Dr. Cooke’s translational research program is focused on vascular regeneration. The focus is on restoration or stimulation of endothelial functions such as vasodilation and angiogenesis, using small molecules or stem cell therapies. In his 25 years of translational endothelial biology, he first described and characterized the anti-atherogenic effects of endothelium-derived nitric oxide; the anti-angiogenic effect of the NO synthase inhibitor ADMA; the angiogenic pathway mediated by endothelial nicotinic acetylcholine receptors; the role for this pathway in states of pathological angiogenesis; and developed an antagonist of the pathway that is now in Phase II clinical trials. His clinical research group has explored the use of angiogenic agents and adult stem cells in the treatment of peripheral arterial disease. More recently, he has generated and characterized endothelial cells derived from human iPSCs, and explored their role in angiogenesis and vascular regeneration. Recent insights from the laboratory have clarified the role of innate immune signaling in nuclear reprogramming to pluripotency and therapeutic transdifferentiation for vascular disease.
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User Name | Full Name | Institutional Affilication | |
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jchen2 | Jinyu Chen | Houston Methodist Research Hospital | |
skrishnamurthy | Shashirekha Krishnamurthy | Texas Methodist Hospital Research Institute | |
eporpigl | Ermelinda Porpiglia | Stanford University School of Medicine | |
lgzhu | Laurence Zhu | Houston Methodist Research Hospital | |
fmourkioti | Foteini Mourkioti | Stanford | |
gmatrone | Gianfranco Matrone | Texas Methodist Hospital Research Institute | |
jramunas | John Ramunas | Stanford University | |
ffang | Fang Fang, Ph.D. | Montana State University | |
alacey | Alexandra Lacey | Texas A&M University | |
nora.yucel | Nora D. Yucel | Stanford University |
Author(s) | Title | Link |
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Sengupta, Debanti; Gilbert, Penney M; Johnson, Kyle J; Blau, Helen M; Heilshorn, Sarah C | Protein-engineered biomaterials to generate human skeletal muscle mimics | view |
Sengupta, Debanti; Gilbert, Penney M; Johnson, Kyle J; Blau, Helen M; Heilshorn, Sarah C | Protein-engineered biomaterials to generate human skeletal muscle mimics | view |
Lee, Jieun; Sayed, Nazish; Hunter, Arwen; Au, Kin Fai; Wong, Wing H; Mocarski, Edward S; Pera, Renee Reijo; Yakubov, Eduard; Cooke, John P | Activation of innate immunity is required for efficient nuclear reprogramming | view |
Blazeski, Adriana; Zhu, Renjun; Hunter, David W; Weinberg, Seth H; Zambidis, Elias T; Tung, Leslie | Cardiomyocytes derived from human induced pluripotent stem cells as models for normal and diseased cardiac electrophysiology and contractility | view |
Blazeski, Adriana; Zhu, Renjun; Hunter, David W; Weinberg, Seth H; Boheler, Kenneth R; Zambidis, Elias T; Tung, Leslie | Electrophysiological and contractile function of cardiomyocytes derived from human embryonic stem cells | view |
Wong, Wing Tak; Huang, Ngan F; Botham, Crystal M; Sayed, Nazish; Cooke, John P | Endothelial cells derived from nuclear reprogramming | view |
Ge, Xiaohu; Wang, INing E; Toma, Ildiko; Sebastiano, Vittorio; Liu, Jianwei; Butte, Manish J; Reijo Pera, Renee A; Yang, Phillip C | Human amniotic mesenchymal stem cellderived induced pluripotent stem cells may generate a universal source of cardiac cells | view |
Chung, Cindy; Anderson, Erica; Pera, Renee Reijo; Pruitt, Beth L; Heilshorn, Sarah C | Hydrogel crosslinking density regulates temporal contractility of human embryonic stem cellderived cardiomyocytes in 3D cultures | view |
Panicker, Leelamma M; Miller, Diana; Park, Tea Soon; Patel, Brijesh; Azevedo, Judi L; Awad, Ola; Masood, M Athar; Veenstra, Timothy D; Goldin, Ehud; Stubblefield, Barbara K; Tayebi, Nahid; Polumuri, Swamy K; Vogel, Stefanie N; Sidransky, Ellen; Zambidis, Elias T; Feldman, Ricardo A | Induced pluripotent stem cell model recapitulates pathologic hallmarks of Gaucher disease | view |
Lai, Edwina S; Huang, Ngan F; Cooke, John P; Fuller, Gerald G | Aligned nanofibrillar collagen regulates endothelial organization and migration | view |
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