Synthetic Genome Readers Target Clustered Binding Sites Across Diverse Chromatin States

posted by sitemanager on Mon, 12/05/2016 - 10:11am
Hub Site: 
02-James Thomson
Author(s): 
Graham S. Erwina, Matthew P. Grieshopa,1, Devesh Bhimsariaa,b,1, Truman J. Doa, José A. Rodríguez-Martíneza, Charu Mehtaa, Kanika Khannaa, Scott A. Swansonc, Ron Stewartc, James A. Thomsonc,d, Parameswaran Ramanathanb, and Aseem Z. Ansaria,d,2
Publication Type: 
Original Research Article
Name of Journal, Book, etc.: 
PNAS
Year: 
2016
PMID Reference: 
Synthetic Genome Readers Target Clustered Binding Sites Across Diverse Chromatin States

Dr. Aseem Ansari and colleagues in the Midwest PCBC Research Hub, reported that designer DNA-binding small molecules can associate with specific sites in repressive heterochromatin of human embryonic stem cells.

Click on the links below for article and press release:

http://www.pnas.org/content/early/2016/11/07/1604847113.long

http://news.wisc.edu/first-cellular-atlas-of-dna-binding-molecule-could-advance-precision-therapies/

 

 

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