Join the #RegenMedForum on 6/26/17 to discuss the challenges and opportunities for regenerative medicine in development of new therapies at the National Academy of Sciences Building in Washington, DC.
Drs. Akhilesh Kumar, James Thomson, Igor Slukvin, and colleagues find that mesodermal pericytes and smooth muscle cells in human pluripotent stem cell cultures originate from a common endothelial and mesenchymal cell precursor, the mesenchymoangioblast. They show how different lineages of mural cells are specified from mesenchymoangioblasts and define stage- and lineage-specific markers for vasculogenic cells. [30May2017 Cell Reports]
The 2017 Cardiovascular Regenerative Medicine Symposium will take place September 27-28, 2017, at the National Institute of Health Campus in Bethesda, MD.
With the support of the NHLBI Progenitor Cell Biology Consortium (PCBC), Mark Krasnow, Tushar Desai, Pehr Harbury, and colleagues hosted a “PCBC Multiplexed in situ Hybridization Workshop” on March 22,2017, at Stanford University.
Drs. Katherine McCauley, Finn Hawkins, Darrell Kotton, and colleagues report that cyclical modulation of the canonical Wnt signaling pathway enables rapid directed differentiation of human iPSCs via an NKX2-1+ progenitor intermediate into functional proximal airway organoids. [30Mar2017 Cell Stem Cell]
Platform for Sharing and Accessing Available Protocols and Reagents
The PCBC Synapse platform, in addition to storing data is a resource for the aggregation and dissemination of protocols and reagents for the consortium.
Lehanna Sanders, a graduate student in the Hatzopoulos Hub Site 11 has initiated this PCBC Blog. Other team memebers include Nicole Stone (Srivastava Hub Site 15) and Kaytlyn Gerbin (Charles Murray's Lab - Morrisey Hub Site 14). To join the team, contact Ling Tang (ltang@epi.umaryland.edu) or Andrea Lefever (alefever@epi.umaryland.edu) for permission to post. For blog charter click here.
Drs. Timothy Kamp, Pratik Lalit, Adriana Rodriguez, and Karen Downs share a protocol that generates induced cardiac progenitor cells (iCPCs) from mouse adult fibroblasts using forced expression of Mesp1, Tbx5, Gata4, Nkx2.5 and Baf60c (MTGNB) along with Wnt and JAK/STAT signaling. [20April2017 Nature Protocols]
