HS03 - Friedman Hub Site

Dr. Friedman investigates mechanisms through which normal proteins control the formation of bone marrow stem cells and how these stem cells then develop into neutrophils and monocytes. He is also studying how normal bone marrow cells become transformed into acute myeloid leukemia (AML). In conducting these studies he focuses on two proteins, RUNX1 and C/EBPa, which regulate normal bone marrow development but are also commonly mutated in AML. Dr. Friedman is attempting to build on his basic research to develop useful clinical applications. In particular, he is pursuing small molecules that interfere with the action of leukemic RUNX1 or C/EBPa proteins as potential novel therapies for AML, and he is investigating means to expand normal blood stem cells to benefit patients with marrow failure or those many patients receiving chemotherapy who would benefit from blood product support to avoid anemia, bleeding, and infections.

Protocols and Reagents that are associated with this hub site can be accessed by logging into Synapse and searching the database from the appropriate list of protocols or reagents.  Click here for instructions to access Synapse.

members: 
Principal Investigator
User Name Full Name Institutional Affilication
afriedman's picture
afriedman Alan D. Friedman, M.D. Johns Hopkins University
Co-PI/Co-Investigator
User Name Full Name Institutional Affilication
ezambidis's picture
ezambidis Elias Zambidis, M.D., Ph.D. Johns Hopkins University
sbaylin's picture
sbaylin Stephen Baylin, M.D. Johns Hopkins University
Post-Doctoral Fellow/Trainee
User Name Full Name Institutional Affilication
tpark's picture
tpark Tea Soon Park, Ph.D. The Johns Hopkins School of Medicine
lzimme's picture
lzimme Ludovic Zimmerlin Johns Hopkins
dsteppan's picture
dsteppan Diana Steppan, Ph.D. Johns Hopkins University
mcortes's picture
mcortes Marina Cortes JHMI
jhuo's picture
jhuo Jeffrey S Huo, M.D., Ph.D. Johns Hopkins University
Affiliated Investigator
User Name Full Name Institutional Affilication
hguo's picture
hguo Hong Guo, M.D., Ph.D. Johns Hopkins
Publication: 
Author(s) Title Link
Huo, Jeffrey S; Zambidis, Elias T Pivots of pluripotency: the roles of non-coding RNA in regulating embryonic and induced pluripotent stem cells view
Rufaihah, Abdul Jalil; Huang, Ngan F; Kim, Jeanna; Herold, Joerg; Volz, Katharina S; Park, Tea Soon; Lee, Jerry C; Zambidis, Elias T; Reijo-Pera, Renee; Cooke, John P Human induced pluripotent stem cellderived endothelial cells exhibit functional heterogeneity view
White, Mark P; Rufaihah, Abdul J; Liu, Lei; Ghebremariam, Yohannes T; Ivey, Kathryn N; Cooke, John P; Srivastava, Deepak Limited gene expression variation in human embryonic stem cell and induced pluripotent stem cell-derived endothelial cells view
Blazeski, Adriana; Zhu, Renjun; Hunter, David W; Weinberg, Seth H; Zambidis, Elias T; Tung, Leslie Cardiomyocytes derived from human induced pluripotent stem cells as models for normal and diseased cardiac electrophysiology and contractility view
Blazeski, Adriana; Zhu, Renjun; Hunter, David W; Weinberg, Seth H; Boheler, Kenneth R; Zambidis, Elias T; Tung, Leslie Electrophysiological and contractile function of cardiomyocytes derived from human embryonic stem cells view
Panicker, Leelamma M; Miller, Diana; Park, Tea Soon; Patel, Brijesh; Azevedo, Judi L; Awad, Ola; Masood, M Athar; Veenstra, Timothy D; Goldin, Ehud; Stubblefield, Barbara K; Tayebi, Nahid; Polumuri, Swamy K; Vogel, Stefanie N; Sidransky, Ellen; Zambidis, Elias T; Feldman, Ricardo A Induced pluripotent stem cell model recapitulates pathologic hallmarks of Gaucher disease view
Thompson, Susan A; Burridge, Paul W; Lipke, Elizabeth A; Shamblott, Michael; Zambidis, Elias T; Tung, Leslie Engraftment of human embryonic stem cell derived cardiomyocytes improves conduction in an arrhythmogenic in vitro model view
Easwaran, Hariharan; Johnstone, Sarah E; Van Neste, Leander; Ohm, Joyce; Mosbruger, Tim; Wang, Qiuju; Aryee, Martin J; Joyce, Patrick; Ahuja, Nita; Weisenberger, Dan; Collisson, Eric; Zhu, Jingchun; Yegnasubramanian, Srinivasan; Matsui, William; Baylin, Stephen B A DNA hypermethylation module for the stem/progenitor cell signature of cancer view
Guo, Hong; Ma, Ou; Speck, Nancy A; Friedman, Alan D Runx1 deletion or dominant inhibition reduces Cebpa transcription via conserved promoter and distal enhancer sites to favor monopoiesis over granulopoiesis view
Cheng, Linzhao; Hansen, Nancy F; Zhao, Ling; Du, Yutao; Zou, Chunlin; Donovan, Frank X; Chou, Bin-Kuan; Zhou, Guangyu; Li, Shijie; Dowey, Sarah N; Ye, Zhaohui; NISC Comparative Sequencing Program; Chandrasekharappa, Settara C; Yang, Huanming; Mullikin, James C; Liu, P Paul Low incidence of DNA sequence variation in human induced pluripotent stem cells generated by nonintegrating plasmid expression view

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