HS11 - Hatzopoulos Hub Site

Our research focuses on cardiovascular progenitor cells as a model system to study heart and blood vessel development and as cell therapy tools in adult disease models. We have shown that in vitro expanded embryonic endothelial progenitor cells form blood vessels after transplantation in the developing embryo. In adult disease models, we found that vascular progenitor cells are originally recruited to sites of angiogenesis by endothelial P-selectin. In mouse models of multiple tumors, we demonstrated that the progenitor cells home to hypoxic metastases with high VEGF expression, but spare well-vascularized tumors and normal organs. Based on these findings, we used the cells as “Trojan horses” to deliver toxic agents directly to the tumor tissue killing malignant cells and blocking tumor growth. Exploring further the specific accumulation of progenitor cells to ischemic sites in vivo, we found that transplantation of progenitor cells under acute (heart) or chronic ischemia (hindlimb) enhances vascularization and improves tissue recovery.

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Lead Principal Investigator
User Name Full Name Institutional Affilication
ahatzopoulos's picture
ahatzopoulos Antonis K. Hatzopoulos, Ph.D. Vanderbilt University
User Name Full Name Institutional Affilication
chong's picture
chong Charles C. Hong, M.D., Ph.D. Vanderbilt University
Post-Doctoral Fellow/Trainee
User Name Full Name Institutional Affilication
charmelink's picture
charmelink Cristina Harmelink, PhD Vanderbilt University
dpaik's picture
dpaik David T. Paik Vanderbilt University
tanwar's picture
tanwar Vineeta Tanwar, Ph.D. Vanderbilt University
hsmith's picture
hsmith Holly Smith Vanderbilt University
ychun's picture
ychun Young Wook Chun, Ph.D. Vanderbilt University
jbylund's picture
jbylund Jeffery Bylund Vanderbilt University
lsjean's picture
lsjean Leshana Saint-Jean Vanderbilt University
paige's picture
paige Paige DeBenedittis, Ph.D. Vanderbilt University


Author(s) Title Link
Hill, Michael F; Patel, Amish V; Murphy, Abigail; Smith, Holly M; Galindo, Cristi L; Pentassuglia, Laura; Peng, Xuyang; Lenneman, Carrie G; Odiete, Oghenerukevwe; Friedman, David B; Kronenberg, Marvin W; Zheng, Siyuen; Zhao, Zhongming; Song, Yanna; Harrell Jr, Frank E; Srinivas, Maya; Ganguly, Anindita; Iaci, Jennifer; Parry, Tom J; Caggiano, Anthony O; Sawyer, Douglas B Intravenous glial growth factor 2 (GGF2) isoform of neuregulin-1ýý improves left ventricular function, gene and protein expression in rats after myocardial infarction view
Wu, Bingruo; Zhang, Zheng; Lui, Wendy; Chen, Xiangjian; Wang, Yidong; Chamberlain, Alyssa A; Moreno-Rodriguez, Ricardo A; Markwald, Roger R; O'Rourke, Brian P; Sharp, David J; Zheng, Deyou; Lenz, Jack; Baldwin, H Scott; Chang, Ching-Pin; Zhou, Bin Endocardial cells form the coronary arteries by angiogenesis through myocardial-endocardial VEGF signaling view
Neely, M Diana; Litt, Michael J; Tidball, Andrew M; Li, Gary G; Aboud, Asad A; Hopkins, Corey R; Chamberlin, Reed; Hong, Charles C; Ess, Kevin C; Bowman, Aaron B DMH1, a highly selective small molecule BMP inhibitor promotes neurogenesis of hiPSCs: comparison of PAX6 and SOX1 expression during neural induction view
Rai, Meena; Walthall, Joel M; Hu, Jianyong; Hatzopoulos, Antonis K Continuous antagonism by Dkk1 counter activates canonical Wnt signaling and promotes cardiomyocyte differentiation of embryonic stem cells view
Ni, Terri T; Rellinger, Eric J; Mukherjee, Amrita; Xie, Shuying; Stephens, Lauren; Thorne, Curtis A; Kim, Kwangho; Hu, Jiangyong; Lee, Ethan; Marnett, Larry; Hatzopoulos, Antonis K; Zhong, Tao P Discovering small molecules that promote cardiomyocyte generation by modulating Wnt signaling view
Ikonomou, Laertis; Hemnes, Anna R; Bilousova, Ganna; Hamid, Rizwan; Loyd, James E; Hatzopoulos, Antonis K; Kotton, Darrell N; Majka, Susan M; Austin, Eric D Programmatic change: lung disease research in the era of induced pluripotency view
Melville, David B; Montero- Balaguer, Mercedes; Levic, Daniel S; Bradley, Kevin; Smith, Jeffrey R; Hatzopoulos, Antonis K; Knapik, Ela W The feelgood mutation in zebrafish dysregulates COPII-dependent secretion of select extracellular matrix proteins in skeletal morphogenesis view
Hao, Jijun; Sawyer, Douglas B; Hatzopoulos, Antonis K; Hong, Charles C Recent Progress on Chemical Biology of Pluripotent Stem Cell Self-renewal, Reprogramming and Cardiomyogenesis view
Sawyer, Douglas B Oxidative stress in heart failure: what are we missing? view
Aisagbonhi, Omonigho; Rai, Meena; Ryzhov, Sergey; Atria, Nick; Feoktistov, Igor; Hatzopoulos, Antonis K Experimental myocardial infarction triggers canonical Wnt signaling and endothelial-tomesenchymal transition view


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