NIH Funding Opportunity Announcement – Administrative Supplements for Research on Sex/Gender (January 2016)

Funding Purpose: The Office of Research on Women's Health (ORWH) announces the availability of administrative supplements to support research highlighting the impact of sex/gender differences (or similarities) and/or sex and gender factors in human health and illness, including basic, preclinical, clinical and behavioral studies.

PCBC investigator, Dr. Leonard I. Zon, is awarded with the Knudson Award in Cancer Genetics

Dr. Leonard Zon, M.D., Director of the Stem Cell Program at Boston Children's Hospital and Grousbeck Professor of Pediatrics at Harvard Medical School, is the recipient of the 20th annual Alfred G. Knudson Award in Cancer Genetics from the National Cancer Institute. This award is presented annually to a scientist who has made outstanding research contributions to the field of cancer genetics.

More details:

PCBC Investigators Edit Genes to Treat Duchenne Muscular Dystrophy

Three research groups, working independently of one another, reported in Science on December 31, 2015, on the use of CRISPR/Cas9 to treat mice with defective dystrophin genes.

Message from the NHLBI Director: Promising News for Biomedical Science

The NHLBI Director, Gary Gibbons, MD, has released news that the FY2016 NIH budget will be $2 billion more than the FY2015 budget. He is pleased to announce the NHLBI's plan to set a payline for R01 grant applications at the 14th percentile, the highest payline in several years.

This upward trajectory will enable NHLBI investigators to seize unprecendented scientific opportunities that will turn discovery into the health of the nation.

Akt1/protein Kinase B Enhances Transcriptional Reprogramming of Fibroblasts to Functional Cardiomyocytes; Schneider Hub Site 12

After a heart attack, millions to billions of cardiomyocytes are lost. Because the adult mammalian heart possesses little regenerative potential, a precipitous loss of cardiac function ensues. Patients with heart failure could benefit from repopulating injured areas of the heart with functional cardiomyocytes. To date, cellular transplantation has been therapeutically unsuccessful. Direct lineage reprogramming offers a new approach to repopulate cardiomyocytes in the heart.

La Jolla Pharmaceutical Company and Vanderbilt University Enter Exclusive Research and License Agreement Covering Novel BMP Type-I Receptor Inhibitors

Dr. Charles Hong’s group at the Vanderbilt Hub has signed a licensing agreement for clinical development of novel small molecule BMP inhibitors for rare genetic disease called fibrodysplasia ossificans progressiva, muscular dystrophy and variety of cancers that are driven by aberrant BMP signaling.  Earlier versions of BMP inhibitors that the Hong group developed, such as dorsomorphin and DMH1, have been widely used to direct differentiation of pluripotent stem cells toward cardiovascular, neuronal and other lineages.

Read more via the link below:

Gremlin 2 Promotes Differentiation of Embryonic Stem Cells to Atrial Fate by Activation of the JNK Signaling Pathway

Top Ten Articles on the Biology of Embryonic and Induced Pluripotent Stem Cells – Journal of Stem Cells 2014-2015; Hatzopoulos Hub Site 11

Green Light for Transplantation Enhancement of Stem-Cell Engraftment in a Zebrafish Model

Leonard Zon, MD, Grousbeck Professor of Pediatric Medicine at Harvard Medical School, Investigator at Howard Hughes Medical Institute, Director of the Stem Cell Program, Children’s Hospital Boston, and colleagues have developed a novel competitive marrow transplantation system in adult zebrafish in which engraftment is measured by in vivo fluorescence imaging of the kidney — the adult haematopoietic site.

Identification of Specialized Progenitor Population Committed to Forming Cardiomyocytes Exclusively

Jonathan Epstein, MD, chair of the Cell and Developmental Biology Department, Ed Morrisey, PhD, the scientific director of the Institute for Regenerative Medicine, and other colleagues from the Perelman School of Medicine at the University of Pennsylvania, of PCBC Hub Site 14 have identified a specialized progenitor population that is committed exclusively to forming cardiomyoc

The Core Center of Excellence in Hematology (CCEH) at the Fred Hutchinson Cancer Research Center (FHCRC)

The Core Center of Excellence in Hematology (CCEH) was established in September 1999 with funding from NIDDK (


Copyright ©2013 NHLBI Progenitor Cell Biology Consortium.

University of Maryland School of Medicine logo

National Heart Blood and Lung Institute logo