The RNAcore at the Houston Methodist Research Institute is staffed by experienced scientists and technicians, who produce high-fidelity research and clinical-grade RNA, including mRNA, modified mRNA (mmRNA), and noncoding RNA, for the support of fundamental research and clinical applications.

The RNAcore is emerging as a leader in RNA synthesis, generating RNA constructs for the scientific and medical communities in the Texas Medical Center and across the world. Beginning as a core group for the Progenitor Cell Biology Consortium of the National Heart, Lung, and Blood Institute, the RNAcore is now also supported in part by the Cancer Prevention Research Institute of Texas, to further the development of cutting edge RNA technologies.

The RNAcore provides services for the development and generation of high-fidelity RNA for any gene/loci of interest. With the use of an error-free plasmid template and efficient, fast construct generation, we can provide a wide range of generic or personalized RNA molecules for any desired species, with specified modifications.

Synthesis of high-fidelity research- and clinical-grade RNA, including:

  • mRNA
  • Modified mRNA (mmRNA)
  • Customized bicistronic constructs
  • Constructs with reporter genes
  • Long noncoding RNA

Incorporation of RNA modifications in molecules:

  • 5-methyl-CTP
  • Pseudo-UTP
  • Anti-reverse cap analog (ARCA)
  • Long 150 nt poly-A tail
  • Sequence-optimized

Generation of RNA molecules using the following methods:

  • Research-grade, without HPLC
  • Research-grade, with HPLC
  • cGMP-grade

To learn more, click on the link below:

http://www.houstonmethodist.org/research/our-research/cores/rnacore/ or contact the RNAcore at rnacore@houstonmethodist.org.



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