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Main Profile

Full Name and Degrees: 
Benoit Bruneau, Ph.D.
Member Role: 
Affiliated Investigator
Institutional affiliation: 
Gladstone Institutes
Hub Site: 
15-Deepak Srivastava
research focus: 

Dr. Bruneau’s research focuses on heart development. More specifically:

  • transcriptional regulation of these processes
  • chromatin remodeling factors, which are critically relevant to heart development

The lab’s most recent findings have uncovered the fundamental identity of a heart cell.

They discovered that a simple combination of two transcription factors, Gata4 and Tbx5, and a chromatin remodeling protein, Baf60c, is sufficient to generate new beating cardiomyocytes from embryonic mouse tissue that normally would be fated to become blood or skeletal muscle.

Dr. Bruneau’s lab is now working to understand how this occurs and how it could be harnessed to generate new heart cells for regenerative purposes.

Another important finding for the lab recently was pinpointing Tbx5 as the first molecular link to the evolution of cardiac septation. The lab is now working to understand how septation forms and how it goes awry in congenital heart disease.

Recent publications: 
Koshiba-Takeuchi K, Mori AD, Kaynak BL, Cebra-Thomas J, Sukonnik T, Georges RO, Latham S, Beck L, Henkelman RM, Black BL, Olson EN, Wade J, Takeuchi JK, Nemer M, Gilbert SF, Bruneau BG (2009) Reptilian heart development and the molecular basis of cardiac chamber evolution. Nature 461:95–98. [[|Abstract]]Takeuchi JK, Bruneau BG (2009) Directed transdifferentiation of mouse mesoderm to heart tissue by defined factors. Nature 459:708–711. [[|Abstract]]
1650 Owens Street, Room 407, San Francisco, CA 94158
(415) 734-2712
(415) 355-0960
Profile Page Photo: 
Benoit Bruneau, Ph.D

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