Akt1/protein Kinase B Enhances Transcriptional Reprogramming of Fibroblasts to Functional Cardiomyocytes; Schneider Hub Site 12

After a heart attack, millions to billions of cardiomyocytes are lost. Because the adult mammalian heart possesses little regenerative potential, a precipitous loss of cardiac function ensues. Patients with heart failure could benefit from repopulating injured areas of the heart with functional cardiomyocytes. To date, cellular transplantation has been therapeutically unsuccessful. Direct lineage reprogramming offers a new approach to repopulate cardiomyocytes in the heart.

La Jolla Pharmaceutical Company and Vanderbilt University Enter Exclusive Research and License Agreement Covering Novel BMP Type-I Receptor Inhibitors

Dr. Charles Hong’s group at the Vanderbilt Hub has signed a licensing agreement for clinical development of novel small molecule BMP inhibitors for rare genetic disease called fibrodysplasia ossificans progressiva, muscular dystrophy and variety of cancers that are driven by aberrant BMP signaling.  Earlier versions of BMP inhibitors that the Hong group developed, such as dorsomorphin and DMH1, have been widely used to direct differentiation of pluripotent stem cells toward cardiovascular, neuronal and other lineages.

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Gremlin 2 Promotes Differentiation of Embryonic Stem Cells to Atrial Fate by Activation of the JNK Signaling Pathway

Top Ten Articles on the Biology of Embryonic and Induced Pluripotent Stem Cells – Journal of Stem Cells 2014-2015; Hatzopoulos Hub Site 11

Green Light for Transplantation Enhancement of Stem-Cell Engraftment in a Zebrafish Model

Leonard Zon, MD, Grousbeck Professor of Pediatric Medicine at Harvard Medical School, Investigator at Howard Hughes Medical Institute, Director of the Stem Cell Program, Children’s Hospital Boston, and colleagues have developed a novel competitive marrow transplantation system in adult zebrafish in which engraftment is measured by in vivo fluorescence imaging of the kidney — the adult haematopoietic site.

Identification of Specialized Progenitor Population Committed to Forming Cardiomyocytes Exclusively

Jonathan Epstein, MD, chair of the Cell and Developmental Biology Department, Ed Morrisey, PhD, the scientific director of the Institute for Regenerative Medicine, and other colleagues from the Perelman School of Medicine at the University of Pennsylvania, of PCBC Hub Site 14 have identified a specialized progenitor population that is committed exclusively to forming cardiomyoc

The Core Center of Excellence in Hematology (CCEH) at the Fred Hutchinson Cancer Research Center (FHCRC)

The Core Center of Excellence in Hematology (CCEH) was established in September 1999 with funding from NIDDK (http://cceh.fhcrc.org/).

NIH Genomic Data Sharing (GDS) Policy

To promote sharing of human and non-human genomic data and to provide appropriate protections for research involving human data, the National Institutes of Health (NIH) issued the Genomic Data Sharing (GDS) Policy on August 27, 2014, in the NIH Guide Grants and Contracts (available at http://grants.nih.gov/grants/guide/notice-files/NOT-OD-14-124.html). The GDS Policy is also available at http://gds.nih.gov/03policy2.html.

A microRNA-Hippo Pathway that Promotes Cardiomyocyte Proliferation and Cardiac Regeneration in Mice

A team led by Ed Morrisey, PhD, a professor of Medicine and Cell and Developmental Biology and the scientific director of the Institute for Regenerative Medicine in the Perelman School of Medicine at the University of Pennsylvania, has now shown that a subset of RNA molecules, called microRNAs, is important for cardiomyocyte cell proliferation during development and is sufficient to induce proliferation in cardiomyocytes in the adult heart.

NIH Funding Opportunity Announcements

NIH Big Data to Knowledge (BD2K) Enhancing Diversity in Biomedical Data Science (R25)

FOA #: RFA-MD-15-005

Transient delivery of modified mRNA encoding TERT rapidly extends telomeres in human cells

PCBC Investigator Helen Blau, professor of microbiology and immunology at Stanford University and director of the university's Baxter Laboratory for Stem Cell Biology, and colleagues have published an important discovery toward lengthening telomeres in The Federation of American Societies for Experimental Biology (FASEB) Journal (http://www.fasebj.org).

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