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Funded PCBC Projects: Pilot and Ancillary/Collaborative Studies

The mission of the NHLBI Progenitor Cell Biology Consortium is to develop improved understanding of the biology of stem and progenitor cells, and to harness this knowledge for the diagnosis and treatment of heart, lung, and blood diseases. The Consortium comprises nine multidisciplinary virtual research hubs supported by an Administrative Coordinating Center. Research directions for the Consortium include: 1) identifying and characterizing progenitor cell lines; 2) directing the differentiation of stem and progenitor cells to desired fates; and 3) developing new strategies to address the unique challenges presented by the transplantation of these cells.

NHLBI has awarded funds for pilot studies to foster innovative, high-risk approaches with a potential for unusually high impact to advance the field significantly.

In addition, funds are also allocated for ancillary and collaborative projects to foster interactions between research hubs and to bring in expertise from outside the PCBC to move PCBC projects in new directions.

Below is a list of currently funded PCBC Projects:

2014 Awarded Ancillary/Collaborative Studies

Project Title: Cohesin’s Role in Regulating Pluripotency, Hematopoietic Progenitor Cells (HPCs) and Differentiated Megakaryocytes

Anc/Col Study Principal Investigators: Jason Mills, Ph.D., and Katsuhiko Shirahige, Ph.D.

Hub Site Principal Investigator: Mortimer Poncz, M.D.

Awarded Organization: The Children’s Hospital of Philadelphia and The University of Tokyo

Abstract: /content/cohesins-role-regulating-pluripotency-hpcs-and-differentiated-megakaryocytes

 

Project Title: Naïve Cas9-hESC Line for CRISPR Functional Screens

Anc/Col Study Principal Investigators: Patrick Paddison, Ph.D., and Hannele Ruohola- Baker, Ph.D.

Hub Site Principal Investigator: Beverly Torok-Storb, Ph.D.

Awarded Organization: University of Washington and Fred Hutchinson Cancer Research Center

Abstract: /content/na%C3%AFve-cas9-hesc-line-crispr-functional-screens

 

 

Project Title: Embryonic Pathways to HSC Development

Anc/Col Study Principal Investigators: Irwin Bernstein, M.D., and Mervin Yoder, M.D.

Hub Site Principal Investigator: Irwin Bernstein, M.D.

Awarded Organization: Fred Hutchinson Cancer Research Center and Indiana University

Abstract:  /content/embryonic-pathways-hsc-development

 

 

Project Title: Derivation of Transplantable Human Hematopoietic Stem Cells Using Defined Factors

Anc/Col Study Principal Investigators: David Scadden, M.D., and Derrick Rossi, Ph.D.

Hub Site Principal Investigator: David Scadden, M.D.

Awarded Organization: Massachusetts General Hospital and Children’s Hospital Corporation

Abstract: /content/derivation-transplantable-human-hematopoietic-stem-cells-using-defined-factors

 

Project Title: Dissecting the Role of RBM20 in Dilated Cardiomyopathy Using Isogenic iPSCs

Anc/Col Study Principal Investigators: Bruce Conklin, M.D., and Nathan Salomonis, Ph.D.

Hub Site Principal Investigator: Deepak Srivastava, M.D.

Awarded Organization: J. David Gladstone Institutes & Cincinnati Children’s Hospital Medical Center

Abstract: /content/dissecting-role-rbm20-dilated-cardiomyopathy-using-isogenic-ipscs

 


2014 Awarded Pilot Studies

Project Title: Defining Stem and Stromal Cell Couples in Hematopoiesis

Pilot Study Principal Investigator: David T. Scadden, M.D.

Hub Site Principal Investigator: David T. Scadden, M.D.

Awarded Organization: Massachusetts General Hospital

Abstract: /content/defining-stem-and-stromal-cell-couples-hematopoiesis

 

Project Title: Leveraging Innate Immunity and Death Receptor Pathways for Nuclear Reprogramming

Pilot Study Principal Investigator: Nazish Sayed, M.D., Ph.D.

Hub Site Principal Investigator: John Cooke, M.D., Ph.D.

Awarded Organization: The Methodist Hospital Research Institute

Abstract: /content/leveraging-innate-immunity-and-death-receptor-pathways-nuclear-reprogramming

 


 

2013 Awarded Ancillary/Collaborative Studies

 

Project Title: Induction of Stem Cell Expansion by the Vascular Niche

Ancillary Study Principal Investigator: Shahin Rafii, M.D.

Hub Site Principal Investigator: Irwin Bernstein, M.D.

Awarded Organization: Fred Hutchinson Cancer Research

Abstract: /content/induction-stem-cell-expansion-vascular-niche

 

Project Title: Generation & Characterization of a Lung Stem Cell “Tool Kit” to Generate Functional Lung Epithelial Lineages

Ancillary Study Principal Investigators: Paul Gadue Ph.D. and Darrell Kotten, M.D.

Hub Site Principal Investigator: Edward Morrisey, Ph.D..

Awarded Organization: Trustees of the University of Pennsylvania

Abstract: /content/generation-characterization-lung-stem-cell-%E2%80%9Ctool-kit%E2%80%9D-generate-functional-lung-epithelial-li

 


 

2013 Awarded Pilot Studies

Project Title: Non-coding RNA Expression for Evaluating Reprogramming Quality of Human iPSC

Pilot Study Principal Investigator: Elias Zambidis, M.D., Ph.D.

Hub Site Principal Investigator: Alan Friedman, M.D.

Awarded Organizations: Johns Hopkins University School of Medicine

Abstract: /content/non-coding-rna-expression-evaluating-reprogramming-quality-human-ipscabstract

 

Project Title: NHLBI Progenitor Cell Biology Consortium -- Pilot Studies and number (RFP PCBC2012Pilot01)/ Transflammation: It's Role in Direct Reprogramming

Pilot Study Principal Investigator: John Cooke, M.D., Ph.D.

Hub Site Principal Investigator: John Cooke, M.D., Ph.D.

Awarded Organization: Stanford University

Abstract: /content/transflammation-its-role-direct-reprogrammingabstract

 


 

2012 Awarded Ancillary/Collaborative Studies

Project Title: A Mechanism-guided Chemical Biology Approach to iPSC-derived Cardiomyocyte Death

Ancillary Site Principal Investigator: Richard N. Kitsis, M.D.

Hub Site Principal Investigator: Robert C. Robbins, M.D.

Awarded Organization: Albert Einstein College of Medicine

Abstract: /content/mechanism-guided-chemical-biology-approach-ipsc-derived-cardiomyocyte-death

 

Project Title: Increasing Stem Cell Numbers While Retaining Stem Cell Function

Ancillary Site Principal Investigator: George E. Georges, M.D.

Hub Site Principal Investigator: Beverly Torok-Storb, Ph.D.

Awarded Organization: Fred Hutchinson Cancer Research Center

Abstract: /content/increasing-stem-cell-numbers-while-retaining-stem-cell-function

 

Project Title: Safe, rapid telomere extension in diverse progenitor cell types

Collaborative Site Principal Investigator: Helen Blau, Ph.D.

Hub Site Principal Investigator: John Cooke, M.D., Ph.D.

Awarded Organization: Stanford University

Abstract: /content/safe-rapid-telomere-extension-diverse-progenitor-cell-types

 

Project Title: NHLBI Progenitor Cell Biology Consortium Ancillary Project Collaborative Site Principal Investigators: Charles Murry, M.D., Gordon Keller, Ph.D., Wolfram-Hubertus Zimmermann, M.D.

Hub Site Principal Investigator: Ed Morrisey, Ph.D.

Awarded Organization: University of Washington

Abstract: /content/nhlbi-progenitor-cell-biology-consortium-ancillary-project-collaborative

 


2012 Awarded Pilot Studies

Project Title: Investigating Histone Demethylase Function During Hematopoietic Lineage Formation

Pilot Study Principal Investigator: Patrick Paddison, Ph.D.

Hub Site 05 Principal Investigator: Beverly Torok-Storb, Ph.D.

Applicant Organization: Fred Hutchinson Cancer Research Center

Abstract: /content/investigating-histone-demethylase-function-during-hematopoietic-lineage-formation

 

Project Title: HistoPaints: Antibody Surrogates Applicable to Solid Tissues

Pilot Study Principal Investigator: Pehr Harbury, Ph.D.

Hub Site 07 Principal Investigator: Mark Krasnow, M.D., Ph.D.

Applicant Organization: Stanford University

Abstract: /content/histopaints-antibody-surrogates-applicable-solid-tissues

 

Project Title: Hematopoietic Stem Cells from Embryo to ES Cells

Pilot Study Principal Investigator: Nancy Speck, Ph.D.

Hub Site 14 Principal Investigator: Edward Morrisey, Ph.D.

Applicant Organization: University of Pennsylvania

Abstract: /content/hematopoietic-stem-cells-embryo-es-cells

 

Project Title: Generation of Cardiomyocytes from Muscle Satellite Cells of the Head

Pilot Study Principal Investigator: Jonathan Slack, Ph.D.

Hub Site 16 Principal Investigator: Daniel Garry, M.D., Ph.D.

Applicant Organization: University of Minnesota

Abstract: /content/generation-cardiomyocytes-muscle-satellite-cells-head

 


2011 Awarded Ancillary/Collaborative Studies

Project Title: Selection and Electromechanical Maturation of Ventricular Mycocytes from hiPSs

Ancillary Study/Hub Site 14 Principal Investigator: Edward Morrisey, Ph.D.

Ancillary Center Principal Investigator: Michael Laflamme, Ph.D., University of Washington

Applicant Organization: University of Pennsylvania

Abstract: /content/selection-and-electromechanical-maturation-ventricular-mycocytes-hipss

 

Project Title: Ancillary Project – Genomewide Methylation Analyses of Human Hematopoietic Progenitors

Ancillary Study/Hub Site 07 Principal Investigator: Irving Weissman, M.D., Stanford University

Ancillary Center Principal Investigator: Andrew Feinberg, M.D., M.P.H., The Johns Hopkins University

Applicant Organization: The Johns Hopkins University

Abstract: /content/genomewide-methylation-analyses-human-hematopoietic-progenitors

 

Project Title: Erythoid Precursors from ES and iPS Cells

Ancillary Study/Hub Site 01 Principal Investigator: Mitchell Weiss, M.D., Ph.D.

Ancillary Center Principal Investigator: James Palis, M.D., University of Rochester

Applicant Organization: Children’s Hospital of Philadelphia

Abstract: /content/erythoid-precursors-es-and-ips-cells

 

Project Title: Ancillary Studies of Lung Stem/Progenitor Cell Epithelial-Mesenchymal Signaling

Ancillary Study/Hub Site 13 Principal Investigator: David Scadden, M.D., Massachusetts General Hospital

Ancillary Center Principal Investigator: Scott H. Randell, Ph.D., University of North Carolina

Applicant Organization: Massachusetts General Hospital

Abstract: /content/ancillary-studies-lung-stemprogenitor-cell-epithelial-mesenchymal-signaling

 


2011 Awarded Pilot Studies

Project Title: Extracellular Matrix Microenvironment for Endothelial and Cardiomyocyte Differentiation

Pilot Study Principal Investigator: Stephane Y. Corbel, Ph.D.

Hub Site 10 Principal Investigator: John Cooke, M.D., Ph.D.

Applicant Organization: Stanford University

Abstract: /content/extracellular-matrix-microenvironment-endothelial-and-cardiomyocyte-differentiation

 

Project Title: Determination of the Role of Endothelial Cells and Mesenchymal Cells in Regulating Lung

Pilot Study Principal Investigator: Carla Kim, Ph.D./Amy Wagers, Ph.D.

Hub Site 13 Principal Investigator: David Scadden, M.D.

Applicant Organization: The General Hospital Corporation

Abstract: /content/determination-role-endothelial-cells-and-mesenchymal-cells-regulating-lung

 

Project Title: MicroRNA and Small Molecule Reprogramming to Pluripotency

Pilot Study Principal Investigator: Edward Morrisey, Ph.D.

Hub Site 14 Principal Investigator: Edward Morrisey, Ph.D.

Applicant Organization: University of Pennsylvania

Abstract: /content/microrna-and-small-molecule-reprogramming-pluripotency

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