HS10 - Cooke Hub Site

Dr. Cooke’s translational research program is focused on vascular regeneration.  The focus is on restoration or stimulation of endothelial functions such as vasodilation and angiogenesis, using small molecules or stem cell therapies.  In his 25 years of translational endothelial biology, he first described and characterized the anti-atherogenic effects of endothelium-derived nitric oxide; the anti-angiogenic effect of the NO synthase inhibitor ADMA; the angiogenic pathway mediated by endothelial nicotinic acetylcholine receptors; the role for this pathway in states of pathological angiogenesis; and developed an antagonist of the pathway that is now in Phase II clinical trials.  His clinical research group has explored the use of angiogenic agents and adult stem cells in the treatment of peripheral arterial disease.  More recently, he has generated and characterized endothelial cells derived from human iPSCs, and explored their role in angiogenesis and vascular regeneration. Recent insights from the laboratory have clarified the role of innate immune signaling in nuclear reprogramming to pluripotency and therapeutic transdifferentiation for vascular disease.

Protocols and Reagents that are associated with this hub site can be accessed by logging into Synapse and searching the database from the appropriate list of protocols or reagents.  Click here for instructions to access Synapse.

members: 
Post-Doctoral Fellow/Trainee
User Name Full Name Institutional Affilication
nxia's picture
nxia Ninuo Xia, Ph.D. Montana State University
pjeyabal's picture
pjeyabal Prince Jeyabal, Ph.D. Houston Methodist Research Hospital
yli's picture
yli Yanhui Li, PhD Houston Methodist Research Hospital
qgu's picture
qgu Qilin Gu, PhD Texas Methodist Hospital Research Institute
gyepuri's picture
gyepuri Gautham S. Yepuri, M.Sc.,Ph.D. Texas Methodist Hospital Research Institute
smeng's picture
smeng Shu Meng, M.D., Ph.D. Houston Methodist Hospital Research Institute
ssuresh's picture
ssuresh Sahana Suresh Babu, Ph.D. Houston Methodist Research Hospital
durruthy's picture
durruthy Jens Durruthy-Durruthy Stanford University School of Medicine
rmao's picture
rmao Renfang Mao, M.D., Ph.D. Houston Methodist Research Hospital
netoledanofurman's picture
netoledanofurman Naama Toledano Furman, PhD Houston Methodist Research Insitute

Pages

Publication: 
Author(s) Title Link
Sengupta, Debanti; Gilbert, Penney M; Johnson, Kyle J; Blau, Helen M; Heilshorn, Sarah C Protein-engineered biomaterials to generate human skeletal muscle mimics view
Sengupta, Debanti; Gilbert, Penney M; Johnson, Kyle J; Blau, Helen M; Heilshorn, Sarah C Protein-engineered biomaterials to generate human skeletal muscle mimics view
Lee, Jieun; Sayed, Nazish; Hunter, Arwen; Au, Kin Fai; Wong, Wing H; Mocarski, Edward S; Pera, Renee Reijo; Yakubov, Eduard; Cooke, John P Activation of innate immunity is required for efficient nuclear reprogramming view
Blazeski, Adriana; Zhu, Renjun; Hunter, David W; Weinberg, Seth H; Zambidis, Elias T; Tung, Leslie Cardiomyocytes derived from human induced pluripotent stem cells as models for normal and diseased cardiac electrophysiology and contractility view
Blazeski, Adriana; Zhu, Renjun; Hunter, David W; Weinberg, Seth H; Boheler, Kenneth R; Zambidis, Elias T; Tung, Leslie Electrophysiological and contractile function of cardiomyocytes derived from human embryonic stem cells view
Wong, Wing Tak; Huang, Ngan F; Botham, Crystal M; Sayed, Nazish; Cooke, John P Endothelial cells derived from nuclear reprogramming view
Ge, Xiaohu; Wang, INing E; Toma, Ildiko; Sebastiano, Vittorio; Liu, Jianwei; Butte, Manish J; Reijo Pera, Renee A; Yang, Phillip C Human amniotic mesenchymal stem cellderived induced pluripotent stem cells may generate a universal source of cardiac cells view
Chung, Cindy; Anderson, Erica; Pera, Renee Reijo; Pruitt, Beth L; Heilshorn, Sarah C Hydrogel crosslinking density regulates temporal contractility of human embryonic stem cellderived cardiomyocytes in 3D cultures view
Panicker, Leelamma M; Miller, Diana; Park, Tea Soon; Patel, Brijesh; Azevedo, Judi L; Awad, Ola; Masood, M Athar; Veenstra, Timothy D; Goldin, Ehud; Stubblefield, Barbara K; Tayebi, Nahid; Polumuri, Swamy K; Vogel, Stefanie N; Sidransky, Ellen; Zambidis, Elias T; Feldman, Ricardo A Induced pluripotent stem cell model recapitulates pathologic hallmarks of Gaucher disease view
Lai, Edwina S; Huang, Ngan F; Cooke, John P; Fuller, Gerald G Aligned nanofibrillar collagen regulates endothelial organization and migration view

Pages

Copyright ©2013 NHLBI Progenitor Cell Biology Consortium.

University of Maryland School of Medicine logo

National Heart Blood and Lung Institute logo