HS15 - Srivastava Hub Site

Our laboratory focuses on the fundamental events involved in cell fate determination and differentiation and organogenesis. Specifically, we investigate the molecular events regulating developmental decisions that instruct cardiac progenitor cells to adopt a cardiac cell fate and subsequently fashion a functioning heart. We focus on transcriptional and post-transcriptional steps, including those involving microRNAs. We have leveraged this knowledge to reprogram fibroblasts directly into cardiomyocyte-like cells for regenerative purposes. We also investigate the causes of human cardiovascular disease by applying modern genetic technologies for the study of complex traits such as congenital heart disease. By using fly, mouse, and human genetics, we hope to develop a broad understanding of the biology underlying cardiogenesis and cardiovascular disorders.

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Lead Principal Investigator
User Name Full Name Institutional Affilication
dsrivastava's picture
dsrivastava Deepak Srivastava, M.D. Gladstone Institute
Post-Doctoral Fellow/Trainee
User Name Full Name Institutional Affilication
kcordes's picture
kcordes Kim Cordes, Ph.D. Gladstone Institute
tamer.mohamed's picture
tamer.mohamed Tamer Mohamed Gladstone Institutes
kivey's picture
kivey Kathy Ivey Gladstone Institutes
yensin.ang's picture
yensin.ang Yen-Sin Ang Gladstone Institutes
theodoris's picture
theodoris Christina Theodoris Gladstone Institutes
cgifford's picture
cgifford Casey Gifford, Ph.D. Gladstone Institutes
Emily.Berry's picture
Emily.Berry Emily Berry Gladstone Institutes
jfu's picture
jfu Jidong Fu The J. David Gladstone Institute
palmer.yu's picture
palmer.yu Pengzhi Yu Gladstone Institutes


Author(s) Title Link
White, Mark P; Rufaihah, Abdul J; Liu, Lei; Ghebremariam, Yohannes T; Ivey, Kathryn N; Cooke, John P; Srivastava, Deepak Limited gene expression variation in human embryonic stem cell and induced pluripotent stem cellderived endothelial cells view
Rentschler, Stacey; Epstein, Jonathan A Kicking the epicardium up a notch view
Vedantham, Vasanth; Evangelista, Melissa; Huang, Yu; Srivastava, Deepak Spatiotemporal regulation of an Hcn4 enhancer defines a role for Mef2c and HDACs in cardiac electrical patterning view
Gaborit, Nathalie; Sakuma, Rui; Wylie, John N; Kim, Kyoung-Han; Zhang, Shan- Shan; Hui, Chi-Chung; Bruneau, Benoit G Cooperative and antagonistic roles for Irx3 and Irx5 in cardiac morphogenesis and postnatal physiology view
Hassel, David; Cheng, Paul; White, Mark P; Ivey, Kathryn N; Kroll, Jens; Augustin, Hellmut G; Katus, Hugo A; Stainier, Didier Y R; Srivastava, Deepak MicroRNA-10 regulates the angiogenic behavior of zebrafish and human endothelial cells by promoting vascular endothelial growth factor signaling view
Srivastava, Deepak; Ieda, Masaki; Fu, Jidong; Qian, Li Cardiac repair with thymosin ýý4 and cardiac reprogramming factors view
Wamstad, Joseph A; Alexander, Jeffrey M; Truty, Rebecca M; Shrikumar, Avanti; Li, Fugen; Eilertson, Kirsten E; Ding, Huiming; Wylie, John N; Pico, Alexander R; Capra, John A; Erwin, Genevieve; Kattman, Steven J; Keller, Gordon M; Srivastava, Deepak; Levine, Stuart S; Pollard, Katherine S; Holloway, Alisha K; Boyer, Laurie A; Bruneau, Benoit G Dynamic and coordinated epigenetic regulation of developmental transitions in the cardiac lineage view
Tomoda, Kiichiro; Takahashi, Kazutoshi; Leung, Karen; Okada, Aki; Narita, Megumi; Yamada, N Alice; Eilertson, Kirsten E; Tsang, Peter; Baba, Shiro; White, Mark P; Sami, Salma; Srivastava, Deepak; Conklin, Bruce R; Panning, Barbara; Yamanaka, Shinya Derivation conditions impact X-inactivation status in female human induced pluripotent stem cells view
Srivastava, Deepak; Ieda, Masaki Critical factors for cardiac reprogramming view
Kwon, Chulan; Cheng, Paul; King, Isabelle N; Andersen, Peter; Shenje, Lincoln; Nigam, Vishal; Srivastava, Deepak Notch posttranslationally regulates ýý-catenin protein in stem and progenitor cells view


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