HS10 - Cooke Hub Site

Dr. Cooke’s translational research program is focused on vascular regeneration.  The focus is on restoration or stimulation of endothelial functions such as vasodilation and angiogenesis, using small molecules or stem cell therapies.  In his 25 years of translational endothelial biology, he first described and characterized the anti-atherogenic effects of endothelium-derived nitric oxide; the anti-angiogenic effect of the NO synthase inhibitor ADMA; the angiogenic pathway mediated by endothelial nicotinic acetylcholine receptors; the role for this pathway in states of pathological angiogenesis; and developed an antagonist of the pathway that is now in Phase II clinical trials.  His clinical research group has explored the use of angiogenic agents and adult stem cells in the treatment of peripheral arterial disease.  More recently, he has generated and characterized endothelial cells derived from human iPSCs, and explored their role in angiogenesis and vascular regeneration. Recent insights from the laboratory have clarified the role of innate immune signaling in nuclear reprogramming to pluripotency and therapeutic transdifferentiation for vascular disease.

Protocols and Reagents that are associated with this hub site can be accessed by logging into Synapse and searching the database from the appropriate list of protocols or reagents.  Click here for instructions to access Synapse.

Affiliated Investigator
User Name Full Name Institutional Affilication
eyakubov's picture
eyakubov Eduard Yakubov, Ph.D. Stanford University
nsayed's picture
nsayed Nazish Sayed M.D., Ph.D. Stanford University
mcastaneda's picture
mcastaneda Miguel A. Castañeda, M.BioT. Texas Methodist Hospital Research Institute
ibruno's picture
ibruno Ivone Bruno, Dr PH Houston Methodist Research Hospital
ytghebremariam's picture
ytghebremariam Yohannes Ghebremariam, PhD Texas Methodist Hospital Research Institute
dtaylor's picture
dtaylor Doris Taylor, Ph.D. University of Minnesota


Author(s) Title Link
Lee, Jieun; Cooke, John P The role of nicotine in the pathogenesis of atherosclerosis view
Pan, Yuqiong; Ouyang, Zhengqing; Wong, Wing Hung; Baker, Julie C A new FACS approach isolates hESC derived endoderm using transcription factors view
Burridge, Paul W; Thompson, Susan; Millrod, Michal A; Weinberg, Seth; Yuan, Xuan; Peters, Ann; Mahairaki, Vasiliki; Koliatsos, Vassilis E; Tung, Leslie; Zambidis, Elias T A universal system for highly efficient cardiac differentiation of human induced pluripotent stem cells that eliminates interline variability view
Gilbert, Penny M; Blau, Helen M Engineering a stem cell house into a home view
Razny, Urszula; Kiec- Wilk, Beata; Wator, Lukasz; Polus, Anna; Dyduch, Grzegorz; Solnica, Bogdan; Malecki, Maciej; Tomaszewska, Romana; Cooke, John P; Dembinska-Kiec, Aldona Increased nitric oxide availability attenuates high fat diet metabolic alterations and gene expression associated with insulin resistance view
Paz-Priel, Ido; Friedman, Alan C/EBPýý dysregulation in AML and ALL view
Leeper, Nicholas J; Cooke, John P MicroRNA and mechanisms of impaired angiogenesis in diabetes mellitus view
Guo, Hong; Friedman, Alan D Phosphorylation of RUNX1 by cyclin-dependent kinase reduces direct interaction with HDAC1 and HDAC3 view
Blau, Helen M; Pomerantz, Jason H Re"evolutionary" regenerative medicine view
Huang, Ngan F; Patlolla, Bhagat; Abilez, Oscar; Sharma, Himanshu; Rajadas, Jaykumar; Beygui, Ramin E; Zarins, Christopher K; Cooke, John P A matrix micropatterning platform for cell localization and stem cell fate determination view


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