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Currently Funded Jump Start Awards

Purpose of the Jump Start Award:

To provide the PCBC with a mechanism to quickly award small grants to junior faculty (less than 5 years from their appointment to Assistant Professor), research associates, fellows, postdocs, and graduate students to support a well-defined specific aim. The aim should involve at least one of the following, with priority given to proposals that incorporate two:

  • The application of new technology to an existing research question

  • The generation of preliminary data for a new research goal and grant application

  • The facilitation of inter–hub collaboration


Below is a list of  funded Jump Start Awards:

March 2016 Cycle

1. Project Title: “Dissecting the Genome-wide Epigenetic Signature of Dilated Cardiomyopathy in iPSC-CM Model”

Principal Investigator: HaoDi Wu, Ph.D.

Hub Site Principal Investigator: Joseph Wu, M.D., Ph.D.

Awarded Organization: Stanford University

JS Award #: PCBC_JS_2016/1_01

 

2. Project Title: “Combined Single-Cell Functional and Transcriptomic Characterization of iPSC-derived Cardiac Myocytes”

Principal Investigator: Ayhan Atmanli, Ph.D.

Hub Site Principal Investigator: Kit Parker, Ph.D.

Awarded Organization: Massachusetts General Hospital

JS Award #: PCBC_JS_2016/1_02

 

3. Project Title: “Identification of Transcriptional/epigenetic Facilitators and Barriers to Nuclear Reprogramming by Single Cell RNA-sequencing within and outside the 'Goldilocks’ zone'”

Principal Investigator: Palas Kumar Chanda, Ph.D.

Hub Site Principal Investigator: John Cooke, M.D., Ph.D.

Awarded Organization: The Methodist Hospital Research Institute

JS Award #: PCBC_JS_2016/1_03

 

4. Project Title: “Guiding Targeted Epithelial Regeneration on Acellular Lung Scaffolds with Reporter iPSC Lines"

Principal Investigator: Sarah Gilpin, Ph.D.

Hub Site Principal Investigator: David Scadden, M.D.

Awarded Organization: Massachusetts General Hospital

JS Award #: PCBC_JS_2016/1_04


December 2015 Cycle

1. Project Title: “3D Printing of Bioengineered Platforms for High-throughput Cardiotoxicity Screening”

Principal Investigator: Vahid Serpooshan, Ph.D.

Hub Site Principal Investigator: Joseph Wu, M.D., Ph.D.

Awarded Organization: Stanford University

JS Award #: PCBC_JS_2015/4_01

 

2. Project Title: “Modified Short Guide RNA Directed Neonatal Rat Ventricle Cardiomyocyte Genome Editing”

Principal Investigator: Zhiqiang Lin, Ph.D.

Hub Site Principal Investigator: Jay Schneider, M.D., Ph.D.

Awarded Organization: Children’s Hospital Corporation

JS Award #: PCBC_JS_2015/4_02

 

3. Project Title: “Genome Engineering Isogenic Human Pluripotent Stem Cells to Model Restrictive Cardiomyopathy”

Principal Investigator: Dongjian Hu, Ph.D. Candidate

Hub Site Principal Investigator: Kevin Kit Parker, Ph.D.

Awarded Organization: The General Hospital Corporation

JS Award #: PCBC_JS_2015/4_03


September 2015 Cycle

Project Title: “Single Cell Characterization of Spc+ Progenitors in the Lung”

Principal Investigator and Collaborators: John Mahoney, Ph.D., Carla Kim, Ph.D, Jason Rock, Ph.D., and Mark Krasnow, Ph.D.

Hub Site Principal Investigators: Mark Krasnow, M.D., Ph.D. and David Scadden, M.D.

Awarded Organization: Children’s Hospital Boston

JS Award #: PCBC_JS_2015/3_01


June 2015 Cycle

Project Title: “Non-Destructive Intracellular Monitoring of Cardiomyocyte Differentiation ”

Principal Investigators: Yuhong Cao, Ph.D., & Haodong Chen, Ph.D.

Hub Site Principal Investigator: Joseph Wu, M.D., Ph.D.

Awarded Organization: Stanford University  

JS Award #: PCBC _JS_2015/2_01


March 2015 Cycle

1. Project Title: “Single Cell Analysis of Human Naïve Pluripotent Stem Cells and their  Derivatives”

    Principal Investigator: Ludovic Zimmerlin, Ph.D.

    Hub Site Principal Investigator: Alan Friedman, M.D.

    Awarded Organization: Johns Hopkins University, School of Medicine

    JS Award #: PCBC _JS_2015/1_01

 

 2.  Project Title: “Rescue of Duchenne Muscular Dystrophy Cardiomyocyte Function by Myoediting”

     Principal Investigator: Chengzu Long, Ph.D.

     Hub Site Principal Investigator: Jay Schneider, M.D., Ph.D.

     Awarded Organization: University of Texas Southwestern Medical Center

     JS Award #: PCBC _JS_2015/1_02

 

3.  Project Title: “Multiplex Analysis of Gene Expression in Individual Living Cells”

     Principal Investigator: Ayhan Atmanli

     Hub Site Principal Investigator: Kevin Parker, Ph.D.

     Awarded Organization: Massachusetts General Hospital

     JS Award #: PCBC _JS_2015/1_03


December 2014 Cycle

1. Project Title: “Real-time PCR to Assess Induced Pluripotent Stem Cell Pluripotency and Differentiation Potential”

    Principal Investigator: Jared Churko, Ph.D..

    Hub Site Principal Investigator: Joseph Wu, M.D., Ph.D.

    Awarded Organization: Stanford University

    JS Award #: PCBC _JS_2014/4_01

 

2.  Project Title: “Determine the Extent to which Epigenetically-Marked and Inaccessible Chromatin can be Targeted by Directed Small-Molecule Genome Binders”

     Principal Investigator: Graham Erwin, B.S.

     Hub Site Principal Investigator: James Thomson, M.D.

     Awarded Organization: Morgridge Institute for Research

     JS Award #: PCBC _JS_2014/4_02


September 2014 Cycle

1. Project Title: “Using iPSCs to Model Disruption of Mitochondrial Fission/Fusion in Down Syndrome”

    Principal Investigator: Valentina Parra, Ph.D.

    Hub Site Principal Investigator: Jay Schneider, M.D., Ph.D.

    Awarded Organization: UT Southwestern Medical Center

    JS Award #: PCBC_JS_2014/3-01

 

2.  Project Title: “Single-Cell Transcriptome Analysis to Evaluate the Function of Endoglin in Quiescent Hematopoietic Stem Cells”

     Principal Investigator: June Baik, M.S.

     Hub Site Principal Investigator: Daniel Garry, M.D., Ph.D.

     Awarded Organization: Regents of the University of Minnesota

     JS Award #: PCBC_JS_2014/3-02

 

3. Project Title: “Reconstructing Hierarchies of Mesodermal Lineages Using Single-sell RNA-seq”

    Principal Investigator: Tara Rasmussen, Ph.D.

    Co-Principal Investigator: Wuming Gong, Ph.D.

    Hub Site Principal Investigator: Daniel Garry, M.D., Ph.D.

    Awarded Organization: Regents of the University of Minnesota

    JS Award #: PCBC_JS_2014/3-03


June 2014 Cycle

1. Project Title: “Characterization of a Novel Transcription Factor in Vascular Development”

    Principal Investigator: Gianfranco Matrone, Ph.D.

    Hub Site Principal Investigator: John Cooke, M.D., Ph.D.

    Awarded Organization: The Methodist Hospital Research Institute

   JS Award #: PCBC_JS_2014/2_01

2. Project Title: “Analysis of Notch Signaling in Fetal Hematopoietic Stem Cells by Single-cell RNA sequencing”

    Principal Investigator: Kostandin Pajcini, Ph.D.

    Hub Site Principal Investigator: Edward Morrisey, Ph.D.

    Awarded Organization: Trustees of the University of Pennsylvania

    JS Award #: PCBC_JS_2014/2_02

3. Project Title: “HOPX: A Novel Regulator of Endothelial Development”

     Principal Investigator: Nathan Paplant, Ph.D.

     Hub Site Principal Investigator: Edward Morrisey, Ph.D.

     Awarded Organization: University of Washington

     JS Award #: PCBC_JS_2014/2_03


March 2014 Cycle

1. Project Title: Identification of Cardiac Lineage-Defining Epigenome at Single Cell Resolution

    Principal Investigator: Guang Li, Ph.D.

    Hub Site Principal Investigator: Joseph Wu, M.D., Ph.D.

    Awarded Organization: Board of Trustees of the Leland Stanford Jr. University

     JS Award #: PCBC_JS_2014/1_01

 

2. Project Title: Reprogramming Fibroblasts to a Cardiac Fate Using Modified RNA

    Principal Investigator: Matthew Dickson, M.D., Ph.D.

    Hub Site Principal Investigator: Jay Schneider, M.D., Ph.D.

    Awarded Organization: UT Southwestern Medical Center

   JS Award #: PCBC_JS_2014/1_02

 

3. Project Title: Identifying Novel Markers and Transcriptome Differences Between Normal and Cystic Fibrosis  Primary Human Adult Upper Airway Epithelial Cells through Single Cell RNA-sequencing

   Principal Investigator: Dawn Bravo, Ph.D.

   Hub Site Principal Investigator: Mark Krasnow, M.D., Ph.D.

   Awarded Organization: Stanford University School of Medicine

   JS Award #: PCBC_JS_2014/1_03


December 2013 Cycle

1. Project Title: Develop a chemical toolkit to remodel the epigenetic landscape at targeted genomic loci

     Principal Investigator: Asuka Eguchi, B.S., M.S.

     Hub Site Principal Investigator: James Thomson, M.D.

     Awarded Organization: Morgridge Institute for Research

     JS Award #: PCBC_JS_2013/3_01

 

2. Project Title: Single-cell droplet digital PCR to assess allele-specific knockdown of mutated mRNA in patient-specific hiPSC-cardiomyocytes carrying dilated and hypertrophic cardiomyopathy mutations

    Principal Investigator: Elena Matsa, Ph.D.

    Hub Site Principal Investigator: Joseph Wu, M.D., Ph.D.

    Awarded Organization: Stanford University

    JS Award #: PCBC_JS_2013/3_02

 

3. Project Title: Characterization of Cardiomyocytes derived from Human Induced Pluripotent Cells by Single-Cell RNA-sequencing

    Principal Investigator: Jared Churko, Ph.D.

    Hub Site Principal Investigator: Mark Krasnow, M.D., Ph.D.

    Awarded Organization: Stanford University

    JS Award #: PCBC_JS_2013/3_03


September 2013 Cycle

1. Project Title: Probing heterogeneity of Mespl-induced mesoderm by single-cell RNA-seq

    Principal Investigator: Sunny Sun-Kin Chan, Ph.D.

    Hub Site Principal Investigator: Daniel Garry, M.D., Ph.D.

    Awarded Organization: University of Minnesota

    JS Award #: PCBC_JS_2013/2_01

 

2. Project Title: Investigating Sox17 and Wnt/ β-catenin Regulation of Hemogenic Endothelium

   Principal Investigators: Raedun Clarke, Ph.D., Gordon Keller, Ph.D., Aaron Robitaille, Ph.D., Randall Moon, Ph.D.

   Hub Site Principal Investigators: Irwin Bernstein, M.D. and Edward Morrisey, Ph.D.

   Awarded Organizations: University Health Network and University of Washington

   JS Award #: PCBC_JS_2013/2_02


June 2013 Cycle

1. Project Title: Development of a Novel Genetic Tool for Calcium Imaging and Cardiomyocyte Subtype Identification

    Principal Investigator: Russell Addis, Ph.D.

    Hub Site Principal Investigator: Edward Morrisey, Ph.D.

    Awarded Organization: Trustees of University of Pennsylvania

    JS Award #: PCBC_JS_2013/1_01

 

2. Project Title: Hematopoietic Single Cell cDNA Library Generation with Microfluidics and RNA Temp

   Principal Investigators: Daniel Kuppers, Ph.D.

   Hub Site Principal Investigator: Beverly Torok-Storb, Ph.D.

   Awarded Organization: Fred Hutchinson Cancer Research Center

   JS Award #: PCBC_JS_2013/1_02

 

3. Project Title: Examination of Differentiation of Lgr6-positive Human Lung Epithelial Stem Cells

    Principal Investigator: Joo-Hyeon Lee, Ph.D.

    Hub Site Principal Investigator: David Scadden, M.D.

   Awarded Organization: Children’s Hospital Corporation

   JS Award #: PCBC_JS_2013/1_03


March 2013 Cycle

1. Project Title: Improving the Efficiency of Cas9-mediated, Scarless Genome Editing Using Modified RNAs

    Principal Investigator: Gang Wang, Ph.D.

    Hub Site Principal Investigator: Jay Schneider, M.D., Ph.D.

    Awarded Organization: University of Texas Southwestern

    JS Award #: PCBC_JS_2012/1_01

 

2. Project Title: Heterokaryon as  a Model for Identifying Novel Determinants of Endothelial Lineage

    Principal Investigator: Wing Tak Jack Wong, Ph.D.

    Hub Site Principal Investigator: John Cooke, M.D., Ph.D.

    Awarded Organization: Stanford University

    JS Award #: PCBC_JS_2012/1_02

 

Click on the link below for more information on Jump Start Award:

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