR, Bernstein HS, Srivastava D. (2008) MicroRNA regulation of cell lineages in mouse and human embryonic stem cells. Cell Stem Cell 2:219-229. Abstract Zhao Y, Ransom JF, Li A, Vedantham V, von Drehle M, Muth AN, Tsuchihashi T, McManus MT, Schwartz RJ, Srivastava D. (2007) Dysregulation of cardiogenesis, cardiac conduction, and cell cycle in mice lacking miRNA-1-2. Cell 129:303–317. Abstract

Address: 

University of California, San Francisco, 1650 Owens Street, San Francisco, CA 94158

Phone: 

(415) 734-2716

Fax: 

(415) 355-0141

People: 

cardiac cell

heart disease

pathways

progenitor cells

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