“Molecular and Functional Resemblance of Differentiated Cells Derived from Isogenic Human iPSCs and SCNT-derived ESCs”

Joseph Wu, Ming-Tao Zhao, Michael Snyder, Shoukhrat Mitalipov, and colleagues reported that differentiated cells derived from human iPSCs are comparable to nuclear transfer-derived ESC counterparts with regard to transcriptional, epigenetic, physiological, and pharmacological features, given that they are genetically identical. They conclude that human iPSCs are capable of replacing SCNT for generating differentiated cells for drug testing and disease modeling. [07Dec2017 PNAS]

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