6th Annual PCTC Meeting, March 28-29, 2023

HOLD THE DATE(S)

The 6th Annual PCTC Meeting is scheduled for Tuesday & Wednesday, March 28-29, 2023, on the NIH campus in Bethesda, Maryland. Additional information will be sent out over the next few weeks and months regarding the 6th Annual PCTC Meeting.

Progenitor Cell Biology Consortium (PCBC) Cell Differentiation Data Available for Access

Progenitor Cell Biology Consortium (PCBC) Cell Differentiation Data Available for Access

The Progenitor Cell Biology Consortium (PCBC), is a NHLBI sponsored effort to identify and characterize progenitor cell lineages, to direct the differentiation of stem and progenitor cells to desired cell fates, and to develop new strategies to address the unique challenges presented by the transplantation of these cells.

Progenitor Cell Biology Consortium (PCBC) Stem Cell Collection Available Through WiCell

The Progenitor Cell Biology Consortium (PCBC) of the National Heart, Lung, and Blood Institute (NHLBI) performed comprehensive experimental and genomic analyses of iPSC and hESC lines from different laboratories derived using a variety of reprogramming methods.  Culture systems for the cell lines were harmonized. Resulting data are publicly available through Synapse.  

Publication: Spatial-Temporal Lineage Restrictions of Embryonic p63+ Progenitors Establish Distinct Stem Cell Pools in Adult Airways

Yang and colleagues (Cardoso’s lab) report on how basal cells emerge during development  and how a subset of  these progenitors mediate the pathological alveolar remodeling after influenza injury.

Spatial-Temporal Lineage Restrictions of Embryonic p63+ Progenitors Establish Distinct Stem Cell Pools in Adult Airways

Y. Yang, P. Riccio, M. Schotsaert, M. Mori, J. Lu, D-K. Lee ,A. Garcıa-Sastre, J. Xu, and W.V. Cardoso. Developmental Cell 44, 752–761, March 26, 2018

Link to full article:

“Molecular and Functional Resemblance of Differentiated Cells Derived from Isogenic Human iPSCs and SCNT-derived ESCs”

Joseph Wu, Ming-Tao Zhao, Michael Snyder, Shoukhrat Mitalipov, and colleagues reported that differentiated cells derived from human iPSCs are comparable to nuclear transfer-derived ESC counterparts with regard to transcriptional, epigenetic, physiological, and pharmacological features, given that they are genetically identical. They conclude that human iPSCs are capable of replacing SCNT for generating differentiated cells for drug testing and disease modeling. [07Dec2017 PNAS]

Click on links below to access full article and press release:

Job Opportunity: Postdoctoral Fellow: Massachusetts General Hospital Center for Regenerative Medicine

The Sykes Lab is seeking one postdoctoral fellow to join their team.

The Sykes Lab is focused on myeloid development, and how this process goes awry in the setting of infection or malignancy to develop new treatments for patients with blood disorders, both benign (e.g., neutropenia), and malignant (e.g., leukemia).

Publication: “Synthetic Transcription Elongation Factors License Transcription Across Repressive Chromatin”

Aseem Ansari, Graham Erwin, Matthew Grieshop, and colleagues designed sequence-specific synthetic transcription elongation factors (Syn-TEFs) that convert inhibitors of transcription into gene-specific stimulators.

[30Nov2017 Science]

Click on links below for press release and article:

https://news.wisc.edu/designer-molecule-points-to-treatment-for-diseases-caused-by-dna-repeats/

Publication: “Anatomically and Functionally Distinct Lung Mesenchymal Populations Marked by Lgr5 and Lgr6”

Carla Kim, Joo-Hyeon Lee, Tuomas Tammela, and colleagues reported that heterogeneous mesenchymal cell populations in the lung play a central role in epithelial maintenance and alveolar differentiation. [07Sep2017 Cell]

Click on link below to access full article:

http://www.sciencedirect.com/science/article/pii/S0092867417308644

 

“Overcoming the Roadblocks to Cardiac Cell Therapy Using Tissue Engineering”

Report from the PCBC Cardiovascular Tissue Engineering Symposium, Birmingham, AL, March 2016

Link to full article:

http://www.onlinejacc.org/content/70/6/766

 

 

Postdoctoral Positions – iPS cells and muscle regeneration

Two postdoctoral researcher positions are available in the laboratory of Dr. Rita Perlingeiro at the Lillehei Heart Institute, University of Minnesota, to study skeletal muscle differentiation from pluripotent stem cells (Cell Stem Cell, 10:610, 2012; Nat. Comm. 4:1549, 2013; Cell Reports, 19:2867, 2017). One project is focused on gene editing of patient-specific LGMD2I iPS cells, and the other on the development and optimization of cGMP iPS-derived myogenic progenitors for clinical trial readiness.

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