Endoglin Integrates BMP and Wnt Signalling to Induce Haematopoiesis through JDP2

June Baik, Rita Perlingeiro, James Thomson, and colleagues reported on BMP and Wnt signalling pathways and endoglin in cardiac and haematopoietic lineage specification, in the October 2016 issue of Nature Communications.

Click on the links below to read the full article and press release:

http://www.nature.com/articles/ncomms13101

https://www.sciencedaily.com/releases/2016/10/161007120621.htm

Single-Cell Analysis of Mixed-Lineage States Leading to a Binary Cell Fate Choice – PCBC Bioinformatics Core

Nathan Salomonis, PhD, Bruce Aronow, PhD, and colleagues report on single-cell RNA sequencing, iterative clustering and guide-gene selection, and clonogenic assays for hierarchical genomic and regulatory states in neutrophil versus macrophage specification. Nature, 2016 (August 31st)

Click on the links below for article and press release:

Single-cell Analysis of Mixed-Lineage States Leading to a Binary Cell Fate Choice

Publication - "Phototactic Guidance of a Tissue-engineered Soft-Robotic Ray" - Parker Hub Site 17

Dr. Kit Parker and colleagues created a biohybrid system that enables an artificial animal—a tissue-engineered ray—to swim and phototactically follow a light cue. Their work is featured in the July 2016 issue of Science.

Click on the links below to read the full article and press releases:

"Integrated Genomic Analysis of Diverse Induced Pluripotent Stem Cells from the Progenitor Cell Biology Consortium (PCBC)"

Nathan Salomonis, PhD, Carolyn Lutzko, PhD, and colleagues report on the comprehensive characterization of PCBC induced pluripotent stem cells in the June 9th issue of Stem Cell Reports.

“Engineering Hematopoietic Stem Cells: Lessons from Development” (Leonard Zon, George Daley)

In the June 2nd, Cell Stem Cell, Drs. Leonard Zon, George Daley, and colleagues present developmental timing processes in vertebrate hematopoiesis; stage-specific factors specify hematopoietic stem cells (HSC) developmental state required to engineer HSCs for therapy.

Link to full article:

Engineering Hematopoietic Stem Cells: Lessons from Development

Videos Posted from the PCBC Cardiovascular Tissue Engineering (CVTE) Workshop and Symposium

Jay Zhang, M.D., Ph.D., hosted a Cardiovascular Tissue Engineering (CVTE) Workshop and Symposium, on Monday, March 28, 2016, at the University of Alabama in Birmingham. Groups of videos address:

Direct, chemical reprogramming of mouse and human skin cells into cardiac muscle and neural cells – (Srivastava Hub Site 15)

Sheng Ding, PhD, and colleagues’ chemical reprogramming of skin cells into heart cells and brain cells was published recently in Science and Cell Stem Cell.

Click on the links below for articles and press releases:

"Conversion of Human Fibroblasts into Functional Cardiomyocytes by Small Molecules“

Videos Posted from the 2016 Drug Discovery Conference at Stanford University, March 29, 2016 – Wu Hub Site 04

The Stanford Cardiovascular Institute, Wu Hub Site 04, hosted a Cardiovascular Tissue Engineering Symposium and Drug Discovery Conference on March 29, 2016. Experts in drug discovery discussed advances in research and technology.
 

Topics covered included:

Lung Epithelium in Health & Disease Conference _July 31-August 5, 2016

Dr. Carla Kim is organizing a FASEB “Lung Epithelium in Health & Disease” conference.

This conference will take place from July 31- August 5, 2016 in the Horowitz Performing Arts Hall and Nita Choukas Theater, Saxtons River, Vermont.

The deadline for abstract submission is June 26, 2016.

Abstracts from PCBC investigators will be welcome.

Keynote speaker is Dr. Ed Morrisey from Hub Site 14.

What is Good Science: A response to the New Yorker article “The Stress Test”

What is Good Science: A response to the New Yorker article “The Stress Test”

By Lehanna Sanders, Vanderbilt University, Hatzopoulos Hub 11

Illustration by Chad Hagen

Pages

Copyright ©2013 NHLBI Progenitor Cell Biology Consortium.

University of Maryland School of Medicine logo

National Heart Blood and Lung Institute logo