HS09 - Bernstein Hub Site

The research in Dr. Bernstein's lab has primarily focused on developmental aspects of hematopoiesis with the specific goal of developing novel therapeutic modalities. In these efforts we have identified maturation linked cell surface antigens and have utilized this information for developing methods for targeted therapy of hematologic malignancies and for isolating and characterizing normal and malignant human hematopoietic stem cells. These studies have led to the development of stem cell transplantation using isolated CD34+ cells and for Notch ligand-induced expansion of repopulating cell numbers currently being tested in a clinical trial of cord blood transplantation.

Protocols and Reagents that are associated with this hub site can be accessed by logging into Synapse and searching the database from the appropriate list of protocols or reagents.  Click here for instructions to access Synapse.

members: 
Principal Investigator
User Name Full Name Institutional Affilication
ibernstein's picture
ibernstein Irwin D. Bernstein, M.D. Fred Hutchinson Cancer Research Center
Co-PI/Co-Investigator
User Name Full Name Institutional Affilication
Mervin Yoder's picture
Mervin Yoder Mervin C. Yoder, M.D. IU
Post-Doctoral Fellow/Trainee
User Name Full Name Institutional Affilication
raedunc's picture
raedunc Raedun Clarke, Ph.D. University of Toronto
dahlberg's picture
dahlberg Ann E. Dahlberg, Ph.D. Fred Hutchinson Cancer Research Center
bhadland's picture
bhadland Brandon Hadland Fred Hutchinson Cancer Research Center
quyl's picture
quyl Quy Le Fred Hutchinson Cancer Research Center
arobitaille's picture
arobitaille Aaron Robitaille, Ph.D. Univversity of Washington
Affiliated Investigator
User Name Full Name Institutional Affilication
rgottardo's picture
rgottardo Raphael Gottardo FHCRC
gkeller's picture
gkeller Gordon Keller, Ph.D. University Health Network
ecohen's picture
ecohen Ethan David Cohen University of Rochester School of Medicine
Publication: 
Author(s) Title Link
Zhu, Jiang; Adli, Mazhar; Zou, James Y; Verstappen, Griet; Coyne, Michael; Zhang, Xiaolan; Durham, Timothy; Miri, Mohammad; Deshpande, Vikram; De Jager, Philip L; Bennett, David A; Houmard, Joseph A; Muoio, Deborah M; Onder, Tamer T; Camahort, Ray; Cowan, Chad A; Meissner, Alexander; Epstein, Charles B; Shoresh, Noam; Bernstein, Bradley E Genome-wide chromatin state transitions associated with developmental and environmental cues view
Hadland, Brandon K; Bernstein, Irwin D Visualizing human ESC-derived hematopoiesis view
James, Richard G; Davidson, Kathryn C; Bosch, Katherine A; Biechele, Travis L; Robin, Nicholas C; Taylor, Russell J; Major, Michael B; Camp, Nathan D; Fowler, Kerry; Martins, Timothy J; Moon, Randall T WIKI4, a novel inhibitor of tankyrase and Wnt/ýý-catenin signaling view
Abdel-Wahab, Omar; Adli, Mazhar; LaFave, Lindsay M; Gao, Jie; Hricik, Todd; Shih, Alan H; Pandey, Suveg; Patel, Jay P; Chung, Young Rock; Koche, Richard; Perna, Fabiana; Zhao, Xinyang; Taylor, Jordan E; Park, Christopher Y; Carroll, Martin; Melnick, Ari; Nimer, Stephen D; Jaffe, Jacob D; Aifantis, Iannis; Bernstein, Bradley E; Levine, Ross L ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression view
Parker, Maura H; Loretz, Carol; Tyler, Ashlee E; Duddy, William J; Hall, John K; Olwin, Bradley B; Bernstein, Irwin D; Storb, Rainer; Tapscott, Stephen J Activation of Notch signaling during ex vivo expansion maintains donor muscle cell engraftment view
Kennedy, Marion; Awong, Geneve; Sturgeon, Christopher M; Ditadi, Andrea; LaMotte-Mohs, Ross; Zuniga-Pflucker, Juan Carlos; Keller, Gordon T lymphocyte potential marks the emergence of definitive hematopoietic progenitors in human pluripotent stem cell differentiation cultures view
Dahlberg, Ann; Delaney, Colleen; Bernstein, Irwin D Ex vivo expansion of human hematopoietic stem and progenitor cells view

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