Progenitor Cell Biology Consortium (PCBC) Stem Cell Collection Available Through WiCell

The Progenitor Cell Biology Consortium (PCBC) of the National Heart, Lung, and Blood Institute (NHLBI) performed comprehensive experimental and genomic analyses of iPSC and hESC lines from different laboratories derived using a variety of reprogramming methods.  Culture systems for the cell lines were harmonized. Resulting data are publicly available through Synapse.  

Publication: Spatial-Temporal Lineage Restrictions of Embryonic p63+ Progenitors Establish Distinct Stem Cell Pools in Adult Airways

Yang and colleagues (Cardoso’s lab) report on how basal cells emerge during development  and how a subset of  these progenitors mediate the pathological alveolar remodeling after influenza injury.

Spatial-Temporal Lineage Restrictions of Embryonic p63+ Progenitors Establish Distinct Stem Cell Pools in Adult Airways

Y. Yang, P. Riccio, M. Schotsaert, M. Mori, J. Lu, D-K. Lee ,A. Garcıa-Sastre, J. Xu, and W.V. Cardoso. Developmental Cell 44, 752–761, March 26, 2018

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“Molecular and Functional Resemblance of Differentiated Cells Derived from Isogenic Human iPSCs and SCNT-derived ESCs”

Joseph Wu, Ming-Tao Zhao, Michael Snyder, Shoukhrat Mitalipov, and colleagues reported that differentiated cells derived from human iPSCs are comparable to nuclear transfer-derived ESC counterparts with regard to transcriptional, epigenetic, physiological, and pharmacological features, given that they are genetically identical. They conclude that human iPSCs are capable of replacing SCNT for generating differentiated cells for drug testing and disease modeling. [07Dec2017 PNAS]

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Job Opportunity: Postdoctoral Fellow: Massachusetts General Hospital Center for Regenerative Medicine

The Sykes Lab is seeking one postdoctoral fellow to join their team.

The Sykes Lab is focused on myeloid development, and how this process goes awry in the setting of infection or malignancy to develop new treatments for patients with blood disorders, both benign (e.g., neutropenia), and malignant (e.g., leukemia).

Publication: “Synthetic Transcription Elongation Factors License Transcription Across Repressive Chromatin”

Aseem Ansari, Graham Erwin, Matthew Grieshop, and colleagues designed sequence-specific synthetic transcription elongation factors (Syn-TEFs) that convert inhibitors of transcription into gene-specific stimulators.

[30Nov2017 Science]

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Publication: “Anatomically and Functionally Distinct Lung Mesenchymal Populations Marked by Lgr5 and Lgr6”

Carla Kim, Joo-Hyeon Lee, Tuomas Tammela, and colleagues reported that heterogeneous mesenchymal cell populations in the lung play a central role in epithelial maintenance and alveolar differentiation. [07Sep2017 Cell]

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“Overcoming the Roadblocks to Cardiac Cell Therapy Using Tissue Engineering”

Report from the PCBC Cardiovascular Tissue Engineering Symposium, Birmingham, AL, March 2016

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Postdoctoral Positions – iPS cells and muscle regeneration

Two postdoctoral researcher positions are available in the laboratory of Dr. Rita Perlingeiro at the Lillehei Heart Institute, University of Minnesota, to study skeletal muscle differentiation from pluripotent stem cells (Cell Stem Cell, 10:610, 2012; Nat. Comm. 4:1549, 2013; Cell Reports, 19:2867, 2017). One project is focused on gene editing of patient-specific LGMD2I iPS cells, and the other on the development and optimization of cGMP iPS-derived myogenic progenitors for clinical trial readiness.

“PAX7 Targets, CD54, Integrin α9β1, and SDC2, Allow Isolation of Human ESC/iPSC-Derived Myogenic Progenitors” – Thomson Hub Site 02

Drs. Alessandro Magli, James Thomson, Rita Perlingeiro, and colleagues identify CD54, integrin a9b1, and SDC2 as surface markers that enable the purification of myogenic progenitors endowed with long-term regenerative potential. [27Jun2017 Cell Reports]

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Specification and Diversification of Pericytes and Smooth Muscle Cells from Mesenchymoangioblasts

Drs. Akhilesh Kumar, James Thomson, Igor Slukvin, and colleagues find that mesodermal pericytes and smooth muscle cells in human pluripotent stem cell cultures originate from a common endothelial and mesenchymal cell precursor, the mesenchymoangioblast. They show how different lineages of mural cells are specified from mesenchymoangioblasts and define stage- and lineage-specific markers for vasculogenic cells. [30May2017 Cell Reports]

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