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Main Profile

Full Name and Degrees: 
Carla F. Kim, Ph.D.
Member Role: 
Institutional affiliation: 
Children's Hospital Boston
Additional links: 
Hub Site: 
13-David Scadden
research focus: 

The broad interest of Dr. Kim’s lab is to characterize the biology of stem cells in normal tissue and in disease.  They have developed a method to isolate the first stem cell population from the adult murine lung, termed bronchioalveolar stem cells (BASCs).  BASCs are critically affected by an oncogenic K-ras mutation and may be the cell-of-origin of lung adenocarcinomas.  They use a combination of mouse genetics, cell biology and genomics approaches to elucidate the biology of these cells during homeostasis and tumorigenesis.  An understanding of stem cell functions and regulation in normal lung will be important for innovative approaches to examine the cellular and molecular basis of cancer and diseases that effect lung epithelia as well as serving to identify potential means of early detection and therapy.

Recent publications: 
Matrix modulation of compensatory lung regrowth and progenitor cell proliferation in mice. Hoffman AM, Shifren A, Mazan MR, Gruntman AM, Lascola KM, Nolen-Walston RD, Kim CF, Tsai L, Pierce RA, Mecham RP, Ingenito EP. Am J Physiol Lung Cell Mol Physiol. 2010 Feb; 298(2):L158-68. Epub 2009 Nov 13. Abstract Raiser DM, Zacharek SJ, Roach RR, Curtis SJ, Sinkevicius KW, Gludish DW, Kim CF. (2008) Stem cell biology in the lung and lung cancers: using pulmonary context and classic approaches. Cold Spring Harb Symp Quant Biol; 73:479-90. Epub 2008 Nov 21. Review. AbstractDovey J, Zacharek S, Kim CF*, Lees JA*. (2008). Bmi1 is critical for lung tumorigenesis and bronchioalveolar stem cell expansion. Proceedings of the National Academy of Sciences of the USA. 105:11857-11862. Abstract Kim CFB, Jackson EL, Woolfenden AE, Lawrence S, Babar I, Vogel S, Crowley D, Bronson RT, Jacks T. (2005). Identification of bronchioalveolar stem cells in normal lung and lung cancer. Cell, 121(6):823-835. Abstract
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Carla F. Kim, Ph.D.

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