U01 Principal Investigators

The Progenitor Cell Biology Consortium's lead principal investigators.

members: 
jcooke's picture
John P. Cooke, M.D., Ph.D.
The Houston Methodist Research Institute
iPSC Hematologic and Vascular Therapies
Recent publications:
  • Wong WT, Huang NF, Botham CM, Sayed N, Cooke JP. Endothelial cells derived from nuclear reprogramming. Circ Res. 2012;111:1363-1375
  • Lee J, Sayed N, Hunter A, Au KF, Wong WH, Mocarski ES, Pera RR, Yakubov E, Cooke JP. Activation of innate immunity is required for efficient nuclear reprogramming. Cell. 2012;151:547-558
  • White MP, Rufaihah AJ, Liu L, Ghebremariam YT, Ivey KN, Cooke JP, Srivastava D. Limited gene expression variation in human embryonic stem cell and induced pluripotent stem cell derived endothelial cells. Stem Cells. 2012
  • Lai ES, Huang NF, Cooke JP, Fuller GG. Aligned nanofibrillar collagen regulates endothelial organization and migration. Regenerative medicine. 2012;7:649-661
  • Huang NF, Okogbaa J, Babakhanyan A, Cooke JP. Bioluminescence imaging of stem cell-based therapeutics for vascular regeneration. Theranostics. 2012;2:346-354
  • Volz KS, Miljan E, Khoo A, Cooke JP. Development of pluripotent stem cells for vascular therapy. Vascular pharmacology. 2012;56:288-296
  • Rufaihah AJ, Huang NF, Jame S, Lee JC, Nguyen HN, Byers B, De A, Okogbaa J, Rollins M, Reijo-Pera R, Gambhir SS, Cooke JP. Endothelial cells derived from human iPSCs increase capillary density and improve perfusion in a mouse model of peripheral arterial disease. Arterioscler Thromb Vasc Biol. 2011;31:e72-79
  • Yang WC, Welsh JP, Lee J, Cooke JP, Swartz JR. Solubility partner if2 domain i enables high yield synthesis of transducible transcription factors in escherichia coli. Protein Expr Purif. 2011;80:145-151
  • Chang E, Forsberg EC, Wu J, Bingyin W, Prohaska SS, Allsopp R, Weissman IL, Cooke JP. Cholinergic activation of hematopoietic stem cells: Role in tobacco-related disease? Vasc Med. 2010;15:375-385
  • Leeper NJ, Hunter AL, Cooke JP. Stem cell therapy for vascular regeneration: Adult, embryonic, and induced pluripotent stem cells. Circulation. 2010;122:517-526
  • Huang NF, Patlolla B, Abilez O, Sharma H, Rajadas J, Beygui RE, Zarins CK, Cooke JP. A matrix micropatterning platform for cell localization and stem cell fate determination. Acta Biomater. 2010;6:4614-4621
  • Huang NF, Niiyama H, Peter C, De A, Natkunam Y, Fleissner F, Li Z, Rollins MD, Wu JC, Gambhir SS, Cooke JP. Embryonic stem cell-derived endothelial cells engraft into the ischemic hindlimb and restore perfusion. Arterioscler Thromb Vasc Biol. 2010;30:984-991
  • Huang NF, Fleissner F, Sun J, Cooke JP. Role of nitric oxide signaling in endothelial differentiation of embryonic stem cells. Stem Cells Dev. 2010;19:1617-1626
dgarry's picture
Daniel J. Garry, M.D., Ph.D.
University of Minnesota
Programming and Reprogramming: CV and HSC Fate
Recent publications:
  • Ferdous A, Caprioli A, Iacovino M, Martin CM, Morris J, Richardson JA, Latif S, Hammer RE, Harvey RP, Olson EN, Kyba M, Garry DJ. Nkx2-5 transactivates the Ets-related protein 71 gene and specifies an endothelial/endocardial fate in the developing embryo. Proc Natl Acad Sci USA 2009; 106:814-819. http://www.pnas.org/content/106/3/814.abstract|Abstract
  • Martin CM, Ferdous A, Gallardo T, Humphries C, Sadek H, Caprioli A, Garcia JA, Szweda LI, Garry MG, Garry DJ. Hypoxia-inducible factor-2alpha transactivates Abcg2 and promotes cytoprotection in cardiac side-population cells. Circ Res 2008; 102:1075-1081. http://circres.ahajournals.org/cgi/content/abstract/102/9/1075 Abstract
ahatzopoulos's picture
Antonis K. Hatzopoulos, Ph.D.
Vanderbilt University
Stem Cell Use in Heart Repair
Recent publications:
  • Schulz, H, Kolde, R, Adler, P, Aksoy, I, Anastassiadis, K, Bader, M, Billon, N, Boeuf, H, Bourillot, PY, Buchholz, F, Dani, C, Doss, MX, Forrester, L, Gitton, M, Henrique, D, Hescheler, J, Himmelbauer, H, Hübner, N, Karantzali, E, Kretsovali, A, Lubitz, S, Pradier, L, Rai, M, Reimand, J, Rolletschek, A, Sachinidis, A, Savatier, P, Stewart, F, Storm, MP, Trouillas, M, Vilo, J, Welham, MJ, Winkler, J, Wobus, AM, Hatzopoulos, AK. The FunGenES database: a genomics resource for mouse embryonic stem cell differentiation. PLoS One, 4(9), e6804, 2009. http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0006804
  • Traverse, JH, Henry, TD, Vaughn, DE, Ellis, SG, Pepine, CJ, Willerson, JT, Zhao, DX, Piller, LB, Penn, MS, Byrne, BJ, Perin, EC, Gee, AP, Hatzopoulos, AK, McKenna, DH, Forder, JR, Taylor, DA, Cogle, CR, Olson, RE, Jorgenson, BC, Sayre, SL, Vojvodic, RW, Gordon, DJ, Skarlatos, SI, Moye'', LA, Simari, RD.  Rationale and design for TIME: A phase II, randomized, double-blind, placebo-controlled pilot trial evaluating the safety and effect of timing of administration of bone marrow mononuclear cells after acute myocardial infarction. Am Heart J, 158(3), 356-63, 2009. http://www.ahjonline.com/article/S0002-8703%2809%2900451-7/abstract
mkrasnow's picture
Mark A. Krasnow, M.D., Ph.D.
Stanford University
Progenitor Cells and their Niches
Recent publications:
  • Cell plasticity in lung injury and repair: report from an NHLBI workshop, April 19-20, 2010. Borok Z, Whitsett JA, Bitterman PB, Thannickal VJ, Kotton DN, Reynolds SD, Krasnow MA, Bianchi DW, Morrisey EE, Hogan BL, Kurie JM, Walker DC, Radisky DC, Nishimura SL, Violette SM, Noble PW, Shapiro SD, Blaisdell CJ, Chapman HA, Kiley J, Gail D, Hoshizaki D. Proc Am Thorac Soc. 2011 Jun;8(3):215-22. PMID: 21653526
    http://www.ncbi.nlm.nih.gov/pubmed/21653526
  • Targeting Robo4-dependent Slit signaling to survive the cytokine storm in sepsis and influenza. London NR, Zhu W, Bozza FA, Smith MC, Greif DM, Sorensen LK, Chen L, Kaminoh Y, Chan AC, Passi SF, Day CW, Barnard DL, Zimmerman GA, Krasnow MA, Li DY. Sci Transl Med. 2010 Mar 17;2(23):23ra19. PMID: 20375003
    http://www.ncbi.nlm.nih.gov/pubmed/20375003
  • Coronary arteries form by developmental reprogramming of venous cells. Red-Horse K, Ueno H, Weissman IL, Krasnow MA. Nature. 2010 Mar 25;464(7288):549-53. PMID: 20336138
    http://www.ncbi.nlm.nih.gov/pubmed/20336138
  • Dual origin of tissue-specific progenitor cells in Drosophila tracheal remodeling. Weaver M, Krasnow MA. Science. 2008 Sep 12;321(5895):1496-9. Epub 2008 Jul 31. PMID: 18669822
    http://www.ncbi.nlm.nih.gov/pubmed/18669822
  • Circulating blood cells function as a surveillance system for damaged tissue in Drosophila larvae. Babcock DT, Brock AR, Fish GS, Wang Y, Perrin L, Krasnow MA, Galko MJ. Proc Natl Acad Sci U S A. 2008 Jul 22;105(29):10017-22. Epub 2008 Jul 16. PMID: 18632567
    http://www.ncbi.nlm.nih.gov/pubmed/18632567
emorrisey's picture
Edward E. Morrisey, Ph.D.
University of Pennsylvania
Wnt and Notch Progenitor Expansion
Recent publications:
  • Characterization and in vivo pharmacological rescue of a Wnt2-Gata6 pathway required for cardiac inflow tract development. Tian Y, Yuan L, Goss AM, Wang T, Yang J, Lepore JJ, Zhou D, Schwartz RJ, Patel V, Cohen ED, Morrisey EE. Dev Cell. 2010 Feb 16; 18(2):275-87. Abstract
    Preparing for the first breath: genetic and cellular mechanisms in lung development. Morrisey EE, Hogan BL. Dev Cell. 2010 Jan 19; 18(1):8-23. http://www.cell.com/developmental-cell/abstract/S1534-5807(09)00527-9
  • Evidence for coregulation of myocardial gene expression by MEF2 and NFAT in human heart failure. Putt ME, Hannenhalli S, Lu Y, Haines P, Chandrupatla HR, Morrisey EE, Margulies KB, Cappola TP. Circ Cardiovasc Genet. 2009 Jun; 2(3):212-9. Epub 2009 Mar 31.
    http://circgenetics.ahajournals.org/cgi/content/abstract/2/3/212
  • Cohen, ED, Ihida-Stansbury, K. Lu, MM, Jones, PL, Morrisey, EE. Wnt signaling regulates smooth muscle precursor development in the lung via a tenascin-C/platelet derived growth factor receptor pathway J. Clinical Investigation (2009) 119: 2538-2549.
    http://www.jci.org/articles/view/38079
dsrivastava's picture
Deepak Srivastava, M.D.
Gladstone Institute
iPS Cells in Heart Disease
Recent publications:
  • Cordes KR, Sheehy NT, White M, Berry E, Morton SU, Muth AN, Lee T-H, Miano JM, Ivey KN, Srivastava D. (2009) miR-145 and miR-143 regulate smooth muscle cell fate and plasticity. Nature 460:705–710. Abstract
  • Ieda M, Tsuchihashi T, Ivey KN, Ross RS, Hong T-T, Shaw RM, Srivastava D. (2009) Cardiac fibroblasts regulate myocardial proliferation through beta-1 integrin signaling. Dev. Cell 16:233-244. Abstract
  • Fish JE, Santoro MM, Morton SU, Yu S, Yeh RF, Wythe JD, Ivey KN, Bruneau BG, Stainier DYR, Srivastva D. (2008) miR-126 regulates angiogenic signaling and vascular integrity. Dev. Cell 15:272-284. Abstract
  • Ivey KN, Muth A, Arnold J, King FW, Yeh R-F, Fish JE, HSaio EC, Schwartz RJ, Conklin BR, Bernstein HS, Srivastava D. (2008) MicroRNA regulation of cell lineages in mouse and human embryonic stem cells. Cell Stem Cell 2:219-229. Abstract
  • Zhao Y, Ransom JF, Li A, Vedantham V, von Drehle M, Muth AN, Tsuchihashi T, McManus MT, Schwartz RJ, Srivastava D. (2007) Dysregulation of cardiogenesis, cardiac conduction, and cell cycle in mice lacking miRNA-1-2. Cell 129:303–317. Abstract
btorokst's picture
Beverly Torok-Storb, Ph.D., M.Ed.
Fred Hutchinson Cancer Research Center
ESC Platelet Therapeutics
Recent publications:
  • Long-term regulation of genetically modified primary hematopoietic cells in dogs. Okazuka K, Beard BC, Emery DW, Schwarzwaelder K, Spector MR, Sale GE, von Kalle C, Torok-Storb B, Kiem HP, Blau CA. Mol Ther. 2011 Jul;19(7):1287-94. doi: 10.1038/mt.2011.8. Epub 2011 Feb 15. Erratum in: Mol Ther. 2011 Nov;19(11):2102PMID:21326218 [PubMed - indexed for MEDLINE]
    http://www.ncbi.nlm.nih.gov/pubmed/21326218
  • The role of the marrow microenvironment in hematopoietic stem cell transplantation. Ramakrishnan A, Torok-Storb BJ. Cell Ther Transplant. 2010 Apr 1;2(7):7-12. PMID:21243120[PubMed]
    http://www.ncbi.nlm.nih.gov/pubmed/21243120
  • Pharmacological immunosuppression reduces but does not eliminate the need for total-body irradiation in nonmyeloablative conditioning regimens for hematopoietic cell transplantation. Mielcarek M, Torok-Storb B, Storb R. Biol Blood Marrow Transplant. 2011 Aug;17(8):1255-60. Epub 2011 Jan 8. PMID:21220032[PubMed - in process]
    http://www.ncbi.nlm.nih.gov/pubmed/21220032
  • Mesenchymal stromal cells fail to prevent acute graft-versus-host disease and graft rejection after dog leukocyte antigen-haploidentical bone marrow transplantation. Mielcarek M, Storb R, Georges GE, Golubev L, Nikitine A, Hwang B, Nash RA, Torok-Storb B. Biol Blood Marrow Transplant. 2011 Feb;17(2):214-25. Epub 2010 Oct 30. PMID: 20816818 [PubMed - indexed for MEDLINE]
    http://www.ncbi.nlm.nih.gov/pubmed/20816818
  • Canine bone marrow-derived mesenchymal stromal cells suppress alloreactive lymphocyte proliferation in vitro but fail to enhance engraftment in canine bone marrow transplantation. Lee WS, Suzuki Y, Graves SS, Iwata M, Venkataraman GM, Mielcarek M, Peterson LJ, Ikehara S, Torok-Storb B, Storb R. Biol Blood Marrow Transplant. 2011 Apr;17(4):465-75. Epub 2010 May 10. PMID:20457265[PubMed - indexed for MEDLINE]
    http://www.ncbi.nlm.nih.gov/pubmed/20457265
ibernstein's picture
Irwin D. Bernstein, M.D.
Fred Hutchinson Cancer Research Center
Wnt and Notch Progenitor Expansion
Recent publications:
  • Butler JM, Nolan DJ, Vertes EL, Varnum-Finney B, Kobayashi H, Hooper AT, Seandel M, Shido K, White IA, Kobayashi M, Witte L, May C, Shawber C, Kimura Y, Kitajewski J, Rosenwaks Z, Bernstein ID, Rafii S (2010) Endothelial Cells Are Essential for the Self-Renewal and Repopulation of Notch-Dependent Hematopoietic Stem Cells., Cell Stem Cell, 6 (3), 251-264
    http://www.cell.com/cell-stem-cell/retrieve/pii/S1934590910000457
  • Dallas MH, Varnum-Finney B, Delaney C, Kato K, Bernstein ID (2005) Density of the Notch ligand Delta1 determines generation of B and T cell precursors from hematopoietic stem cells., J Exp Med, 201 (9), 1361-6 http://jem.rupress.org/content/201/9/1361.long
gdaley's picture
George Q. Daley, M.D., Ph.D.
Children's Hospital Boston
iPS and Progenitor Cell Models
Recent publications:
  • Agarwal S, Loh Y-H, McLoughlin EM, Huang J, Park I-H, Miller JD, Huo H, Rosana Okuka M, Maria dos Reis RM, Loewer S, Ng, H-H, Keefe DL, Goldman FD, Klingelhutz AJ, Liu L, Daley GQ. Telomere elongation in dyskeratosis congenita induced pluripotent stem cells. Nature 2010 464(7286):292-6.
    http://www.nature.com/nature/journal/v464/n7286/full/nature08792.html
  • Adamo L, Naveiras O, McKinney-Freeman S, Mack PJ, Suchy-Dicey A, Yoshimoto M, Lensch MW, Yoder MC, #García-Cardeña G, #Daley GQ. Biomechanical forces promote embryonic hematopoiesis. Nature 2009 Jun 25; 459(7250):1131-5. Epub 2009 May 13. *equal contribution/ #co-corresponding authors.
    http://www.nature.com/nature/journal/v459/n7250/full/nature08073.html
afriedman's picture
Alan D. Friedman, M.D.
Johns Hopkins University
iPSC Hematologic and Vascular Therapies
Recent publications:
  • Paz-Priel I, Houng S, Dooher J, Friedman AD. (2011). C/EBPα and C/EBPα oncoproteins regulate nfkb1 and displace histone deacetylases from NF- κB p50 homodimers to induce expression of NF-κB target genes. Blood; in press. http://www.ncbi.nlm.nih.gov/pubmed/21346255
  • Paz-Priel I., Ghosal A.K, Kowalski J., and Friedman A.D. (2009). C/EBPa or C/EBPa oncoproteins regulate the intrinsic and extrinsic apoptotic pathways by direct interaction with NF-kB p50 bound to the bcl-2 and FLIP gene promoters. Leukemia 23:365-74.
    http://www.nature.com/leu/journal/v23/n2/abs/leu2008297a.html
  • Cai D.H., Wang D., Keefer J., Yeamans C., Hensley K., and Friedman A.D. (2008). C/EBPa:AP-1 leucine zipper heterodimers bind novel DNA element, activate the PU.1 promoter, and direct monocyte lineage commitment more potently Than C/EBPa homodimers or AP-1. Oncogene 27:2772-9.
    http://www.nature.com/onc/journal/v27/n19/full/1210940a.html
mponcz's picture
Mortimer Poncz, M.D.
Children's Hospital of Philadelphia
ESC Platelet Therapeutics
Recent publications:

  • 120) Gregory GD, Miccio A, Bersenev A, Wang Y, Hong W, Zhang Z, Poncz M, Tong W, Blobel GA. FOG1 requires NuRD to promote hematopoiesis and maintain lineage fidelity within the megakaryocytic-erythroid compartment. Blood 2010;115:2156-66.[PMID 20065294]

  • 121) Zaitzev S, Spitzer D, Murciano JC, Ding BS, Tliba S, Kowalska MA, Bdeir K, Kuo A, Stepanova V, Atkinson JP, Poncz M, Cines DB, Muzykantov VR. Targeting of a mutant plasminogen activator to circulating red blood cells for prophylactic fibrinolysis. J Pharmacol Exp Ther 2010;332:1022-31. [PMID19952305]

  • 122) Miccio A, Wang Y, Hong W, Gregory GD, Wang H, Yu X, Choi JK, Shelat S, Tong W, Poncz M, Blobel GA. NuRD mediates activating and repressive functions of GATA-1 and FOG-1 during blood development. EMBO J 2010;29:442-56. [PMID19927129]

  • 123) Rauova L, Hirsch JD, Greene TK, Zhai L, Hayes VM, Kowalska MA, Cines DB, Poncz M. Monocyte-bound PF4 in the pathogenesis of heparin-induced thrombocytopenia. Blood 2010;116:5021-31. [PMID20724543]

  • 124) Mei J, Liu Y, Dai N, Favara M, Greene T, Jeyaseelan S, Poncz M, Lee JS, Worthen GS. CXCL5 regulates chemokine scavenging and pulmonary host defense to bacterial infection. Immunity 2010;33:106-17. [PMID20643340]

  • 125) Fuentes R, Wang Y, Hirsch J, Wang C, Rauova L, Worthen GS, Kowalska MA, Poncz M. Infusion of mature megakaryocytes into mice yields functional platelets. J Clin Invest 2010;120:3917-22. [PMC2964983]

  • 126) Greene TK, Wang C, Hirsch JD, Zhai L, Gewirtz J, Thornton MA, Miao HZ, Pipe SW, Kaufman RJ, Camire RM, Arruda VR, Kowalska MA, Poncz. In vivo efficacy of platelet-delivered, high specific activity factor VIII. Blood 2010;116:6114-22 [20852129].

  • 127) Zaitsev S, Spitzer D, Murciano JC, Ding BS, Tliba S, Kowalska MA, Marcos-Contreras OA, Kuo A, Stepanova V, Atkinson JP, Poncz M, Cines DB, Muzykantov VR. Sustained thromboprophylaxis mediated by an RBC-targeted pro-urokinase zymogen activated at the site of clot formation. J Pharmacol Exp Ther 2010;332:1022-31. [PMC2835436]

  • 128) Mei J, Liu Y, Dai N, Favara M, Greene T, Jeyaseelan S, Poncz M, Lee JS, Worthen GS. CXCL5 regulates chemokine scavenging and pulmonary host defense to bacterial infection. Immunity 2010;33:106-17. [PMID20643340]

  • 129) Rauova L, Hirsch JD, Greene TK, Zhai L, Hayes VM, Kowalska MA, Cines DB, Poncz M. Monocyte-bound PF4 in the pathogenesis of heparin-induced thrombocytopenia. Blood 2010;11623:5021-31. [PMID20724543]

  • 130) Stolla M, Stefanini L, Roden RC, Chavez M, Hirsch J, Greene T, Ouellette TD, Maloney SF, Diamond SL, Poncz M, Woulfe DS, Bergmeier W. The kinetics of {alpha}IIb{beta}3 activation determines the size and stability of thrombi in mice: implications for antiplatelet therapy. Blood 2011;117:1005-13. [PMID20971951]
jschneider's picture
Jay W. Schneider, M.D., Ph.D.
UT Southwestern Medical Center
Microenvironmental Control of Progenitors
Recent publications:
  • Targeting Native Adult Heart Progenitors with Cardiogenic Small Molecules. Russell JL, Goetsch SC, Aguilar HR, Frantz DE, Schneider JW. ACS Chem Biol. 2012 Apr 13. [Epub ahead of print] PMID: 22413910 http://www.ncbi.nlm.nih.gov/pubmed/22413910
  • A small molecule differentiation inducer increases insulin production by pancreatic β cells. Dioum EM, Osborne JK, Goetsch S, Russell J, Schneider JW, Cobb MH. Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20713-8. Epub 2011 Dec 5. PMID: 22143803
    http://www.ncbi.nlm.nih.gov/pubmed/22143803
  • Small-molecule blocks malignant astrocyte proliferation and induces neuronal gene expression. Zhang L, Li P, Hsu T, Aguilar HR, Frantz DE, Schneider JW, Bachoo RM, Hsieh J. Differentiation. 2011 Apr;81(4):233-42. Epub 2011 Mar 17. PMID: 21419563
    http://www.ncbi.nlm.nih.gov/pubmed/21419563
  • A dynamic notch injury response activates epicardium and contributes to fibrosis repair. Russell JL, Goetsch SC, Gaiano NR, Hill JA, Olson EN, Schneider JW. Circ Res. 2011 Jan 7;108(1):51-9. Epub 2010 Nov 24. PMID: 21106942
    http://www.ncbi.nlm.nih.gov/pubmed/21106942
  • The distinct metabolic profile of hematopoietic stem cells reflects their location in a hypoxic niche. Simsek T, Kocabas F, Zheng J, Deberardinis RJ, Mahmoud AI, Olson EN, Schneider JW, Zhang CC, Sadek HA. Cell Stem Cell. 2010 Sep 3;7(3):380-90. PMID: 20804973
    http://www.ncbi.nlm.nih.gov/pubmed/20804973
jthomson's picture
James A. Thomson, M.D., Ph.D.
University of Wisconsin
Programming and Reprogramming: CV and HSC Fate
Recent publications:
  • Chen G, Hou Z, Gulbranson D, Thomson JA. "Actin-myosin contractility is responsible for the reduced viability of dissociated human embryonic stem cells." Cell Stem Cell (2010). 7(2): 240-248.
  • Lister R, Pelizzola M, Kida YS, Hawkins RD, Nery JR, Hon G, Antosiewicz-Bourget J, O’Malley R, Castanon R, Downes M, Yu R, Stewart R, Ren B, Thomson JA, Evans RM,Ecker JR. “Hotspots of aberrant epigenomic reprogramming in human iPS cells.” Nature, (2011): 471(7336): 68-73.
  • Yu P, Pan G, Yu J, Thomson JA. “FGF2 sustains NANOG and switches BMP4 induced human ES cell differentiation from trophoblast to mesendoderm.” Cell Stem Cell (2011): 8(6): 326-334.
  • Chen G, Gulbranson D, Hou Z, Bolin J, Probasco MD, Smuga-Otto K, Howden S, Diol N, Propson NE, Wagner R, Lee GO, Antosiewicz-Bourget J, Teng JMC, Thomson JA. “Chemically defined conditions for human iPS cell derivation and culture.” Nature Methods (2011): 8(5):424-9.
  • Howden SE, Gore A, Li Zhe, Fung H, Nisler BS, Nie J, Chen G, McIntosh BE, Gulbranson DR, Diol NR, Taapken SM, Vereide DT, Montgomery KD, Zhang K, Gamm D, Thomson JA. “Genetic correction and analysis of induced pluripotent stem cells from a patient with gyrate atrophy.” Proc Natl Acad Sci USA, Epub 4 Apr (2011).
iweissman's picture
Irving Weissman, M.D.
Stanford University
Progenitor Cells and their Niches
Recent publications:
  • Antibody therapy targeting the CD47 protein is effective in a model of aggressive metastatic leiomyosarcoma. Edris B, Weiskopf K, Volkmer AK, Volkmer JP, Willingham SB, Contreras-Trujillo H, Liu J, Majeti R, West RB, Fletcher JA, Beck AH, Weissman IL, van de Rijn M. Proc Natl Acad Sci U S A. 2012 http://www.ncbi.nlm.nih.gov/pubmed/22451919?dopt=Abstract&otool=stanford
  • Long-term outcome of patients with metastatic breast cancer treated with high-dose chemotherapy and transplantation of purified autologous hematopoietic stem cells. Müller AM, Kohrt HE, Cha S, Laport G, Klein J, Guardino AE, Johnston LJ, Stockerl-Goldstein KE, Hanania E, Juttner C, Blume KG, Negrin RS, Weissman IL, Shizuru JA. Biol Blood Marrow Transplant. 2012; 18 (1): 125-33 http://www.ncbi.nlm.nih.gov/pubmed/21767515?dopt=Abstract&otool=stanford
  • Three differentiation states risk-stratify bladder cancer into distinct subtypes. Volkmer JP, Sahoo D, Chin RK, Ho PL, Tang C, Kurtova AV, Willingham SB, Pazhanisamy SK, Contreras-Trujillo H, Storm TA, Lotan Y, Beck AH, Chung BI, Alizadeh AA, Godoy G, Lerner SP, van de Rijn M, Shortliffe LD, Weissman IL, Chan KS. Proc Natl Acad Sci U S A. 2012 http://www.ncbi.nlm.nih.gov/pubmed/22308455?dopt=Abstract&otool=stanford
joewu's picture
Joseph Wu, M.D., Ph.D.
Stanford-Gladstone
iPS Cells in Heart Disease
Recent publications:

 

  • Patient-specific induced pluripotent stem cells as a model for familial dilated cardiomyopathy.Sun N, Yazawa M, Liu J, Han L, Sanchez-Freire V, Abilez OJ, Navarrete EG, Hu S, Wang L, Lee A, Pavlovic A, Lin S, Chen R, Hajjar RJ, Snyder MP, Dolmetsch RE, Butte MJ, Ashley EA, Longaker MT, Robbins RC, Wu JC. Sci Transl Med. 2012; 4 (130): 130ra47 Abstract
  • Production of de novo cardiomyocytes: human pluripotent stem cell differentiation and direct reprogramming. Burridge PW, Keller G, Gold JD, Wu JC. Cell Stem Cell. 2012; 10 (1): 16-28 Abstract
  • An antibody against SSEA-5 glycan on human pluripotent stem cells enables removal of teratoma-forming cells. Tang C, Lee AS, Volkmer JP, Sahoo D, Nag D, Mosley AR, Inlay MA, Ardehali R, Chavez SL, Pera RR, Behr B, Wu JC, Weissman IL, Drukker M. Nat Biotechnol. 2011; 29 (9): 829-34 Abstract
  • Short-term immunosuppression promotes engraftment of embryonic and induced pluripotent stem cells. Pearl JI, Lee AS, Leveson-Gower DB, Sun N, Ghosh Z, Lan F, Ransohoff J, Negrin RS, Davis MM, Wu JC. Cell Stem Cell. 2011; 8 (3): 309-17 Abstract 
  • Single cell transcriptional profiling reveals heterogeneity of human induced pluripotent stem cells. Narsinh KH, Sun N, Sanchez-Freire V, Lee AS, Almeida P, Hu S, Jan T, Wilson KD, Leong D, Rosenberg J, Yao M, Robbins RC, Wu JC. J Clin Invest. 2011; 121 (3): 1217-21 Abstract

 

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