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Full Name and Degrees: 
Antonis K. Hatzopoulos, Ph.D.
Member Role: 
Lead Principal Investigator
Institutional affiliation: 
Vanderbilt University

Dr. Antonis Hatzopoulos joins the Consortium from Vanderbilt University where he is Associate Professor of Medicine and Cell and Developmental Biology.

He received his bachelor’s degree from Aristotelion University of Thessaloniki in Greece and received his Ph.D. in molecular biology and cell biology from Northwestern University.

Hub Site: 
11-Antonis Hatzopoulos

Dr. Antonis Hatzopoulos (Vanderbilt University) will study the repair and regenerative properties of cardiac progenitor cells and investigate how disease affects their usefulness for therapeutic applications.

research focus: 

Dr. Hatzopoulos’s work focuses on the role of stem cells in cardiac development and regeneration.  He is a member of the Cardiovascular Cell Therapy Research Network (CCTRN), which has three Phase II clinical trials in progress.

His lab has worked on:

  • the mechanisms that regulate the initial recruitment of vascular progenitor cells to the heart and limbs in animal models of acute and chronic ischemia;
  • the application of progenitor cells as “Trojan horses” to invade and kill tumors by delivering toxic agents; 
  • the positive effects of progenitor cells on promoting angiogenesis and cell survival and suppressing apoptosis and inflammation;
  • the molecular and cellular mechanisms of cardiac and brain repair after injury.

His current work focuses on:

  • the biology and cardiogenic potential of embryonic stem cells; and
  • the intrinsic pathways of cardiac repair.
Recent publications: 
Boudoulas, KD, Hatzopoulos, AK. Cardiac repair and regeneration: the Rubik's cube of cell therapy for heart disease. Dis Model Mech, 2(7-8), 344-58, 2009. http://dmm.biologists.org/content/2/7-8/344.full.pdf |AbstractJoggerst, SJ, Hatzopoulos, AK. Stem cell therapy for cardiac repair: benefits and barriers. Expert Rev Mol Med, 11, e20, 2009. http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=5895376 Schulz, H, Kolde, R, Adler, P, Aksoy, I, Anastassiadis, K, Bader, M, Billon, N, Boeuf, H, Bourillot, PY, Buchholz, F, Dani, C, Doss, MX, Forrester, L, Gitton, M, Henrique, D, Hescheler, J, Himmelbauer, H, Hübner, N, Karantzali, E, Kretsovali, A, Lubitz, S, Pradier, L, Rai, M, Reimand, J, Rolletschek, A, Sachinidis, A, Savatier, P, Stewart, F, Storm, MP, Trouillas, M, Vilo, J, Welham, MJ, Winkler, J, Wobus, AM, Hatzopoulos, AK. The FunGenES database: a genomics resource for mouse embryonic stem cell differentiation. PLoS One, 4(9), e6804, 2009. http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0006804 Traverse, JH, Henry, TD, Vaughn, DE, Ellis, SG, Pepine, CJ, Willerson, JT, Zhao, DX, Piller, LB, Penn, MS, Byrne, BJ, Perin, EC, Gee, AP, Hatzopoulos, AK, McKenna, DH, Forder, JR, Taylor, DA, Cogle, CR, Olson, RE, Jorgenson, BC, Sayre, SL, Vojvodic, RW, Gordon, DJ, Skarlatos, SI, Moye'', LA, Simari, RD.  Rationale and design for TIME: A phase II, randomized, double-blind, placebo-controlled pilot trial evaluating the safety and effect of timing of administration of bone marrow mononuclear cells after acute myocardial infarction. Am Heart J, 158(3), 356-63, 2009. http://www.ahjonline.com/article/S0002-8703%2809%2900451-7/abstractBeck, H, Semisch, M, Culmsee, C, Plesnila, N, Hatzopoulos, AK. Egr-1 regulates expression of glial scar component phosphacan in astrocytes after experimental stroke. Am J Pathology, 173, 77-92, 2008. http://ajp.amjpathol.org/cgi/content/abstract/ajpath.2008.070648v1
MRB IV-P425C, 2213 Garland Ave, Nashville, TN 37232-6300
(615) 936-5529
(615) 936-1872
Profile Page Photo: 
Antonis K. Hatzopoulos, Ph.D.

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