Funded PCBC Projects: Pilot and Ancillary/Collaborative Studies
The mission of the NHLBI Progenitor Cell Biology Consortium is to develop improved understanding of the biology of stem and progenitor cells, and to harness this knowledge for the diagnosis and treatment of heart, lung, and blood diseases. The Consortium comprises nine multidisciplinary virtual research hubs supported by an Administrative Coordinating Center. Research directions for the Consortium include: 1) identifying and characterizing progenitor cell lines; 2) directing the differentiation of stem and progenitor cells to desired fates; and 3) developing new strategies to address the unique challenges presented by the transplantation of these cells.
NHLBI has awarded funds for pilot studies to foster innovative, high-risk approaches with a potential for unusually high impact to advance the field significantly.
In addition, funds are also allocated for ancillary and collaborative projects to foster interactions between research hubs and to bring in expertise from outside the PCBC to move PCBC projects in new directions.
Below is a list of currently funded PCBC Projects:
2014 Awarded Ancillary/Collaborative Studies
Project Title: Cohesin’s Role in Regulating Pluripotency, Hematopoietic Progenitor Cells (HPCs) and Differentiated Megakaryocytes
Anc/Col Study Principal Investigators: Jason Mills, Ph.D., and Katsuhiko Shirahige, Ph.D.
Hub Site Principal Investigator: Mortimer Poncz, M.D.
Awarded Organization: The Children’s Hospital of Philadelphia and The University of Tokyo
Abstract: /content/cohesins-role-regulating-pluripotency-hpcs-and-differentiated-megakaryocytes
Project Title: Naïve Cas9-hESC Line for CRISPR Functional Screens
Anc/Col Study Principal Investigators: Patrick Paddison, Ph.D., and Hannele Ruohola- Baker, Ph.D.
Hub Site Principal Investigator: Beverly Torok-Storb, Ph.D.
Awarded Organization: University of Washington and Fred Hutchinson Cancer Research Center
Abstract: /content/na%C3%AFve-cas9-hesc-line-crispr-functional-screens
Project Title: Embryonic Pathways to HSC Development
Anc/Col Study Principal Investigators: Irwin Bernstein, M.D., and Mervin Yoder, M.D.
Hub Site Principal Investigator: Irwin Bernstein, M.D.
Awarded Organization: Fred Hutchinson Cancer Research Center and Indiana University
Abstract: /content/embryonic-pathways-hsc-development
Project Title: Derivation of Transplantable Human Hematopoietic Stem Cells Using Defined Factors
Anc/Col Study Principal Investigators: David Scadden, M.D., and Derrick Rossi, Ph.D.
Hub Site Principal Investigator: David Scadden, M.D.
Awarded Organization: Massachusetts General Hospital and Children’s Hospital Corporation
Abstract: /content/derivation-transplantable-human-hematopoietic-stem-cells-using-defined-factors
Project Title: Dissecting the Role of RBM20 in Dilated Cardiomyopathy Using Isogenic iPSCs
Anc/Col Study Principal Investigators: Bruce Conklin, M.D., and Nathan Salomonis, Ph.D.
Hub Site Principal Investigator: Deepak Srivastava, M.D.
Awarded Organization: J. David Gladstone Institutes & Cincinnati Children’s Hospital Medical Center
Abstract: /content/dissecting-role-rbm20-dilated-cardiomyopathy-using-isogenic-ipscs
2014 Awarded Pilot Studies
Project Title: Defining Stem and Stromal Cell Couples in Hematopoiesis
Pilot Study Principal Investigator: David T. Scadden, M.D.
Hub Site Principal Investigator: David T. Scadden, M.D.
Awarded Organization: Massachusetts General Hospital
Abstract: /content/defining-stem-and-stromal-cell-couples-hematopoiesis
Project Title: Leveraging Innate Immunity and Death Receptor Pathways for Nuclear Reprogramming
Pilot Study Principal Investigator: Nazish Sayed, M.D., Ph.D.
Hub Site Principal Investigator: John Cooke, M.D., Ph.D.
Awarded Organization: The Methodist Hospital Research Institute
Abstract: /content/leveraging-innate-immunity-and-death-receptor-pathways-nuclear-reprogramming
2013 Awarded Ancillary/Collaborative Studies
Project Title: Induction of Stem Cell Expansion by the Vascular Niche
Ancillary Study Principal Investigator: Shahin Rafii, M.D.
Hub Site Principal Investigator: Irwin Bernstein, M.D.
Awarded Organization: Fred Hutchinson Cancer Research
Abstract: /content/induction-stem-cell-expansion-vascular-niche
Project Title: Generation & Characterization of a Lung Stem Cell “Tool Kit” to Generate Functional Lung Epithelial Lineages
Ancillary Study Principal Investigators: Paul Gadue Ph.D. and Darrell Kotten, M.D.
Hub Site Principal Investigator: Edward Morrisey, Ph.D..
Awarded Organization: Trustees of the University of Pennsylvania
2013 Awarded Pilot Studies
Project Title: Non-coding RNA Expression for Evaluating Reprogramming Quality of Human iPSC
Pilot Study Principal Investigator: Elias Zambidis, M.D., Ph.D.
Hub Site Principal Investigator: Alan Friedman, M.D.
Awarded Organizations: Johns Hopkins University School of Medicine
Abstract: /content/non-coding-rna-expression-evaluating-reprogramming-quality-human-ipscabstract
Project Title: NHLBI Progenitor Cell Biology Consortium -- Pilot Studies and number (RFP PCBC2012Pilot01)/ Transflammation: It's Role in Direct Reprogramming
Pilot Study Principal Investigator: John Cooke, M.D., Ph.D.
Hub Site Principal Investigator: John Cooke, M.D., Ph.D.
Awarded Organization: Stanford University
Abstract: /content/transflammation-its-role-direct-reprogrammingabstract
2012 Awarded Ancillary/Collaborative Studies
Project Title: A Mechanism-guided Chemical Biology Approach to iPSC-derived Cardiomyocyte Death
Ancillary Site Principal Investigator: Richard N. Kitsis, M.D.
Hub Site Principal Investigator: Robert C. Robbins, M.D.
Awarded Organization: Albert Einstein College of Medicine
Abstract: /content/mechanism-guided-chemical-biology-approach-ipsc-derived-cardiomyocyte-death
Project Title: Increasing Stem Cell Numbers While Retaining Stem Cell Function
Ancillary Site Principal Investigator: George E. Georges, M.D.
Hub Site Principal Investigator: Beverly Torok-Storb, Ph.D.
Awarded Organization: Fred Hutchinson Cancer Research Center
Abstract: /content/increasing-stem-cell-numbers-while-retaining-stem-cell-function
Project Title: Safe, rapid telomere extension in diverse progenitor cell types
Collaborative Site Principal Investigator: Helen Blau, Ph.D.
Hub Site Principal Investigator: John Cooke, M.D., Ph.D.
Awarded Organization: Stanford University
Abstract: /content/safe-rapid-telomere-extension-diverse-progenitor-cell-types
Project Title: NHLBI Progenitor Cell Biology Consortium Ancillary Project Collaborative Site Principal Investigators: Charles Murry, M.D., Gordon Keller, Ph.D., Wolfram-Hubertus Zimmermann, M.D.
Hub Site Principal Investigator: Ed Morrisey, Ph.D.
Awarded Organization: University of Washington
Abstract: /content/nhlbi-progenitor-cell-biology-consortium-ancillary-project-collaborative
2012 Awarded Pilot Studies
Project Title: Investigating Histone Demethylase Function During Hematopoietic Lineage Formation
Pilot Study Principal Investigator: Patrick Paddison, Ph.D.
Hub Site 05 Principal Investigator: Beverly Torok-Storb, Ph.D.
Applicant Organization: Fred Hutchinson Cancer Research Center
Abstract: /content/investigating-histone-demethylase-function-during-hematopoietic-lineage-formation
Project Title: HistoPaints: Antibody Surrogates Applicable to Solid Tissues
Pilot Study Principal Investigator: Pehr Harbury, Ph.D.
Hub Site 07 Principal Investigator: Mark Krasnow, M.D., Ph.D.
Applicant Organization: Stanford University
Abstract: /content/histopaints-antibody-surrogates-applicable-solid-tissues
Project Title: Hematopoietic Stem Cells from Embryo to ES Cells
Pilot Study Principal Investigator: Nancy Speck, Ph.D.
Hub Site 14 Principal Investigator: Edward Morrisey, Ph.D.
Applicant Organization: University of Pennsylvania
Abstract: /content/hematopoietic-stem-cells-embryo-es-cells
Project Title: Generation of Cardiomyocytes from Muscle Satellite Cells of the Head
Pilot Study Principal Investigator: Jonathan Slack, Ph.D.
Hub Site 16 Principal Investigator: Daniel Garry, M.D., Ph.D.
Applicant Organization: University of Minnesota
Abstract: /content/generation-cardiomyocytes-muscle-satellite-cells-head
2011 Awarded Ancillary/Collaborative Studies
Project Title: Selection and Electromechanical Maturation of Ventricular Mycocytes from hiPSs
Ancillary Study/Hub Site 14 Principal Investigator: Edward Morrisey, Ph.D.
Ancillary Center Principal Investigator: Michael Laflamme, Ph.D., University of Washington
Applicant Organization: University of Pennsylvania
Abstract: /content/selection-and-electromechanical-maturation-ventricular-mycocytes-hipss
Project Title: Ancillary Project – Genomewide Methylation Analyses of Human Hematopoietic Progenitors
Ancillary Study/Hub Site 07 Principal Investigator: Irving Weissman, M.D., Stanford University
Ancillary Center Principal Investigator: Andrew Feinberg, M.D., M.P.H., The Johns Hopkins University
Applicant Organization: The Johns Hopkins University
Abstract: /content/genomewide-methylation-analyses-human-hematopoietic-progenitors
Project Title: Erythoid Precursors from ES and iPS Cells
Ancillary Study/Hub Site 01 Principal Investigator: Mitchell Weiss, M.D., Ph.D.
Ancillary Center Principal Investigator: James Palis, M.D., University of Rochester
Applicant Organization: Children’s Hospital of Philadelphia
Abstract: /content/erythoid-precursors-es-and-ips-cells
Project Title: Ancillary Studies of Lung Stem/Progenitor Cell Epithelial-Mesenchymal Signaling
Ancillary Study/Hub Site 13 Principal Investigator: David Scadden, M.D., Massachusetts General Hospital
Ancillary Center Principal Investigator: Scott H. Randell, Ph.D., University of North Carolina
Applicant Organization: Massachusetts General Hospital
Abstract: /content/ancillary-studies-lung-stemprogenitor-cell-epithelial-mesenchymal-signaling
2011 Awarded Pilot Studies
Project Title: Extracellular Matrix Microenvironment for Endothelial and Cardiomyocyte Differentiation
Pilot Study Principal Investigator: Stephane Y. Corbel, Ph.D.
Hub Site 10 Principal Investigator: John Cooke, M.D., Ph.D.
Applicant Organization: Stanford University
Abstract: /content/extracellular-matrix-microenvironment-endothelial-and-cardiomyocyte-differentiation
Project Title: Determination of the Role of Endothelial Cells and Mesenchymal Cells in Regulating Lung
Pilot Study Principal Investigator: Carla Kim, Ph.D./Amy Wagers, Ph.D.
Hub Site 13 Principal Investigator: David Scadden, M.D.
Applicant Organization: The General Hospital Corporation
Abstract: /content/determination-role-endothelial-cells-and-mesenchymal-cells-regulating-lung
Project Title: MicroRNA and Small Molecule Reprogramming to Pluripotency
Pilot Study Principal Investigator: Edward Morrisey, Ph.D.
Hub Site 14 Principal Investigator: Edward Morrisey, Ph.D.
Applicant Organization: University of Pennsylvania
Abstract: /content/microrna-and-small-molecule-reprogramming-pluripotency
Copyright ©2013 NHLBI Progenitor Cell Biology Consortium.
