Notice of Intent to Publish FOAs - Blood and Marrow Transplant Clinical Trials Network (BMT CTN)

The National Heart, Lung, and Blood Institute intends to publish two Funding Opportunity Announcements (FOA) to solicit applications for 1) a Data and Coordinating Center (DCC) and 2) for Core Clinical Centers of the Blood and Marrow Transplant Clinical Trials Network (BMT CTN). The goals of the BMT CTN are to advance hematopoietic cell transplantation (HCT) for all patients, but particularly for patients with rare and difficult to treat blood diseases. This will be accomplished by advancing traditional HCT approaches and by using novel cell and gene therapy approaches. 

Generating Trunk Neural Crest from Human Pluripotent Stem Cells

Bruce Conklin et al. reported on studies of retinoids and BMPs in the differentiation of human PSC to trunk neural crest cells and to sympathoadrenal lineages.

Stimulus-Triggered Acquisition of Pluripotency - The New Yorker

The New Yorker has just published, "The Stress Test: Rivalries, Intrigue and Fraud in the World of Stem-Cell Research" in the February 29, 2016, Annals of Science Issue. The article by Dana Goodyear tells the story of stimulus-triggered acquisition of pluripotency (STAP). PCBC U01 Hub Site Principal Investigator, George Daley, M.D., Ph.D., features prominently in this article.

Here is a link to the article: http://www.newyorker.com/magazine/2016/02/29/the-stem-cell-scandal

Hoxb5 Marks Long-term Haematopoietic Stem Cells and Reveals a Homogenous Perivascular Niche – Weissman Hub Site 07

Dr. Irv Weissman and colleagues reported that Hoxb5+ HSCs exhibit long-term reconstitution capacity in primary and secondary transplanted mouse models, in the February 2016 issue of Nature.

Click on the links below to read the full article and press release:

http://www.ncbi.nlm.nih.gov/pubmed/26863982

“Lineage Reprogramming of Fibroblasts into Proliferative Induced Cardiac Progenitor Cells by Defined Factors“ – Thomson Hub Site 02

Timothy Kamp, MD, co-director at the Stem Cell and Regenerative Medicine Center and researchers at the University of Wisconsin- Madison (Thomson Hub Site 02) report that the combination of cardiac factors and signaling molecules reprogram adult mouse fibroblasts into expandable induced cardiac progenitor cells (iCPCs) in the February 11, 2016 issue of Cell Stem Cell.

NIH Funding Opportunity Announcement – Administrative Supplements for Research on Sex/Gender (January 2016)

Funding Purpose: The Office of Research on Women's Health (ORWH) announces the availability of administrative supplements to support research highlighting the impact of sex/gender differences (or similarities) and/or sex and gender factors in human health and illness, including basic, preclinical, clinical and behavioral studies.

PCBC investigator, Dr. Leonard I. Zon, is awarded with the Knudson Award in Cancer Genetics

Dr. Leonard Zon, M.D., Director of the Stem Cell Program at Boston Children's Hospital and Grousbeck Professor of Pediatrics at Harvard Medical School, is the recipient of the 20th annual Alfred G. Knudson Award in Cancer Genetics from the National Cancer Institute. This award is presented annually to a scientist who has made outstanding research contributions to the field of cancer genetics.

More details:

http://www.eurekalert.org/pub_releases/2016-01/bch-nci011216.php

PCBC Investigators Edit Genes to Treat Duchenne Muscular Dystrophy

Three research groups, working independently of one another, reported in Science on December 31, 2015, on the use of CRISPR/Cas9 to treat mice with defective dystrophin genes.

Message from the NHLBI Director: Promising News for Biomedical Science

The NHLBI Director, Gary Gibbons, MD, has released news that the FY2016 NIH budget will be $2 billion more than the FY2015 budget. He is pleased to announce the NHLBI's plan to set a payline for R01 grant applications at the 14th percentile, the highest payline in several years.

This upward trajectory will enable NHLBI investigators to seize unprecendented scientific opportunities that will turn discovery into the health of the nation.

Akt1/protein Kinase B Enhances Transcriptional Reprogramming of Fibroblasts to Functional Cardiomyocytes; Schneider Hub Site 12

After a heart attack, millions to billions of cardiomyocytes are lost. Because the adult mammalian heart possesses little regenerative potential, a precipitous loss of cardiac function ensues. Patients with heart failure could benefit from repopulating injured areas of the heart with functional cardiomyocytes. To date, cellular transplantation has been therapeutically unsuccessful. Direct lineage reprogramming offers a new approach to repopulate cardiomyocytes in the heart.

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