The long-term maintenance of blood cell production requires that a balance between stem cell replication and differentiation be maintained regardless of the physiological demands for mature, functional cells. Even in cases of extreme hematopoietic demand, exemplified by total body irradiation and stem cell transplantation, a cohort of stem cells will remain undifferentiated, yet presumably divide in order to replenish the stem cell pool. Although the mechanisms responsible for preventing stem cell differentiation have not been identified, studies conducted to understand this phenomenon suggest that regulatory signals involve cellular interactions with direct cell-cell contact as well as indirect interactions mediated by factors or matrix, both of which occur within the marrow microenvironment (ME).
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User Name | Full Name | Institutional Affilication | |
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btorokst | Beverly Torok-Storb, Ph.D., M.Ed. | Fred Hutchinson Cancer Research Center |
User Name | Full Name | Institutional Affilication | |
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mfero | Matthew Fero, M.D. | Fred Hutchinson Cancer Research Center | |
ppaddison | Patrick Paddison, Ph.D. | Fred Hutchinson CRC | |
sheimfeld | Shelly Heimfeld, Ph.D. | Fred Hutchinson CRC | |
David W. Emery | David W. Emery | University of Washington | |
tblau | C. Anthony Blau, M.D. | University of Washington, Fred Hutchinson Cancer Research Center |
User Name | Full Name | Institutional Affilication | |
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suryak | Surya Kotha | University of Washington | |
ebelay | Eyayu Belay | University of Washington | |
aadams | Amie B. Adams, M.Eng. | University of Washington | |
ramakrishnan | Aravind Ramakrishnan, M.D. | Fred Hutchinson Cancer Research Center |
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