Currently Funded Jump Start Awards
Purpose of the Jump Start Award:
To provide the PCBC with a mechanism to quickly award small grants to junior faculty (less than 5 years from their appointment to Assistant Professor), research associates, fellows, postdocs, and graduate students to support a well-defined specific aim. The aim should involve at least one of the following, with priority given to proposals that incorporate two:
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The application of new technology to an existing research question
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The generation of preliminary data for a new research goal and grant application
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The facilitation of inter–hub collaboration
Below is a list of funded Jump Start Awards:
March 2016 Cycle
1. Project Title: “Dissecting the Genome-wide Epigenetic Signature of Dilated Cardiomyopathy in iPSC-CM Model”
Principal Investigator: HaoDi Wu, Ph.D.
Hub Site Principal Investigator: Joseph Wu, M.D., Ph.D.
Awarded Organization: Stanford University
JS Award #: PCBC_JS_2016/1_01
2. Project Title: “Combined Single-Cell Functional and Transcriptomic Characterization of iPSC-derived Cardiac Myocytes”
Principal Investigator: Ayhan Atmanli, Ph.D.
Hub Site Principal Investigator: Kit Parker, Ph.D.
Awarded Organization: Massachusetts General Hospital
JS Award #: PCBC_JS_2016/1_02
3. Project Title: “Identification of Transcriptional/epigenetic Facilitators and Barriers to Nuclear Reprogramming by Single Cell RNA-sequencing within and outside the 'Goldilocks’ zone'”
Principal Investigator: Palas Kumar Chanda, Ph.D.
Hub Site Principal Investigator: John Cooke, M.D., Ph.D.
Awarded Organization: The Methodist Hospital Research Institute
JS Award #: PCBC_JS_2016/1_03
4. Project Title: “Guiding Targeted Epithelial Regeneration on Acellular Lung Scaffolds with Reporter iPSC Lines"
Principal Investigator: Sarah Gilpin, Ph.D.
Hub Site Principal Investigator: David Scadden, M.D.
Awarded Organization: Massachusetts General Hospital
JS Award #: PCBC_JS_2016/1_04
December 2015 Cycle
1. Project Title: “3D Printing of Bioengineered Platforms for High-throughput Cardiotoxicity Screening”
Principal Investigator: Vahid Serpooshan, Ph.D.
Hub Site Principal Investigator: Joseph Wu, M.D., Ph.D.
Awarded Organization: Stanford University
JS Award #: PCBC_JS_2015/4_01
2. Project Title: “Modified Short Guide RNA Directed Neonatal Rat Ventricle Cardiomyocyte Genome Editing”
Principal Investigator: Zhiqiang Lin, Ph.D.
Hub Site Principal Investigator: Jay Schneider, M.D., Ph.D.
Awarded Organization: Children’s Hospital Corporation
JS Award #: PCBC_JS_2015/4_02
3. Project Title: “Genome Engineering Isogenic Human Pluripotent Stem Cells to Model Restrictive Cardiomyopathy”
Principal Investigator: Dongjian Hu, Ph.D. Candidate
Hub Site Principal Investigator: Kevin Kit Parker, Ph.D.
Awarded Organization: The General Hospital Corporation
JS Award #: PCBC_JS_2015/4_03
September 2015 Cycle
Project Title: “Single Cell Characterization of Spc+ Progenitors in the Lung”
Principal Investigator and Collaborators: John Mahoney, Ph.D., Carla Kim, Ph.D, Jason Rock, Ph.D., and Mark Krasnow, Ph.D.
Hub Site Principal Investigators: Mark Krasnow, M.D., Ph.D. and David Scadden, M.D.
Awarded Organization: Children’s Hospital Boston
JS Award #: PCBC_JS_2015/3_01
June 2015 Cycle
Project Title: “Non-Destructive Intracellular Monitoring of Cardiomyocyte Differentiation ”
Principal Investigators: Yuhong Cao, Ph.D., & Haodong Chen, Ph.D.
Hub Site Principal Investigator: Joseph Wu, M.D., Ph.D.
Awarded Organization: Stanford University
JS Award #: PCBC _JS_2015/2_01
March 2015 Cycle
1. Project Title: “Single Cell Analysis of Human Naïve Pluripotent Stem Cells and their Derivatives”
Principal Investigator: Ludovic Zimmerlin, Ph.D.
Hub Site Principal Investigator: Alan Friedman, M.D.
Awarded Organization: Johns Hopkins University, School of Medicine
JS Award #: PCBC _JS_2015/1_01
2. Project Title: “Rescue of Duchenne Muscular Dystrophy Cardiomyocyte Function by Myoediting”
Principal Investigator: Chengzu Long, Ph.D.
Hub Site Principal Investigator: Jay Schneider, M.D., Ph.D.
Awarded Organization: University of Texas Southwestern Medical Center
JS Award #: PCBC _JS_2015/1_02
3. Project Title: “Multiplex Analysis of Gene Expression in Individual Living Cells”
Principal Investigator: Ayhan Atmanli
Hub Site Principal Investigator: Kevin Parker, Ph.D.
Awarded Organization: Massachusetts General Hospital
JS Award #: PCBC _JS_2015/1_03
December 2014 Cycle
1. Project Title: “Real-time PCR to Assess Induced Pluripotent Stem Cell Pluripotency and Differentiation Potential”
Principal Investigator: Jared Churko, Ph.D..
Hub Site Principal Investigator: Joseph Wu, M.D., Ph.D.
Awarded Organization: Stanford University
JS Award #: PCBC _JS_2014/4_01
2. Project Title: “Determine the Extent to which Epigenetically-Marked and Inaccessible Chromatin can be Targeted by Directed Small-Molecule Genome Binders”
Principal Investigator: Graham Erwin, B.S.
Hub Site Principal Investigator: James Thomson, M.D.
Awarded Organization: Morgridge Institute for Research
JS Award #: PCBC _JS_2014/4_02
September 2014 Cycle
1. Project Title: “Using iPSCs to Model Disruption of Mitochondrial Fission/Fusion in Down Syndrome”
Principal Investigator: Valentina Parra, Ph.D.
Hub Site Principal Investigator: Jay Schneider, M.D., Ph.D.
Awarded Organization: UT Southwestern Medical Center
JS Award #: PCBC_JS_2014/3-01
2. Project Title: “Single-Cell Transcriptome Analysis to Evaluate the Function of Endoglin in Quiescent Hematopoietic Stem Cells”
Principal Investigator: June Baik, M.S.
Hub Site Principal Investigator: Daniel Garry, M.D., Ph.D.
Awarded Organization: Regents of the University of Minnesota
JS Award #: PCBC_JS_2014/3-02
3. Project Title: “Reconstructing Hierarchies of Mesodermal Lineages Using Single-sell RNA-seq”
Principal Investigator: Tara Rasmussen, Ph.D.
Co-Principal Investigator: Wuming Gong, Ph.D.
Hub Site Principal Investigator: Daniel Garry, M.D., Ph.D.
Awarded Organization: Regents of the University of Minnesota
JS Award #: PCBC_JS_2014/3-03
June 2014 Cycle
1. Project Title: “Characterization of a Novel Transcription Factor in Vascular Development”
Principal Investigator: Gianfranco Matrone, Ph.D.
Hub Site Principal Investigator: John Cooke, M.D., Ph.D.
Awarded Organization: The Methodist Hospital Research Institute
JS Award #: PCBC_JS_2014/2_01
2. Project Title: “Analysis of Notch Signaling in Fetal Hematopoietic Stem Cells by Single-cell RNA sequencing”
Principal Investigator: Kostandin Pajcini, Ph.D.
Hub Site Principal Investigator: Edward Morrisey, Ph.D.
Awarded Organization: Trustees of the University of Pennsylvania
JS Award #: PCBC_JS_2014/2_02
3. Project Title: “HOPX: A Novel Regulator of Endothelial Development”
Principal Investigator: Nathan Paplant, Ph.D.
Hub Site Principal Investigator: Edward Morrisey, Ph.D.
Awarded Organization: University of Washington
JS Award #: PCBC_JS_2014/2_03
March 2014 Cycle
1. Project Title: Identification of Cardiac Lineage-Defining Epigenome at Single Cell Resolution
Principal Investigator: Guang Li, Ph.D.
Hub Site Principal Investigator: Joseph Wu, M.D., Ph.D.
Awarded Organization: Board of Trustees of the Leland Stanford Jr. University
JS Award #: PCBC_JS_2014/1_01
2. Project Title: Reprogramming Fibroblasts to a Cardiac Fate Using Modified RNA
Principal Investigator: Matthew Dickson, M.D., Ph.D.
Hub Site Principal Investigator: Jay Schneider, M.D., Ph.D.
Awarded Organization: UT Southwestern Medical Center
JS Award #: PCBC_JS_2014/1_02
3. Project Title: Identifying Novel Markers and Transcriptome Differences Between Normal and Cystic Fibrosis Primary Human Adult Upper Airway Epithelial Cells through Single Cell RNA-sequencing
Principal Investigator: Dawn Bravo, Ph.D.
Hub Site Principal Investigator: Mark Krasnow, M.D., Ph.D.
Awarded Organization: Stanford University School of Medicine
JS Award #: PCBC_JS_2014/1_03
December 2013 Cycle
1. Project Title: Develop a chemical toolkit to remodel the epigenetic landscape at targeted genomic loci
Principal Investigator: Asuka Eguchi, B.S., M.S.
Hub Site Principal Investigator: James Thomson, M.D.
Awarded Organization: Morgridge Institute for Research
JS Award #: PCBC_JS_2013/3_01
2. Project Title: Single-cell droplet digital PCR to assess allele-specific knockdown of mutated mRNA in patient-specific hiPSC-cardiomyocytes carrying dilated and hypertrophic cardiomyopathy mutations
Principal Investigator: Elena Matsa, Ph.D.
Hub Site Principal Investigator: Joseph Wu, M.D., Ph.D.
Awarded Organization: Stanford University
JS Award #: PCBC_JS_2013/3_02
3. Project Title: Characterization of Cardiomyocytes derived from Human Induced Pluripotent Cells by Single-Cell RNA-sequencing
Principal Investigator: Jared Churko, Ph.D.
Hub Site Principal Investigator: Mark Krasnow, M.D., Ph.D.
Awarded Organization: Stanford University
JS Award #: PCBC_JS_2013/3_03
September 2013 Cycle
1. Project Title: Probing heterogeneity of Mespl-induced mesoderm by single-cell RNA-seq
Principal Investigator: Sunny Sun-Kin Chan, Ph.D.
Hub Site Principal Investigator: Daniel Garry, M.D., Ph.D.
Awarded Organization: University of Minnesota
JS Award #: PCBC_JS_2013/2_01
2. Project Title: Investigating Sox17 and Wnt/ β-catenin Regulation of Hemogenic Endothelium
Principal Investigators: Raedun Clarke, Ph.D., Gordon Keller, Ph.D., Aaron Robitaille, Ph.D., Randall Moon, Ph.D.
Hub Site Principal Investigators: Irwin Bernstein, M.D. and Edward Morrisey, Ph.D.
Awarded Organizations: University Health Network and University of Washington
JS Award #: PCBC_JS_2013/2_02
June 2013 Cycle
1. Project Title: Development of a Novel Genetic Tool for Calcium Imaging and Cardiomyocyte Subtype Identification
Principal Investigator: Russell Addis, Ph.D.
Hub Site Principal Investigator: Edward Morrisey, Ph.D.
Awarded Organization: Trustees of University of Pennsylvania
JS Award #: PCBC_JS_2013/1_01
2. Project Title: Hematopoietic Single Cell cDNA Library Generation with Microfluidics and RNA Temp
Principal Investigators: Daniel Kuppers, Ph.D.
Hub Site Principal Investigator: Beverly Torok-Storb, Ph.D.
Awarded Organization: Fred Hutchinson Cancer Research Center
JS Award #: PCBC_JS_2013/1_02
3. Project Title: Examination of Differentiation of Lgr6-positive Human Lung Epithelial Stem Cells
Principal Investigator: Joo-Hyeon Lee, Ph.D.
Hub Site Principal Investigator: David Scadden, M.D.
Awarded Organization: Children’s Hospital Corporation
JS Award #: PCBC_JS_2013/1_03
March 2013 Cycle
1. Project Title: Improving the Efficiency of Cas9-mediated, Scarless Genome Editing Using Modified RNAs
Principal Investigator: Gang Wang, Ph.D.
Hub Site Principal Investigator: Jay Schneider, M.D., Ph.D.
Awarded Organization: University of Texas Southwestern
JS Award #: PCBC_JS_2012/1_01
2. Project Title: Heterokaryon as a Model for Identifying Novel Determinants of Endothelial Lineage
Principal Investigator: Wing Tak Jack Wong, Ph.D.
Hub Site Principal Investigator: John Cooke, M.D., Ph.D.
Awarded Organization: Stanford University
JS Award #: PCBC_JS_2012/1_02
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