HS16 - Garry Hub Site

Dr. Garry’s laboratory has a long-standing interest in regenerative and stem cell biology with a focus on the heart and skeletal muscle. In their studies of the heart and skeletal muscle, the laboratory utilizes an array of technologies including gene disruption strategies, transgenesis, single cell genome analysis, gene editing (TALEN and CRISPR technologies), inducible ES/EB model systems, hiPSC technologies, FACS and other cellular, biochemical and molecular biological techniques.  In addition, their use of lower organisms such as zebrafish and newt, which are highly regenerative model systems have successfully uncovered critical regenerative factors.  Human iPSCs are another important model for cardiovascular disease investigation for the lab.  Using these technologies, the Garry lab was among the first to discover the molecular markers of stem cell populations that regulate critical networks during heart and skeletal muscle development and regeneration.  For example, their studies have uncovered novel Ets and Forkhead transcription factors, microRNAs and signaling pathways that direct fate determination of stem cell populations.  The manipulation of these pathways using chemical genetics and molecular technologies has provided a platform focused on rebuilding and repairing the injured heart and skeletal muscle.

Protocols and Reagents that are associated with this hub site can be accessed by logging into Synapse and searching the database from the appropriate list of protocols or reagents.  Click here for instructions to access Synapse.

Lead Principal Investigator
User Name Full Name Institutional Affilication
dgarry's picture
dgarry Daniel J. Garry, M.D., Ph.D. University of Minnesota
Principal Investigator
User Name Full Name Institutional Affilication
jmetzger's picture
jmetzger Joseph Metzger, Ph.D. University of Minnesota
User Name Full Name Institutional Affilication
jzhang's picture
jzhang Jianyi (Jay) Zhang, M.D., Ph.D. University of Minnesota
rperlingeiro's picture
rperlingeiro Rita Perlingeiro, Ph.D. U Minn
Post-Doctoral Fellow/Trainee
User Name Full Name Institutional Affilication
schan's picture
schan Sunny Chan University of Minnesota
maxxx498's picture
maxxx498 Chao Ma UMN
sdas's picture
sdas Satyabrata Das, Ph.D. Lillehei Heart Institute
jiafei's picture
jiafei Jiafei Xi University of Minnesota
amagli's picture
amagli Alessandro Magli Lillehei Heart Institute
trasmussen's picture
trasmussen Tara Rasmussen University of Minnesota


Author(s) Title Link
Filareto, Antonio; Parker, Sarah; Darabi, Radbod; Borges, Luciene; Iacovino, Michelina; Schaaf, Tory; Mayerhofer, Timothy; Chamberlain, Jeffrey S; Ervasti, James M; McIvor, R Scott; Kyba, Michael; Perlingeiro, Rita C R An ex vivo gene therapy approach to treat muscular dystrophy using inducible pluripotent stem cells view
Behrens, Ann N; Iacovino, Michelina; Lohr, Jamie L; Ren, Yi; Zierold, Claudia; Harvey, Richard P; Kyba, Michael; Garry, Daniel J; Martin, Cindy M Nkx2-5 Mediates Differential Cardiac Differentiation Through Interaction with Hoxa10 view
Xiong, Qiang; Ye, Lei; Zhang, Pengyuan; Lepley, Michael; Tian, Jinfeng; Li, Jun; Zhang, Liying; Swingen, Cory; Vaughan, J Thomas; Kaufman, Dan S; Zhang, Jianyi Functional consequences of human induced pluripotent stem cell therapy: myocardial ATP turnover rate in the in vivo Swine heart with postinfarction remodeling view
Ye, Lei; Zhang, Sophia; Greder, Lucas; Dutton, James; Keirstead, Susan A; Lepley, Mike; Zhang, Liying; Kaufman, Dan; Zhang, Jianyi Effective cardiac myocyte differentiation of human induced pluripotent stem cells requires VEGF view
Kyba, Michael Hemogenic endothelium in a dish view
Sajini, Abdulrahim A; Greder, Lucas V; Dutton, James R; Slack, Jonathan M W Loss of Oct4 expression during the development of murine embryoid bodies view
Kamdar, Forum; Jameel, Mohammad Nurulqadr; Score, Paul; Zhang, Jianyi Cellular therapy promotes endogenous stem cell repair view
Baik, June; Borges, Luciene; Magli, Alessandro; Thatava, Tayaramma; Perlingeiro, Rita C R Effect of endoglin overexpression during embryoid body development view
Xiong, Qiang; Ye, Lei; Zhang, Pengyuan; Lepley, Michael; Swingen, Cory; Zhang, Liying; Kaufman, Dan S; Zhang, Jianyi Bioenergetic and functional consequences of cellular therapy: activation of endogenous cardiovascular progenitor cells view
Koyano-Nakagawa, Naoko; Kweon, Junghun; Iacovino, Michelina; Shi, Xiaozhong; Rasmussen, Tara L; Borges, Luciene; Zirbes, Katie M; Li, Tongbin; Perlingeiro, Rita C R; Kyba, Michael; Garry, Daniel J Etv2 is expressed in the yolk sac hematopoietic and endothelial progenitors and regulates Lmo2 gene expression view


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