Direct, chemical reprogramming of mouse and human skin cells into cardiac muscle and neural cells – (Srivastava Hub Site 15)

Sheng Ding, PhD, and colleagues’ chemical reprogramming of skin cells into heart cells and brain cells was published recently in Science and Cell Stem Cell.

Click on the links below for articles and press releases:

"Conversion of Human Fibroblasts into Functional Cardiomyocytes by Small Molecules“

Videos Posted from the 2016 Drug Discovery Conference at Stanford University, March 29, 2016 – Wu Hub Site 04

The Stanford Cardiovascular Institute, Wu Hub Site 04, hosted a Cardiovascular Tissue Engineering Symposium and Drug Discovery Conference on March 29, 2016. Experts in drug discovery discussed advances in research and technology.
 

Topics covered included:

Lung Epithelium in Health & Disease Conference _July 31-August 5, 2016

Dr. Carla Kim is organizing a FASEB “Lung Epithelium in Health & Disease” conference.

This conference will take place from July 31- August 5, 2016 in the Horowitz Performing Arts Hall and Nita Choukas Theater, Saxtons River, Vermont.

The deadline for abstract submission is June 26, 2016.

Abstracts from PCBC investigators will be welcome.

Keynote speaker is Dr. Ed Morrisey from Hub Site 14.

What is Good Science: A response to the New Yorker article “The Stress Test”

What is Good Science: A response to the New Yorker article “The Stress Test”

By Lehanna Sanders, Vanderbilt University, Hatzopoulos Hub 11

Illustration by Chad Hagen

PCBC U01 Hub Site No Cost Extension Requests

PCBC U01 Hub Site awards terminate April 30, 2016. U01 Hub Sites may request no cost extensions from May 1, 2016 - April 30, 2017, if they have funds remaining from their original awards and work to accomplish from the original U01 Hub Site project.

To summarize and clarify our discussions on the PCBC Steering Committee conference call, PCBC U01 Hub Site Principal Investigators requesting no cost extensions should proceed as follows:

Notice of Intent to Publish FOAs - Blood and Marrow Transplant Clinical Trials Network (BMT CTN)

The National Heart, Lung, and Blood Institute intends to publish two Funding Opportunity Announcements (FOA) to solicit applications for 1) a Data and Coordinating Center (DCC) and 2) for Core Clinical Centers of the Blood and Marrow Transplant Clinical Trials Network (BMT CTN). The goals of the BMT CTN are to advance hematopoietic cell transplantation (HCT) for all patients, but particularly for patients with rare and difficult to treat blood diseases. This will be accomplished by advancing traditional HCT approaches and by using novel cell and gene therapy approaches. 

Generating Trunk Neural Crest from Human Pluripotent Stem Cells

Bruce Conklin et al. reported on studies of retinoids and BMPs in the differentiation of human PSC to trunk neural crest cells and to sympathoadrenal lineages.

Stimulus-Triggered Acquisition of Pluripotency - The New Yorker

The New Yorker has just published, "The Stress Test: Rivalries, Intrigue and Fraud in the World of Stem-Cell Research" in the February 29, 2016, Annals of Science Issue. The article by Dana Goodyear tells the story of stimulus-triggered acquisition of pluripotency (STAP). PCBC U01 Hub Site Principal Investigator, George Daley, M.D., Ph.D., features prominently in this article.

Here is a link to the article: http://www.newyorker.com/magazine/2016/02/29/the-stem-cell-scandal

Hoxb5 Marks Long-term Haematopoietic Stem Cells and Reveals a Homogenous Perivascular Niche – Weissman Hub Site 07

Dr. Irv Weissman and colleagues reported that Hoxb5+ HSCs exhibit long-term reconstitution capacity in primary and secondary transplanted mouse models, in the February 2016 issue of Nature.

Click on the links below to read the full article and press release:

http://www.ncbi.nlm.nih.gov/pubmed/26863982

“Lineage Reprogramming of Fibroblasts into Proliferative Induced Cardiac Progenitor Cells by Defined Factors“ – Thomson Hub Site 02

Timothy Kamp, MD, co-director at the Stem Cell and Regenerative Medicine Center and researchers at the University of Wisconsin- Madison (Thomson Hub Site 02) report that the combination of cardiac factors and signaling molecules reprogram adult mouse fibroblasts into expandable induced cardiac progenitor cells (iCPCs) in the February 11, 2016 issue of Cell Stem Cell.

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