HS03 - Friedman Hub Site
Dr. Friedman investigates mechanisms through which normal proteins control the formation of bone marrow stem cells and how these stem cells then develop into neutrophils and monocytes. He is also studying how normal bone marrow cells become transformed into acute myeloid leukemia (AML). In conducting these studies he focuses on two proteins, RUNX1 and C/EBPa, which regulate normal bone marrow development but are also commonly mutated in AML. Dr. Friedman is attempting to build on his basic research to develop useful clinical applications. In particular, he is pursuing small molecules that interfere with the action of leukemic RUNX1 or C/EBPa proteins as potential novel therapies for AML, and he is investigating means to expand normal blood stem cells to benefit patients with marrow failure or those many patients receiving chemotherapy who would benefit from blood product support to avoid anemia, bleeding, and infections.
Protocols and Reagents that are associated with this hub site can be accessed by logging into Synapse and searching the database from the appropriate list of protocols or reagents. Click here for instructions to access Synapse.
| User Name | Full Name | Institutional Affilication | |
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afriedman | Alan D. Friedman, M.D. | Johns Hopkins University |
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sbaylin | Stephen Baylin, M.D. | Johns Hopkins University |
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ezambidis | Elias Zambidis, M.D., Ph.D. | Johns Hopkins University |
| User Name | Full Name | Institutional Affilication | |
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jhuo | Jeffrey S Huo, M.D., Ph.D. | Johns Hopkins University |
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tpark | Tea Soon Park, Ph.D. | The Johns Hopkins School of Medicine |
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lzimme | Ludovic Zimmerlin | Johns Hopkins |
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dsteppan | Diana Steppan, Ph.D. | Johns Hopkins University |
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mcortes | Marina Cortes | JHMI |
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hguo | Hong Guo, M.D., Ph.D. | Johns Hopkins |
| Author(s) | Title | Link |
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| Huo, Jeffrey S; Zambidis, Elias T | Pivots of pluripotency: the roles of non-coding RNA in regulating embryonic and induced pluripotent stem cells | view |
| Rufaihah, Abdul Jalil; Huang, Ngan F; Kim, Jeanna; Herold, Joerg; Volz, Katharina S; Park, Tea Soon; Lee, Jerry C; Zambidis, Elias T; Reijo-Pera, Renee; Cooke, John P | Human induced pluripotent stem cellderived endothelial cells exhibit functional heterogeneity | view |
| White, Mark P; Rufaihah, Abdul J; Liu, Lei; Ghebremariam, Yohannes T; Ivey, Kathryn N; Cooke, John P; Srivastava, Deepak | Limited gene expression variation in human embryonic stem cell and induced pluripotent stem cell-derived endothelial cells | view |
| Blazeski, Adriana; Zhu, Renjun; Hunter, David W; Weinberg, Seth H; Zambidis, Elias T; Tung, Leslie | Cardiomyocytes derived from human induced pluripotent stem cells as models for normal and diseased cardiac electrophysiology and contractility | view |
| Blazeski, Adriana; Zhu, Renjun; Hunter, David W; Weinberg, Seth H; Boheler, Kenneth R; Zambidis, Elias T; Tung, Leslie | Electrophysiological and contractile function of cardiomyocytes derived from human embryonic stem cells | view |
| Panicker, Leelamma M; Miller, Diana; Park, Tea Soon; Patel, Brijesh; Azevedo, Judi L; Awad, Ola; Masood, M Athar; Veenstra, Timothy D; Goldin, Ehud; Stubblefield, Barbara K; Tayebi, Nahid; Polumuri, Swamy K; Vogel, Stefanie N; Sidransky, Ellen; Zambidis, Elias T; Feldman, Ricardo A | Induced pluripotent stem cell model recapitulates pathologic hallmarks of Gaucher disease | view |
| Thompson, Susan A; Burridge, Paul W; Lipke, Elizabeth A; Shamblott, Michael; Zambidis, Elias T; Tung, Leslie | Engraftment of human embryonic stem cell derived cardiomyocytes improves conduction in an arrhythmogenic in vitro model | view |
| Easwaran, Hariharan; Johnstone, Sarah E; Van Neste, Leander; Ohm, Joyce; Mosbruger, Tim; Wang, Qiuju; Aryee, Martin J; Joyce, Patrick; Ahuja, Nita; Weisenberger, Dan; Collisson, Eric; Zhu, Jingchun; Yegnasubramanian, Srinivasan; Matsui, William; Baylin, Stephen B | A DNA hypermethylation module for the stem/progenitor cell signature of cancer | view |
| Guo, Hong; Ma, Ou; Speck, Nancy A; Friedman, Alan D | Runx1 deletion or dominant inhibition reduces Cebpa transcription via conserved promoter and distal enhancer sites to favor monopoiesis over granulopoiesis | view |
| Cheng, Linzhao; Hansen, Nancy F; Zhao, Ling; Du, Yutao; Zou, Chunlin; Donovan, Frank X; Chou, Bin-Kuan; Zhou, Guangyu; Li, Shijie; Dowey, Sarah N; Ye, Zhaohui; NISC Comparative Sequencing Program; Chandrasekharappa, Settara C; Yang, Huanming; Mullikin, James C; Liu, P Paul | Low incidence of DNA sequence variation in human induced pluripotent stem cells generated by nonintegrating plasmid expression | view |
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