HS10 - Cooke Hub Site

Dr. Cooke’s translational research program is focused on vascular regeneration.  The focus is on restoration or stimulation of endothelial functions such as vasodilation and angiogenesis, using small molecules or stem cell therapies.  In his 25 years of translational endothelial biology, he first described and characterized the anti-atherogenic effects of endothelium-derived nitric oxide; the anti-angiogenic effect of the NO synthase inhibitor ADMA; the angiogenic pathway mediated by endothelial nicotinic acetylcholine receptors; the role for this pathway in states of pathological angiogenesis; and developed an antagonist of the pathway that is now in Phase II clinical trials.  His clinical research group has explored the use of angiogenic agents and adult stem cells in the treatment of peripheral arterial disease.  More recently, he has generated and characterized endothelial cells derived from human iPSCs, and explored their role in angiogenesis and vascular regeneration. Recent insights from the laboratory have clarified the role of innate immune signaling in nuclear reprogramming to pluripotency and therapeutic transdifferentiation for vascular disease.

Protocols and Reagents that are associated with this hub site can be accessed by logging into Synapse and searching the database from the appropriate list of protocols or reagents.  Click here for instructions to access Synapse.

Post-Doctoral Fellow/Trainee
User Name Full Name Institutional Affilication
jchen2's picture
jchen2 Jinyu Chen Houston Methodist Research Hospital
skrishnamurthy's picture
skrishnamurthy Shashirekha Krishnamurthy Texas Methodist Hospital Research Institute
ffang's picture
ffang Fang Fang, Ph.D. Montana State University
nora.yucel's picture
nora.yucel Nora D. Yucel Stanford University
lgzhu's picture
lgzhu Laurence Zhu Houston Methodist Research Hospital
Affiliated Investigator
User Name Full Name Institutional Affilication
kchen2's picture
kchen2 Kaifu Chen, PhD Texas Methodist Hospital Research Institute
pkrishnamurthy's picture
pkrishnamurthy Prasanna Krishnamurthy, D.V.M., Ph.D. Houston Methodist Research Hospital
cfisher2's picture
cfisher2 Colleen Fisher, M.Sc. Texas Methodist Hospital Research Institute
ravisankar.sweta's picture
ravisankar.sweta Sweta Ravisankar Stanford University School of Medicine
eyakubov's picture
eyakubov Eduard Yakubov, Ph.D. Stanford University


Author(s) Title Link
Park, Tea Soon; Huo, Jeffrey S; Peters, Ann; Talbot Jr, C Conover; Verma, Karan; Zimmerlin, Ludovic; Kaplan, Ian M; Zambidis, Elias T Growth factor-activated stem cell circuits and stromal signals cooperatively accelerate non-integrated iPSC reprogramming of human myeloid progenitors view
Kawamura, Kazuhiro; Chen, Yuan; Shu, Yimin; Cheng, Yuan; Qiao, Jie; Behr, Barry; Pera, Renee A Reijo; Hsueh, Aaron J W Promotion of human early embryonic development and blastocyst outgrowth in vitro using autocrine/paracrine growth factors view
Quarto, Natalina; Leonard, Brian; Li, Shuli; Marchand, Melanie; Anderson, Erica; Behr, Barry; Francke, Uta; Reijo- Pera, Renee; Chiao, Eric; Longaker, Michael T Skeletogenic phenotype of human Marfan embryonic stem cells faithfully phenocopied by patientspecific induced-pluripotent stem cells view
Hong, SunHwa; Skaist, Alyza M; Wheelan, Sarah J; Friedman, Alan D AP-1 protein induction during monopoiesis favors C/EBP: AP-1 heterodimers over C/EBP homodimerization and stimulates FosB transcription view
Leeper, Nicholas J; Lee, Jason T; Cooke, John P Two decades of progress in vascular medicine view
Yang, William C; Swartz, James R A filter microplate assay for quantitative analysis of DNA binding proteins using fluorescent DNA view
Zhang, Li; Friedman, Alan D SHP2 tyrosine phosphatase stimulates CEBPA gene expression to mediate cytokinedependent granulopoiesis view
Cooke, John P; Ghebremariam, Yohannes T DDAH says NO to ADMA view
Paz-Priel, Ido; Houng, Simone; Dooher, Julia; Friedman, Alan D C/EBPýý and C/EBPýý oncoproteins regulate nfkb1 and displace histone deacetylases from NF-ýýB p50 homodimers to induce NF-ýýB target genes view
Cooke, John P; Ghebremariam, Yohannes T Dietary nitrate, nitric oxide, and restenosis view


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