HS05 - Torok-Storb Hub Site

The long-term maintenance of blood cell production requires that a balance between stem cell replication and differentiation be maintained regardless of the physiological demands for mature, functional cells. Even in cases of extreme hematopoietic demand, exemplified by total body irradiation and stem cell transplantation, a cohort of stem cells will remain undifferentiated, yet presumably divide in order to replenish the stem cell pool. Although the mechanisms responsible for preventing stem cell differentiation have not been identified, studies conducted to understand this phenomenon suggest that regulatory signals involve cellular interactions with direct cell-cell contact as well as indirect interactions mediated by factors or matrix, both of which occur within the marrow microenvironment (ME).

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