PCBC Stem Cell Training at Stanford University, April 2017

With the support of the NHLBI Progenitor Cell Biology Consortium (PCBC), the Stanford Center for Human Embryonic Stem Cell Research and Education welcomes  both PCBC and PCTC graduate students, fellows, and faculty members to apply for one or both of the following training courses:

"Molecular, Phenotypic, and Sample-associated Data to Describe Pluripotent Stem Cell Lines and Derivatives"

Kenneth Daily, Shannan Sui, Lynn Schriml, and members of the PCBC bioinformatics committee report on the comprehensive characterization and differentiation of 57 pluripotent stem cell lines from 10 laboratories.  

Raw data, metadata, analysis and processing code, and documentation are publicly available at https://www.synapse.org/pcbc.

Click on the link below for full article from Scientific Data:

http://www.nature.com/articles/sdata201730

Publications from Dr. Jay Zhang and colleagues on cardiovascular tissue constructs

Review:

Jay Zhang and colleagues reported on the development and validation of 3D human cardiovascular tissue equivalents. Circulation Research (January 5th, 2017)

Click on the links below to access the review:

From Microscale Devices to 3D Printing: Advances in Fabrication of 3D Cardiovascular Tissues

NHLBI Strategic Visioning

The NHLBI has released "Charting the Future Together: The NHLBI Strategic Vision.”

More details:

https://www.nhlbi.nih.gov/about/documents/strategic-vision

 

 

Endoglin Integrates BMP and Wnt Signalling to Induce Haematopoiesis through JDP2

June Baik, Rita Perlingeiro, James Thomson, and colleagues reported on BMP and Wnt signalling pathways and endoglin in cardiac and haematopoietic lineage specification, in the October 2016 issue of Nature Communications.

Click on the links below to read the full article and press release:

http://www.nature.com/articles/ncomms13101

https://www.sciencedaily.com/releases/2016/10/161007120621.htm

Single-Cell Analysis of Mixed-Lineage States Leading to a Binary Cell Fate Choice – PCBC Bioinformatics Core

Nathan Salomonis, PhD, Bruce Aronow, PhD, and colleagues report on single-cell RNA sequencing, iterative clustering and guide-gene selection, and clonogenic assays for hierarchical genomic and regulatory states in neutrophil versus macrophage specification. Nature, 2016 (August 31st)

Click on the links below for article and press release:

Single-cell Analysis of Mixed-Lineage States Leading to a Binary Cell Fate Choice

Publication - "Phototactic Guidance of a Tissue-engineered Soft-Robotic Ray" - Parker Hub Site 17

Dr. Kit Parker and colleagues created a biohybrid system that enables an artificial animal—a tissue-engineered ray—to swim and phototactically follow a light cue. Their work is featured in the July 2016 issue of Science.

Click on the links below to read the full article and press releases:

"Integrated Genomic Analysis of Diverse Induced Pluripotent Stem Cells from the Progenitor Cell Biology Consortium (PCBC)"

Nathan Salomonis, PhD, Carolyn Lutzko, PhD, and colleagues report on the comprehensive characterization of PCBC induced pluripotent stem cells in the June 9th issue of Stem Cell Reports.

“Engineering Hematopoietic Stem Cells: Lessons from Development” (Leonard Zon, George Daley)

In the June 2nd, Cell Stem Cell, Drs. Leonard Zon, George Daley, and colleagues present developmental timing processes in vertebrate hematopoiesis; stage-specific factors specify hematopoietic stem cells (HSC) developmental state required to engineer HSCs for therapy.

Link to full article:

Engineering Hematopoietic Stem Cells: Lessons from Development

Videos Posted from the PCBC Cardiovascular Tissue Engineering (CVTE) Workshop and Symposium

Jay Zhang, M.D., Ph.D., hosted a Cardiovascular Tissue Engineering (CVTE) Workshop and Symposium, on Monday, March 28, 2016, at the University of Alabama in Birmingham. Groups of videos address:

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