HS13 - Scadden Hub Site

The Scadden lab focuses on blood, particularly the regulation of the hematopoietic stem cell by its microenvironment or niche. Using a combination of genetically modified mice, imaging and pharmacology, the laboratory has defined key components of the niche and how stem cells traffic to and engraft the bone marrow. It has demonstrated methods of altering niche interactions that have resulted in two clinical trials in the use of stem cells to treat hematologic malignancies.

Based on understanding mechanisms by which normal stem cells are governed in normal tissues, the laboratory has emphasized the role of the niche in disease. We have demonstrated the primary role the microenvironment can play in disordered tissue homeostasis and the emergence of malignancy.  Further, we have assessed how regulatory programs controlling normal stem cells are altered in the context of malignancy and we are currently examining in vivo competition between normal and malignant cells.  Our goal is to use these insights to inform novel approaches to blood disorders and cancer.

Protocols and Reagents that are associated with this hub site can be accessed by logging into Synapse and searching the database from the appropriate list of protocols or reagents.  Click here for instructions to access Synapse.

members: 
Co-PI/Co-Investigator
User Name Full Name Institutional Affilication
jrajagopal's picture
jrajagopal Jay Rajagopal, Ph.D. Harvard Stem Cell Institute
aditadi's picture
aditadi Andrea Ditadi McEwen Centr for Regenerative Medicine
awagers's picture
awagers Amy Wagers Harvard University
ckim's picture
ckim Carla F. Kim, Ph.D. Children's Hospital Boston
srandell's picture
srandell Scott Randell, Ph.D. University of North Carolina
clin's picture
clin Charles Lin, Ph.D. Massachusetts General Hospital
Post-Doctoral Fellow/Trainee
User Name Full Name Institutional Affilication
jmahoney's picture
jmahoney John E. Mahoney, Ph.D. Boston Children's Hospital
yjang's picture
yjang Young C. Jang Harvard Stem Cell Institute
jspencer's picture
jspencer Joel Spencer Harvard University
dlee's picture
dlee Dongjun Lee Massachusetts General Hospital

Pages

Publication: 
Author(s) Title Link
Roccaro, Aldo M; Sacco, Antonio; Maiso, Patricia; Azab, Abdel Kareem; Tai, Yu- Tzu; Reagan, Michaela; Azab, Feda; Flores, Ludmila M; Campigotto, Federico; Weller, Edie; Anderson, Kenneth C; Scadden, David T; Ghobrial, Irene M BM mesenchymal stromal cell-derived exosomes facilitate multiple myeloma progression view
Hoggatt, Jonathan; Mohammad, Khalid S; Singh, Pratibha; Hoggatt, Amber F; Chitteti, Brahmananda R; Speth, Jennifer M; Hu, Peirong; Poteat, Bradley A; Stilger, Kayla N; Ferraro, Francesca; Silberstein, Lev; Wong, Frankie K; Farag, Sherif S; Czader, Magdalena; Milne, Ginger L; Breyer, Richard M; Serezani, Carlos H; Scadden, David T; Guise, Theresa A; Srour, Edward F; Pelus, Louis M Differential stem- and progenitor-cell trafficking by prostaglandin E2 view
Lee, Joo-Hyeon; Kim, Jonghwan; Gludish, David; Roach, Rebecca R; Saunders, Arven H; Barrios, Juliana; Woo, Andrew Jonghan; Chen, Huaiyong; Conner, David A; Fujiwara, Yuko; Stripp, Barry R; Kim, Carla F Surfactant protein-C chromatin-bound green fluorescence protein reporter mice reveal heterogeneity of surfactant protein C-expressing lung cells view
Fulzele, Keertik; Krause, Daniela S; Panaroni, Cristina; Saini, Vaibhav; Barry, Kevin J; Liu, Xiaolong; Lotinun, Sutada; Baron, Roland; Bonewald, Lynda; Feng, Jian Q; Chen, Min; Weinstein, Lee S; Wu, Joy Y; Kronenberg, Henry M; Scadden, David T; Divieti Pajevic, Paola Myelopoiesis is regulated by osteocytes through Gsýý-dependent signaling view
Brown, Katharine; Xie, Stephanie; Qiu, Xiaolei; Mohrin, Mary; Shin, Jiyung; Liu, Yufei; Zhang, Dan; Scadden, David T; Chen, Danica SIRT3 reverses agingassociated degeneration view
Yildirim, Eda; Kirby, James E; Brown, Diane E; Mercier, Francois E; Sadreyev, Ruslan I; Scadden, David T; Lee, Jeannie T Xist RNA is a potent suppressor of hematologic cancer in mice view
Krause, Daniela S; Scadden, David T; Preffer, Frederic I The hematopoietic stem cell niche--home for friend and foe? view
Yusuf, Rushdia Zareen; Scadden, David T Fate through fat: lipid metabolism determines stem cell division outcome view
Castano, Zafira; Fillmore, Christine M; Kim, Carla F; McAllister, Sandra S The bed and the bugs: interactions between the tumor microenvironment and cancer stem cells view
Chen, Huaiyong; Matsumoto, Keitaro; Brockway, Brian L; Rackley, Craig R; Liang, Jiurong; Lee, Joo-Hyeon; Jiang, Dianhua; Noble, Paul W; Randell, Scott H; Kim, Carla F; Stripp, Barry R Airway epithelial progenitors are region specific and show differential responses to bleomycin-induced lung injury view

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