HS09 - Bernstein Hub Site
The research in Dr. Bernstein's lab has primarily focused on developmental aspects of hematopoiesis with the specific goal of developing novel therapeutic modalities. In these efforts we have identified maturation linked cell surface antigens and have utilized this information for developing methods for targeted therapy of hematologic malignancies and for isolating and characterizing normal and malignant human hematopoietic stem cells. These studies have led to the development of stem cell transplantation using isolated CD34+ cells and for Notch ligand-induced expansion of repopulating cell numbers currently being tested in a clinical trial of cord blood transplantation.
Protocols and Reagents that are associated with this hub site can be accessed by logging into Synapse and searching the database from the appropriate list of protocols or reagents. Click here for instructions to access Synapse.
| User Name | Full Name | Institutional Affilication | |
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ibernstein | Irwin D. Bernstein, M.D. | Fred Hutchinson Cancer Research Center |
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Mervin Yoder | Mervin C. Yoder, M.D. | IU |
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arobitaille | Aaron Robitaille, Ph.D. | Univversity of Washington |
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raedunc | Raedun Clarke, Ph.D. | University of Toronto |
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dahlberg | Ann E. Dahlberg, Ph.D. | Fred Hutchinson Cancer Research Center |
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bhadland | Brandon Hadland | Fred Hutchinson Cancer Research Center |
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quyl | Quy Le | Fred Hutchinson Cancer Research Center |
| User Name | Full Name | Institutional Affilication | |
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rgottardo | Raphael Gottardo | FHCRC |
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gkeller | Gordon Keller, Ph.D. | University Health Network |
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ecohen | Ethan David Cohen | University of Rochester School of Medicine |
| Author(s) | Title | Link |
|---|---|---|
| Zhu, Jiang; Adli, Mazhar; Zou, James Y; Verstappen, Griet; Coyne, Michael; Zhang, Xiaolan; Durham, Timothy; Miri, Mohammad; Deshpande, Vikram; De Jager, Philip L; Bennett, David A; Houmard, Joseph A; Muoio, Deborah M; Onder, Tamer T; Camahort, Ray; Cowan, Chad A; Meissner, Alexander; Epstein, Charles B; Shoresh, Noam; Bernstein, Bradley E | Genome-wide chromatin state transitions associated with developmental and environmental cues | view |
| Hadland, Brandon K; Bernstein, Irwin D | Visualizing human ESC-derived hematopoiesis | view |
| James, Richard G; Davidson, Kathryn C; Bosch, Katherine A; Biechele, Travis L; Robin, Nicholas C; Taylor, Russell J; Major, Michael B; Camp, Nathan D; Fowler, Kerry; Martins, Timothy J; Moon, Randall T | WIKI4, a novel inhibitor of tankyrase and Wnt/ýý-catenin signaling | view |
| Abdel-Wahab, Omar; Adli, Mazhar; LaFave, Lindsay M; Gao, Jie; Hricik, Todd; Shih, Alan H; Pandey, Suveg; Patel, Jay P; Chung, Young Rock; Koche, Richard; Perna, Fabiana; Zhao, Xinyang; Taylor, Jordan E; Park, Christopher Y; Carroll, Martin; Melnick, Ari; Nimer, Stephen D; Jaffe, Jacob D; Aifantis, Iannis; Bernstein, Bradley E; Levine, Ross L | ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression | view |
| Parker, Maura H; Loretz, Carol; Tyler, Ashlee E; Duddy, William J; Hall, John K; Olwin, Bradley B; Bernstein, Irwin D; Storb, Rainer; Tapscott, Stephen J | Activation of Notch signaling during ex vivo expansion maintains donor muscle cell engraftment | view |
| Kennedy, Marion; Awong, Geneve; Sturgeon, Christopher M; Ditadi, Andrea; LaMotte-Mohs, Ross; Zuniga-Pflucker, Juan Carlos; Keller, Gordon | T lymphocyte potential marks the emergence of definitive hematopoietic progenitors in human pluripotent stem cell differentiation cultures | view |
| Dahlberg, Ann; Delaney, Colleen; Bernstein, Irwin D | Ex vivo expansion of human hematopoietic stem and progenitor cells | view |
Copyright ©2013 NHLBI Progenitor Cell Biology Consortium.
