HS10 - Cooke Hub Site

Dr. Cooke’s translational research program is focused on vascular regeneration.  The focus is on restoration or stimulation of endothelial functions such as vasodilation and angiogenesis, using small molecules or stem cell therapies.  In his 25 years of translational endothelial biology, he first described and characterized the anti-atherogenic effects of endothelium-derived nitric oxide; the anti-angiogenic effect of the NO synthase inhibitor ADMA; the angiogenic pathway mediated by endothelial nicotinic acetylcholine receptors; the role for this pathway in states of pathological angiogenesis; and developed an antagonist of the pathway that is now in Phase II clinical trials.  His clinical research group has explored the use of angiogenic agents and adult stem cells in the treatment of peripheral arterial disease.  More recently, he has generated and characterized endothelial cells derived from human iPSCs, and explored their role in angiogenesis and vascular regeneration. Recent insights from the laboratory have clarified the role of innate immune signaling in nuclear reprogramming to pluripotency and therapeutic transdifferentiation for vascular disease.

Protocols and Reagents that are associated with this hub site can be accessed by logging into Synapse and searching the database from the appropriate list of protocols or reagents.  Click here for instructions to access Synapse.

Post-Doctoral Fellow/Trainee
User Name Full Name Institutional Affilication
Nhuang's picture
Nhuang Ngan Huang Stanford University
dzhang's picture
dzhang Donghui Zhang, Ph.D. Boston Children's Hospital
tamai's picture
tamai Thach Mai Stanford University School of Medicine
darukesh's picture
darukesh Darukeshwara Joladarashi, Ph.D. Houston Methodist Research Hospital
eporpigl's picture
eporpigl Ermelinda Porpiglia Stanford University School of Medicine
atrajarajan's picture
atrajarajan Rajarajan Thandavarayan, Ph.D., Pharm.D. Houston Methodist Research Hospital
fmourkioti's picture
fmourkioti Foteini Mourkioti Stanford
gmatrone's picture
gmatrone Gianfranco Matrone Texas Methodist Hospital Research Institute
gzhou's picture
gzhou Gang Zhou, Ph.D. Houston Methodist Research Hospital
jramunas's picture
jramunas John Ramunas Stanford University


Author(s) Title Link
Thompson, Susan A; Burridge, Paul W; Lipke, Elizabeth A; Shamblott, Michael; Zambidis, Elias T; Tung, Leslie Engraftment of human embryonic stem cell derived cardiomyocytes improves conduction in an arrhythmogenic in vitro model view
Ghebremariam, Yohannes T; Erlanson, Daniel A; Yamada, Keisuke; Cooke, John P Development of a dimethylarginine dimethylaminohydrolase (DDAH) assay for highthroughput chemical screening view
Leeper, Nicholas J; Kullo, Iftikhar J; Cooke, John P Genetics of peripheral artery disease view
Byers, Blake; Lee, Hsiao-lu; Reijo Pera, Renee Modeling Parkinson's disease using induced pluripotent stem cells view
Gilbert, Penney M; Corbel, Stephane; Doyonnas, Regis; Havenstrite, Karen; Magnusson, Klas E G; Blau, Helen M A single cell bioengineering approach to elucidate mechanisms of adult stem cell self-renewal view
Gilbert, Penney M; Corbel, Stephane; Doyonnas, Regis; Havenstrite, Karen; Magnusson, Klas E G; Blau, Helen M A single cell bioengineering approach to elucidate mechanisms of adult stem cell self-renewal view
Medrano, Jose V; Ramathal, Cyril; Nguyen, Ha N; Simon, Carlos; Reijo Pera, Renee A Divergent RNA-binding proteins, DAZL and VASA, induce meiotic progression in human germ cells derived in vitro view
Cooke, John P Lymphangiogenesis: a potential new therapy for lymphedema? view
Huang, Ngan F; Okogbaa, Janet; Babakhanyan, Anna; Cooke, John P Bioluminescence imaging of stem cell-based therapeutics for vascular regeneration view
Chavez, Shawn L; Loewke, Kevin E; Han, Jinnuo; Moussavi, Farshid; Colls, Pere; Munne, Santiago; Behr, Barry; Reijo Pera, Renee A Dynamic blastomere behaviour reflects human embryo ploidy by the fourcell stage view


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