HS08 - Daley Hub Site

George Daley's lab focuses on stem cell biology, with an emphasis on somatic cell reprogramming, hematopoietic differentiation from human and mouse pluripotent stem cells, and common mechanisms in reprogramming and cancer. His laboratory has pioneered the study of murine and human cell culture models of leukemia and genetic bone marrow disease and the role of the Lin28/let-7 pathway in human cancer and metabolic disease.

Protocols and Reagents that are associated with this hub site can be accessed by logging into Synapse and searching the database from the appropriate list of protocols or reagents.  Click here for instructions to access Synapse.

members: 
Principal Investigator
User Name Full Name Institutional Affilication
gdaley's picture
gdaley George Q. Daley, M.D., Ph.D. Children's Hospital Boston
Co-PI/Co-Investigator
User Name Full Name Institutional Affilication
kdcrawford's picture
kdcrawford Keith Crawford, M.D., Ph.D. Harvard Medical School, Brigham & Women's Hospital
Muhammad Ashraf's picture
Muhammad Ashraf Muhammad Ashraf, Ph.D UC
Post-Doctoral Fellow/Trainee
User Name Full Name Institutional Affilication
yi-fen.lu's picture
yi-fen.lu Yi-Fen Lu Boston Children's Hospital
emacari's picture
emacari Elizabeth Macari HHMI/Children's Hospital
peter.geon's picture
peter.geon Peter Geon Kim Harvard Medical School
sdoulatov's picture
sdoulatov Sergei Doulatov, Ph.D. Boston Children's Hospital
jmandelb's picture
jmandelb Joseph Mandelbaum Boston Children's Hospital
gmaclean's picture
gmaclean Glenn MacLean, Ph.D. Children's Hospital Boston
Affiliated Investigator
User Name Full Name Institutional Affilication
tschlaeger's picture
tschlaeger Thorsten Schlaeger Children's Hospital Boston
Publication: 
Author(s) Title Link
Lengerke, Claudia; Wingert, Rebecca; Beeretz, Michael; Grauer, Matthias; Schmidt, Anne G; Konantz, Martina; Daley, George Q; Davidson, Alan J Interactions between Cdx genes and retinoic acid modulate early cardiogenesis view
Shyh-Chang, Ng; Daley, George Q Lin28: primal regulator of growth and metabolism in stem cells view
Cherry, Anne B C; Gagne, Katelyn E; McLoughlin, Erin M; Baccei, Anna; Gorman, Bryan; Hartung, Odelya; Miller, Justine D; Zhang, Jin; Zon, Rebecca L; Ince, Tan A; Neufeld, Ellis J; Lerou, Paul H; Fleming, Mark D; Daley, George Q; Agarwal, Suneet Induced Pluripotent Stem Cells with a Pathological Mitochondrial DNA Deletion view
Morris, Samantha A; Daley, George Q A blueprint for engineering cell fate: current technologies to reprogram cell identity view
Shyh-Chang, Ng; Locasale, Jason W; Lyssiotis, Costas A; Zheng, Yuxiang; Teo, Ren Yi; Ratanasirintrawoot, Sutheera; Zhang, Jin; Onder, Tamer; Unternaehrer, Juli J; Zhu, Hao; Asara, John M; Daley, George Q; Cantley, Lewis C Influence of threonine metabolism on Sadenosylmethionine and histone methylation view
Cherry, Anne B C; Daley, George Q Reprogrammed cells for disease modeling and regenerative medicine view
Kim, Peter Geon; Albacker, Colleen E; Lu, Yi-fen; Jang, Ilho; Lim, Yoowon; Heffner, Garrett C; Arora, Natasha; Bowman, Teresa V; Lin, Michelle I; Lensch, M William; De Los Angeles, Alejandro; Zon, Leonard I; Loewer, Sabine; Daley, George Q Signaling axis involving Hedgehog, Notch, and Scl promotes the embryonic endothelialto- hematopoietic transition view
Zhang, Jin; Nuebel, Esther; Daley, George Q; Koehler, Carla M; Teitell, Michael A Metabolic Regulation in Pluripotent Stem Cells during Reprogramming and Self-Renewal view
McKinney-Freeman, Shannon; Cahan, Patrick; Li, Hu; Lacadie, Scott A; Huang, Hsuan-Ting; Curran, Matthew; Loewer, Sabine; Naveiras, Olaia; Kathrein, Katie L; Konantz, Martina; Langdon, Erin M; Lengerke, Claudia; Zon, Leonard I; Collins, James J; Daley, George Q The transcriptional landscape of hematopoietic stem cell ontogeny view
Maclean, Glenn A; Menne, Tobias F; Guo, Guoji; Sanchez, Danielle J; Park, In- Hyun; Daley, George Q; Orkin, Stuart H Altered hematopoiesis in trisomy 21 as revealed through in vitro differentiation of isogenic human pluripotent cells view

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