HS01 - Poncz Hub Site
Dr. Mortimer Poncz leads Hub Site 01 located at the Children's Hospital of Philadelphia (CHOP). His research efforts focus on the megakaryocyte-platelet-thrombus axis. The process by which hematopoietic stem cells differentiate into megakaryocytes, which then release platelets and the function of platelets in thrombosis and inflammation are the central foci of my laboratory. Many of the studies focus on the biology and pathobiology of the platelet-specific proteins, chemokines Platelet Factor 4 (PF4)/Platelet Basic Protein (PBP) and the integrin alphaIIb/beta3 receptor.
Protocols and Reagents that are associated with this hub site can be accessed by logging into Synapse and searching the database from the appropriate list of protocols or reagents. Click here for instructions to access Synapse.
| User Name | Full Name | Institutional Affilication | |
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mponcz | Mortimer Poncz, M.D. | Children's Hospital of Philadelphia |
| User Name | Full Name | Institutional Affilication | |
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mweiss | Mitchell Weiss, M.D., Ph.D. | Children's Hospital of Philadelphia |
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pgadue | Paul Gadue, Ph.D. | Children's Hospital of Philadelphia |
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ssullivan | Spencer Sullivan, M.D. | CHOP |
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dfrench | Deborah French, Ph.D. | Children's Hospital of Philadelphia |
| User Name | Full Name | Institutional Affilication | |
|---|---|---|---|
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lalit | Pratik Lalit | University of Wisconsin |
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karenvo | Karen Vo | University of Pennsylvania |
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simxiuli | Xiuli Sim | The Children's Hospital of Philadelphia |
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rlyde | Randolph B. Lyde | University of Pennsylvania |
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oshemer | Orna Steinberg Shemer, M.D., M.Sc. | The Children's Hospital of Philadelphia |
Pages
| Author(s) | Title | Link |
|---|---|---|
| Ono, Yukako; Wang, Yuhuan; Suzuki, Hidenori; Okamoto, Shinichiro; Ikeda, Yasuo; Murata, Mitsuru; Poncz, Mortimer; Matsubara, Yumiko | Induction of functional platelets from mouse and human fibroblasts by p45NF-E2/Maf | view |
| Meng, Ronghua; Wang, Yuhuan; Yao, Yu; Zhang, Zhe; Harper, Dawn C; Heijnen, Harry F G; Sitaram, Anand; Li, Wei; Raposo, Graca; Weiss, Mitchell J; Poncz, Mortimer; Marks, Michael S | SLC35D3 delivery from megakaryocyte early endosomes is required for platelet dense granule biogenesis and is differentially defective in Hermansky-Pudlak syndrome models. | view |
| Chou, Stella T; Byrska- Bishop, Marta; Tober, Joanna M; Yao, Yu; Vandorn, Daniel; Opalinska, Joanna B; Mills, Jason A; Choi, John Kim; Speck, Nancy A; Gadue, Paul; Hardison, Ross C; Nemiroff, Richard L; French, Deborah L; Weiss, Mitchell J | Trisomy 21-associated defects in human primitive hematopoiesis revealed through induced pluripotent stem cells | view |
| Fuentes, Rudy; Wang, Yuhuan; Hirsch, Jessica; Wang, Cheng; Rauova, Lubica; Worthen, G Scott; Kowalska, M Anna; Poncz, Mortimer | Infusion of mature megakaryocytes into mice yields functional platelets | view |
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