HS10 - Cooke Hub Site

Dr. Cooke’s translational research program is focused on vascular regeneration.  The focus is on restoration or stimulation of endothelial functions such as vasodilation and angiogenesis, using small molecules or stem cell therapies.  In his 25 years of translational endothelial biology, he first described and characterized the anti-atherogenic effects of endothelium-derived nitric oxide; the anti-angiogenic effect of the NO synthase inhibitor ADMA; the angiogenic pathway mediated by endothelial nicotinic acetylcholine receptors; the role for this pathway in states of pathological angiogenesis; and developed an antagonist of the pathway that is now in Phase II clinical trials.  His clinical research group has explored the use of angiogenic agents and adult stem cells in the treatment of peripheral arterial disease.  More recently, he has generated and characterized endothelial cells derived from human iPSCs, and explored their role in angiogenesis and vascular regeneration. Recent insights from the laboratory have clarified the role of innate immune signaling in nuclear reprogramming to pluripotency and therapeutic transdifferentiation for vascular disease.

Protocols and Reagents that are associated with this hub site can be accessed by logging into Synapse and searching the database from the appropriate list of protocols or reagents.  Click here for instructions to access Synapse.

Lead Principal Investigator
User Name Full Name Institutional Affilication
jcooke's picture
jcooke John P. Cooke, M.D., Ph.D. The Houston Methodist Research Institute
User Name Full Name Institutional Affilication
wwong's picture
wwong Wing Wong, Ph.D. Stanford University
rkornberg's picture
rkornberg Roger Kornberg, Ph.D. Stanford University
hblau's picture
hblau Helen Blau, Ph.D. Stanford University
Post-Doctoral Fellow/Trainee
User Name Full Name Institutional Affilication
smruti's picture
smruti Smruti Madan Phadnis Stanford
sma's picture
sma Shuangtao Ma, M.D., M.Sc. Texas Methodist Hospital Research Institute
alacey's picture
alacey Alexandra Lacey Texas A&M University
nxia's picture
nxia Ninuo Xia, Ph.D. Montana State University
pjeyabal's picture
pjeyabal Prince Jeyabal, Ph.D. Houston Methodist Research Hospital
smeng's picture
smeng Shu Meng, M.D., Ph.D. Houston Methodist Hospital Research Institute


Author(s) Title Link
Huang, Ngan F; Okogbaa, Janet; Lee, Jerry C; Jha, Arshi; Zaitseva, Tatiana S; Paukshto, Michael V; Sun, John S; Punjya, Niraj; Fuller, Gerald G; Cooke, John P The modulation of endothelial cell morphology, function, and survival using anisotropic nanofibrillar collagen scaffolds view
Huang, Ngan F; Lai, Edwina S; Ribeiro, Alexandre J S; Pan, Stephen; Pruitt, Beth L; Fuller, Gerald G; Cooke, John P Spatial patterning of endothelium modulates cell morphology, adhesiveness and transcriptional signature view
Bhutani, Nidhi; Decker, Matthew N; Brady, Jennifer J; Bussat, Rose T; Burns, David M; Corbel, Stephane Y; Blau, Helen M A critical role for AID in the initiation of reprogramming to induced pluripotent stem cells view
Cooke, John P Therapeutic transdifferentiation: a novel approach for vascular disease view
Huo, Jeffrey S; Zambidis, Elias T Pivots of pluripotency: the roles of non-coding RNA in regulating embryonic and induced pluripotent stem cells view
Wen, Yan; Wani, Prachi; Zhou, Lu; Baer, Tom; Phadnis, Smruti Madan; Reijo Pera, Renee A; Chen, Bertha Reprogramming of fibroblasts from older women with pelvic floor disorders alters cellular behavior associated with donor age view
Rufaihah, Abdul Jalil; Huang, Ngan F; Kim, Jeanna; Herold, Joerg; Volz, Katharina S; Park, Tea Soon; Lee, Jerry C; Zambidis, Elias T; Reijo-Pera, Renee; Cooke, John P Human induced pluripotent stem cell-derived endothelial cells exhibit functional heterogeneity view
White, Mark P; Rufaihah, Abdul J; Liu, Lei; Ghebremariam, Yohannes T; Ivey, Kathryn N; Cooke, John P; Srivastava, Deepak Limited gene expression variation in human embryonic stem cell and induced pluripotent stem cell-derived endothelial cells view
Hong, Guosong; Lee, Jerry C; Robinson, Joshua T; Raaz, Uwe; Xie, Liming; Huang, Ngan F; Cooke, John P; Dai, Hongjie Multifunctional in vivo vascular imaging using near-infrared II fluorescence view
Lee, Jieun; Cooke, John P Nicotine and pathological angiogenesis view


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